RU2461387C2 - Method of treating dyspepsia in calves - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science. A method includes the administration of a medicinal agent. The medicinal agent is presented by 0.25% alcohol solution of Chlorophyllipt 3 ml in normal saline 57 ml which is introduced intravenously twice a day for 2-3 days in dose of 60 ml per a calve if observing simple dyspepsia and four times if observing toxic dyspepsia. It is combined with the oral introduction of 1% alcohol solution of Chlorophyllipt 10 ml at 900 ml in normal saline prescribed twice a day in dose 1000 ml in both forms of dyspepsia.

EFFECT: method provides higher therapeutic effectiveness, reduces length of treatment, has no side action on calve bodies, eliminates recurrences.

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Description

The invention relates to the field of veterinary medicine, and in particular to a method for the treatment of dyspepsia of newborn calves of a simple and toxic form, and can be used to increase the safety of young cattle, in particular calves.

Given the pathogenesis of the disease of newborn calves, agents are widely used for their treatment that contribute to the restoration of impaired metabolism and increase the general nonspecific resistance of the body. Rehydration fluids in the form of water-salt mixtures and vitamins are also used.

The use of antibiotics to suppress pathogens is widely known. But there are bacteria that are resistant to one or more antibiotics, which increases the duration of treatment for diseases caused by such pathogens. In this case, the course of therapy is carried out with the help of stronger, and therefore more toxic drugs, sometimes causing a lot of side effects (see patent 2329794, 07.27.2008).

A known method of treating sick calves with probiotics, in particular, in the complex of enterobifidin and lactobifidin at a dose of 4 ml / kg There is also a Vitom-1.1 drug for the treatment of dyspepsia, which is given to calves at a dose of 50 mg / kg twice a day until recovery (Kondrakhin I.P., Levchenko V.I., Talanov G.A. . - M .: KolosS, 2005 - p. 145-148). There is a medicine bifinorm, administered twice at a dose of 150 billion microbial cells with simple dyspepsia, and with toxic - four times (Bovkun G.F., Semenikhina V.F., Tkachev N.D. Veterinary medicine, - 1999, - 4, - p. 39-40).

However, the use of probiotics is not always accompanied by a positive effect. Often there is an unsuccessful selection of strains used to prepare probiotics. It is necessary to select field strains that are adapted to local specific conditions, which is not always acceptable in various farms. Also, the introduction of an exact dose, for example 150 billion microbial bifinorm cells, is a complex and lengthy process. Thus, this increases the duration of treatment of the disease and increases the risk of complications. In addition, the cost of the components used is high.

As a preferred analogue, we consider a method of prevention and treatment using isotonic Schappath solution. The solution consists of equal volumes of 0.9% sodium chloride solution, 1.3% sodium bicarbonate solution and 5% glucose solution. Calves are administered intravenously or subcutaneously at a dose of 300-400 ml. The disadvantage of this method is that the drug does not have an antibacterial effect, is labor intensive in the conditions of the economy and the duration of treatment (5-6 days).

EFFECT: obtaining an affordable method of treating simple and toxic forms of calf dyspepsia, preventing the development of negative processes in the body, providing a high therapeutic effect for a short period of time at minimal cost.

This is achieved by the fact that, as the main therapeutic agent, a drug from eucalyptus leaves is used - chlorophyllipt containing chlorophylls, volatile and vitamin PP. The peculiarity of its pharmacological action is selective, antibacterial activity in relation to antibiotic-resistant strains of staphylococcus; it causes detoxification, stimulates the body's defenses. The drug is non-toxic, does not have pyrogenic properties, does not contain histamine-like substances, does not affect the normal microflora of the body, unlike antibiotics.

A method of treating calves with dyspepsia is as follows.

A solution consisting of 3 ml (5%) of a 0.25% alcohol solution of chlorophyllipt was taken, 57 ml (95%) of isotonic sodium chloride solution at room temperature (21-23 ° C) was diluted and a solution ready for administration was obtained at a dose of 60 ml per animal head. With a simple form of calf dyspepsia, the finished solution in a dose of 60 ml was administered intravenously twice a day with an interval of 12 hours for 2-3 days. In a toxic form, this drug in the same volume was administered intravenously four times a day with an interval of 4 hours. In both cases, recovery occurred on the third day.

The drug was given to calves orally; twice a day in a dose of 1000 ml instead of milk. For this, 990 ml (99%) of sodium chloride was heated to a temperature of 37-38 ° C and 10 ml (1%) of a 1% alcohol solution of chlorophyllipt was added. The finished solution was administered orally twice in the morning and in the evening from a nipple drinker. In this case, recovery occurred: with a simple form of dyspepsia - on the third day, with toxic - on the fourth.

The effectiveness of treatment was evaluated by the following indicators: the duration of the disease, the period of rehabilitation, possible relapses, the outcome of the disease, the percentage of recovery and mortality.

The proposed methods, as shown by numerous studies, showed higher efficiency compared with the control. With intravenous administration with a simple and toxic form of dyspepsia, clinical recovery occurred on the third day. When giving the drug per os (inside), the recovery of calves sick with a simple form occurred on the third day, and patients with a toxic form on the fourth day, while the use of the compared method led to recovery on the fifth or sixth day and not in all animals. Control over the growth and development of ill young animals using the proposed method showed that within 3 months the incidence decreased by 2–3 times and calf gain increased compared to control groups of animals. During the application of 0.25% and 1% alcohol solutions of chlorophyllipt, a 100% therapeutic effect was obtained, reduction of treatment time (3-4 days).

Thus, the proposed method for intravenous administration of a 0.25% alcohol solution of chlorophyllipt in an isotonic sodium chloride solution at a dose of 60 ml and the oral administration of a 1% alcohol solution of chlorophyllipt diluted with an isotonic sodium chloride solution at a dose of 1000 ml has a 100% therapeutic effect, applicable in the usual and toxic form of calf dyspepsia, simple and economical.

The drug does not have side effects on the body of calves and at the same time reduces the duration of treatment for dyspepsia, consists of only two components and is available for purchase, which gives reason to recommend it for widespread use in veterinary practice.

Claims (1)

A method of treating dyspepsia in newborn calves, comprising administering a drug, characterized in that a 0.25% alcohol solution of chlorophyllipt in an amount of 3 ml in an isotonic solution of sodium chloride in an amount of 57 ml is used as a medicine, which is administered intravenously twice a day for 2-3 days at a dose of 60 ml per head of a calf with a simple form of dyspepsia and four times a day with toxic, as well as oral, 1% alcohol solution of chlorophyllipt in a volume of 10 ml per 990 ml of isotonic chlorine solution sodium ide which is set twice daily in a volume of 1000 ml in both forms of dyspepsia.