RU2341251C1 - Method of ruminant proventriculus atony treatment - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method provides oral introduction of calcium acetate in dose 0.2-0.4 g per 1 kg of body weight preliminary dissolved in water warmed up to animal body temperature.

EFFECT: allows for reduction of animal recovery terms.

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Description

The present invention relates to the field of animal husbandry, in particular to veterinary medicine, and can be used in the treatment of animals with atony of the pancreas.

Known methods of treating atony of the pancreas by prescribing: inside - enzyme preparations of maserobacillin GXx, protosubtilin GXx, aminosubtilin GXx, baker's or brewer's yeast; subcutaneously - insulin, carbocholine, pilocarpine, tincture of white hellebore; intravenously - hypertonic solutions of sodium chloride or calcium chloride (Internal non-communicable diseases of cattle. Edited by P.S. Ionov. Ed. 3rd, revised and additional - M .: Kolos, 1985. - P.11- 12; Internal non-communicable diseases of farm animals. Edited by I.G.Sharabrin. 5th edition, revised and supplemented - M .: Kolos, 1976. - P.188-189; Internal non-communicable diseases of farm animals / B .M. Anokhin, V.M.Danilevsky, L.G. Zamarin and others. Edited by V.M.Danilevsky. - M.: Agropromizdat, 1991. - P.190; Workshop on internal diseases of animals. / Under the general edition Honored Scientists of the Russian Federation, Professors A.V. Korobov and G.G. Scherbakov, 2nd ed. Rev. - St. Petersburg: Publishing House "Lan", 2004. - P.120-121; Kondrakhin I.P. Diagnostics and therapy of internal animal diseases. / I. Kondrakhin, V. Levchenko. - M.: Aquarium - Print, 2005. - P.89-91).

There is also known a method for the treatment of atony of the pre-stomachs of ruminants by oral administration of propionic acid (RU 2134578 C1, 08/20/1999) (prototype).

The disadvantage of this method is the low therapeutic efficacy in atony of the pancreas, arising against a background of impaired mineral metabolism, i.e. osteodystrophy.

The objective of the invention is to increase the effectiveness of treatment of animals with atony of the pancreas.

This is achieved by the fact that calcium acetate, which is a natural scar metabolite, is used as a therapeutic agent. It is known for its use in medicine for the treatment of kidney diseases (Hyperparathyroidism in chronic kidney disease. Treatment with active metabolites of vitamin D. / L. Lazarenko, A. Petrov, D. Sukhanov, M. Romantsov. // Doctor. - 2005. - No. 9. - S.60-65, Changes in bone tissue in patients with chronic renal failure. / O. Proshkina, Y. Sorokin. // Doctor. - 2005. - No. 11. - S.28-30).

A method is proposed for treating atony of the ruminants of the ruminants of animals by introducing calcium acetate into the body, in which animals are prescribed calcium acetate inside at doses of 0.2-0.4 g per 1 kg of live weight, previously dissolved in water heated to the body temperature of the animal.

Example. The experiment was carried out during the stall period on 24 cows in which atony of the stomach was noted. All animals were divided into 4 groups (control and three experimental) with 6 animals each.

The cows of the control group were treated with oral administration of propionic acid at a dose of 0.1 ml per 1 kg of live weight. If necessary, the drug was prescribed again in the same dose, 10-12 hours after its first use, but no more than 2 times a day. The drug was used according to this scheme until the moment of clinical recovery.

According to the results of the experiment in animals of the control group, after a single use of propionic acid, clinical recovery was noted in 16.7% of cases, after repeated use in 16.7% of cases, and after the third use in 66.6% of cases. Moreover, after the first use of propionic acid in animals, clinical recovery was observed after 245-270 minutes, after its second use - after 231-256 minutes, and after the third after 210-247 minutes (see table). Calculations showed that the weighted average duration of the clinical recovery period was 480 minutes.

Table Therapeutic efficacy of oral administration of calcium acetate in atony of the pancreas in ruminants Indicators Group control 1st experienced 2nd experienced 3rd experienced A single dose of the drug per 1 kg of body weight 0.1 ml 0.2 g 0.3 g 0.4 g Recovered animals (%) after giving the drug: 1 time 16.7 66.7 83.3 one hundred 2 times 16.7 33.3 16.7 --- 3 times 66.6 --- --- --- Recovery time (min) after giving the drug: 1 time 245-270 167-181 136-162 108-122 2 times 231-256 52-68 24-33 --- 3 times 210-247 --- --- ---

For the treatment of animals of the 1st, 2nd and 3rd experimental groups, calcium acetate was administered orally, respectively, at doses of 0.2; 0.3 and 0.4 g per 1 kg of body weight. If necessary, the drug in the same doses was prescribed again, ~ 200 min after its first use. Before each use, the required amount of calcium acetate was dissolved in water heated to the body temperature of the animal. In the first experimental group, after the first use of calcium acetate in a dose of 0.2 g per 1 kg of body weight, clinical recovery occurred in 66.7% of the animals, and after its repeated use in 33.3%. Moreover, after the first use of calcium acetate in animals, clinical recovery was observed after 167-181 minutes, and after repeated use after 52-68 minutes.

In the 2nd experimental group, after the first use of calcium acetate at a dose of 0.3 g per 1 kg of body weight, clinical recovery occurred in 83.3% of the animals, and after its repeated use in 16.7%. Moreover, after the first use of calcium acetate in animals, clinical recovery was observed after 136-162 minutes, and after repeated use after 24-33 minutes.

In the 3rd experimental group, after the first use of calcium acetate in a dose of 0.4 g per 1 kg of body weight, clinical recovery occurred in 100% of the animals. In this case, the clinical recovery of animals was noted after 108-122 minutes. Calculations showed that the weighted average duration of the clinical recovery period was 120 minutes.

Thus, calcium acetate is a highly effective therapeutic agent for atony of ruminants in the pancreas.

The optimal dose of calcium acetate was 0.4 g per 1 kg of body weight.

The use of calcium acetate in a dose of 0.4 g per 1 kg of body weight led to the recovery of all animals after the first administration of the drug and a reduction in recovery time by 4 times compared with the control.

Information sources

1. Internal non-communicable diseases of cattle. Ed. P.S. Ionova. Ed. 3rd, rev. and add. - M .: Kolos, 1985. - S.11-12.

2. Internal non-communicable diseases of farm animals. Ed. I.G. Sharabrina. Ed. 5th, fix and add. - M.: Kolos, 1976. - S.188-189.

3. Kondrakhin I.P. Diagnosis and therapy of internal diseases of animals. / I. Kondrakhin, V. Levchenko. - M .: Aquarium - Print, 2005. - P.89-91.

4. Internal non-communicable diseases of farm animals. / B.M. Anokhin, V.M. Danilevsky, L.G. Zamarin and others; Ed. V.M.Danilevsky. - M.: Agropromizdat, 1991 .-- P.190.

5. Workshop on internal diseases of animals. / Under the general editorship of Honored Scientists of the Russian Federation, Professors A.V. Korobov and G.G. Scherbakov, 2nd ed., Rev. - SPb .: Ed. "Doe", 2004. - S.120-121.

6. SU 1257890 A, 3 A61K 31/19. A method for the treatment of atony of the stomach of ruminants. / Lee A.Ch., Mametov Sh.V. Applicant and patent holder Kyrgyz Research Institute of Life Sciences. - No. 2548965 / 30-15; declared 12/01/1977; publ. 05/15. 1986 year

7. Hyperparathyroidism in chronic kidney disease. Treatment with active metabolites of vitamin D. / L. Lazarenko, A. Petrov, D. Sukhanov, M. Romantsov. // Doctor. 2005. - No. 9. - S.60-65.

8. Change in bone tissue in patients with chronic renal failure. / O. Proshkina, Y. Sorokin. // Doctor. - 2005.-№11. - S.28-30.

Claims (1)

A method for the treatment of atony of the pre-stomachs of ruminants, characterized in that the treatment is carried out by oral administration of calcium acetate in a dose of 0.2-0.4 g per 1 kg of body weight previously dissolved in water heated to the body temperature of the animal.