RU2505531C2 - Этинилиндольные соединения - Google Patents

Этинилиндольные соединения Download PDF

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Publication number
RU2505531C2
RU2505531C2 RU2009147506/04A RU2009147506A RU2505531C2 RU 2505531 C2 RU2505531 C2 RU 2505531C2 RU 2009147506/04 A RU2009147506/04 A RU 2009147506/04A RU 2009147506 A RU2009147506 A RU 2009147506A RU 2505531 C2 RU2505531 C2 RU 2505531C2
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RU
Russia
Prior art keywords
methyl
compound
phenyl
ethynyl
butoxy
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RU2009147506/04A
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English (en)
Russian (ru)
Other versions
RU2009147506A (ru
Inventor
Казуюки ОХМОТО
Сатоси ИТАДАНИ
Ёсисуке НАКАЯМА
Дзун ТАКЕУТИ
Манабу ФУДЗИТА
Original Assignee
Оно Фармасьютикал Ко., Лтд.
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Publication of RU2009147506A publication Critical patent/RU2009147506A/ru
Application granted granted Critical
Publication of RU2505531C2 publication Critical patent/RU2505531C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
RU2009147506/04A 2008-12-22 2009-12-21 Этинилиндольные соединения RU2505531C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008325815 2008-12-22
JP2008-325815 2008-12-22

Publications (2)

Publication Number Publication Date
RU2009147506A RU2009147506A (ru) 2011-06-27
RU2505531C2 true RU2505531C2 (ru) 2014-01-27

Family

ID=42110130

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009147506/04A RU2505531C2 (ru) 2008-12-22 2009-12-21 Этинилиндольные соединения

Country Status (18)

Country Link
US (1) US8115014B2 (enExample)
EP (1) EP2206698B1 (enExample)
JP (2) JP5012884B2 (enExample)
KR (1) KR101464778B1 (enExample)
CN (1) CN101759628B (enExample)
AU (1) AU2009250960C1 (enExample)
BR (1) BRPI0905601A2 (enExample)
CA (1) CA2688614C (enExample)
DK (1) DK2206698T3 (enExample)
ES (1) ES2387185T3 (enExample)
IL (1) IL202869A (enExample)
MX (1) MX2009013926A (enExample)
NZ (1) NZ582208A (enExample)
PL (1) PL2206698T3 (enExample)
PT (1) PT2206698E (enExample)
RU (1) RU2505531C2 (enExample)
TW (1) TWI469965B (enExample)
ZA (1) ZA200909096B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2560147C2 (ru) * 2010-06-21 2015-08-20 Оно Фармасьютикал Ко., Лтд. Новые кристаллические формы 4, 4'- [4-фтор-7({4-[4-(3-фтор-2-метилфенил)бутокси]фенил}этинил)-2-метил-1н-индол-1, 3-диил]дибутановой кислоты, 4, 4'-[2-метил-7-({4-[4-(пентафторфенил)бутокси] фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты и 4, 4'-[4-фтор-2-метил-7-({4-[4-(2, 3, 4, 6-тетрафторфенил) бутокси]фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101171790B1 (ko) 2010-07-30 2012-08-13 현대자동차주식회사 인출식 자전거 캐리어
ES2612492T3 (es) 2010-12-28 2017-05-17 Sanofi Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB)
EP2537866A1 (en) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
CN103893146A (zh) * 2012-12-25 2014-07-02 天津药物研究院 含福多司坦缓释剂型
US11427591B2 (en) * 2018-10-17 2022-08-30 Insilico Medicine Ip Limited Kinase inhibitors
WO2021221111A1 (ja) * 2020-04-30 2021-11-04 国立大学法人京都大学 Ｒｎａウイルス関連疾患の予防又は治療剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2107682C1 (ru) * 1990-12-12 1998-03-27 Зенека Лимитед Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов
WO2005021518A1 (ja) * 2003-09-01 2005-03-10 Ono Pharmaceutical Co., Ltd. 縮環化合物およびその用途
WO2006090817A1 (ja) * 2005-02-25 2006-08-31 Ono Pharmaceutical Co., Ltd. インドール化合物およびその用途

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US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
JPH01192476A (ja) 1988-01-25 1989-08-02 Kawasaki Steel Corp 溶接鋼管の製造方法
PT93943A (pt) 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
US5137910A (en) * 1989-05-05 1992-08-11 C.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
CA2019335C (en) 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US5530019A (en) * 1993-04-05 1996-06-25 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives useful as testosterone 5α-reductase inhibitors
DE69605128T2 (de) 1995-10-10 2000-03-02 Pfizer Inc., New York Indol-carbamate als leukotriene antagonisten
FR2766824B1 (fr) * 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2002000646A1 (en) 2000-06-27 2002-01-03 Smithkline Beecham Corporation Fatty acid synthase inhibitors
JP2003025362A (ja) 2001-07-18 2003-01-29 Nippon Tokushu Toryo Co Ltd 通気性を有する発泡プラスチック及びその製法
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
JP2005532280A (ja) 2002-04-03 2005-10-27 アストラゼネカ アクチボラグ 化合物
AU2003225131A1 (en) 2002-04-23 2003-11-10 Aventis Pharmaceuticals Inc. 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo' b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
CA2523743A1 (en) 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2107682C1 (ru) * 1990-12-12 1998-03-27 Зенека Лимитед Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов
WO2005021518A1 (ja) * 2003-09-01 2005-03-10 Ono Pharmaceutical Co., Ltd. 縮環化合物およびその用途
EP1661892A1 (en) * 2003-09-01 2006-05-31 Ono Pharmaceutical Co., Ltd. Condensed ring compound and use thereof
WO2006090817A1 (ja) * 2005-02-25 2006-08-31 Ono Pharmaceutical Co., Ltd. インドール化合物およびその用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2560147C2 (ru) * 2010-06-21 2015-08-20 Оно Фармасьютикал Ко., Лтд. Новые кристаллические формы 4, 4'- [4-фтор-7({4-[4-(3-фтор-2-метилфенил)бутокси]фенил}этинил)-2-метил-1н-индол-1, 3-диил]дибутановой кислоты, 4, 4'-[2-метил-7-({4-[4-(пентафторфенил)бутокси] фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты и 4, 4'-[4-фтор-2-метил-7-({4-[4-(2, 3, 4, 6-тетрафторфенил) бутокси]фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты

Also Published As

Publication number Publication date
JP5012884B2 (ja) 2012-08-29
BRPI0905601A2 (pt) 2012-05-02
DK2206698T3 (da) 2012-08-27
US20100160647A1 (en) 2010-06-24
AU2009250960C1 (en) 2014-01-23
AU2009250960A1 (en) 2010-07-08
JP2010168359A (ja) 2010-08-05
CA2688614A1 (en) 2010-06-22
CA2688614C (en) 2015-01-06
EP2206698A1 (en) 2010-07-14
EP2206698B1 (en) 2012-07-18
JP2012144546A (ja) 2012-08-02
CN101759628B (zh) 2013-02-27
ZA200909096B (en) 2010-09-29
RU2009147506A (ru) 2011-06-27
PT2206698E (pt) 2012-08-03
US8115014B2 (en) 2012-02-14
MX2009013926A (es) 2010-06-22
NZ582208A (en) 2011-05-27
TW201026664A (en) 2010-07-16
PL2206698T3 (pl) 2012-12-31
AU2009250960B2 (en) 2013-09-05
KR20100074036A (ko) 2010-07-01
TWI469965B (zh) 2015-01-21
ES2387185T3 (es) 2012-09-17
IL202869A (en) 2015-02-26
CN101759628A (zh) 2010-06-30
KR101464778B1 (ko) 2014-11-24

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Effective date: 20171222