JP5012884B2 - エチニルインドール化合物 - Google Patents

エチニルインドール化合物 Download PDF

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Publication number
JP5012884B2
JP5012884B2 JP2009289494A JP2009289494A JP5012884B2 JP 5012884 B2 JP5012884 B2 JP 5012884B2 JP 2009289494 A JP2009289494 A JP 2009289494A JP 2009289494 A JP2009289494 A JP 2009289494A JP 5012884 B2 JP5012884 B2 JP 5012884B2
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JP
Japan
Prior art keywords
methyl
compound
phenyl
butoxy
ethynyl
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JP2009289494A
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English (en)
Japanese (ja)
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JP2010168359A (ja
JP2010168359A5 (enExample
Inventor
和之 大元
敏 板谷
孝介 中山
淳 竹内
学 藤田
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Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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Priority to JP2009289494A priority Critical patent/JP5012884B2/ja
Publication of JP2010168359A publication Critical patent/JP2010168359A/ja
Publication of JP2010168359A5 publication Critical patent/JP2010168359A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2009289494A 2008-12-22 2009-12-21 エチニルインドール化合物 Active JP5012884B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009289494A JP5012884B2 (ja) 2008-12-22 2009-12-21 エチニルインドール化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008325815 2008-12-22
JP2008325815 2008-12-22
JP2009289494A JP5012884B2 (ja) 2008-12-22 2009-12-21 エチニルインドール化合物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012050217A Division JP2012144546A (ja) 2008-12-22 2012-03-07 エチニルインドール化合物

Publications (3)

Publication Number Publication Date
JP2010168359A JP2010168359A (ja) 2010-08-05
JP2010168359A5 JP2010168359A5 (enExample) 2011-12-08
JP5012884B2 true JP5012884B2 (ja) 2012-08-29

Family

ID=42110130

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009289494A Active JP5012884B2 (ja) 2008-12-22 2009-12-21 エチニルインドール化合物
JP2012050217A Withdrawn JP2012144546A (ja) 2008-12-22 2012-03-07 エチニルインドール化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012050217A Withdrawn JP2012144546A (ja) 2008-12-22 2012-03-07 エチニルインドール化合物

Country Status (18)

Country Link
US (1) US8115014B2 (enExample)
EP (1) EP2206698B1 (enExample)
JP (2) JP5012884B2 (enExample)
KR (1) KR101464778B1 (enExample)
CN (1) CN101759628B (enExample)
AU (1) AU2009250960C1 (enExample)
BR (1) BRPI0905601A2 (enExample)
CA (1) CA2688614C (enExample)
DK (1) DK2206698T3 (enExample)
ES (1) ES2387185T3 (enExample)
IL (1) IL202869A (enExample)
MX (1) MX2009013926A (enExample)
NZ (1) NZ582208A (enExample)
PL (1) PL2206698T3 (enExample)
PT (1) PT2206698E (enExample)
RU (1) RU2505531C2 (enExample)
TW (1) TWI469965B (enExample)
ZA (1) ZA200909096B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012025739A (ja) * 2010-06-21 2012-02-09 Ono Pharmaceut Co Ltd ４，４’−［４−フルオロ−７−（｛４−［４−（３−フルオロ−２−メチルフェニル）ブトキシ］フェニル｝エチニル）−２−メチル−１ｈ−インドール−１，３−ジイル］ジブタン酸、４，４’−［２−メチル−７−（｛４−［４−（ペンタフルオロフェニル）ブトキシ］フェニル｝エチニル）−１ｈ−インドール−１，３−ジイル］ジブタン酸および４，４’−［４−フルオロ−２−メチル−７−（｛４−［４−（２，３，４，６−テトラフルオロフェニル）ブトキシ］フェニル｝エチニル）−１ｈ−インドール−１，３−ジイル］ジブタン酸の新規結晶形

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101171790B1 (ko) 2010-07-30 2012-08-13 현대자동차주식회사 인출식 자전거 캐리어
ES2612492T3 (es) 2010-12-28 2017-05-17 Sanofi Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB)
EP2537866A1 (en) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
CN103893146A (zh) * 2012-12-25 2014-07-02 天津药物研究院 含福多司坦缓释剂型
US11427591B2 (en) * 2018-10-17 2022-08-30 Insilico Medicine Ip Limited Kinase inhibitors
WO2021221111A1 (ja) * 2020-04-30 2021-11-04 国立大学法人京都大学 Ｒｎａウイルス関連疾患の予防又は治療剤

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BE555319A (enExample) 1956-03-21 1900-01-01
US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
JPH01192476A (ja) 1988-01-25 1989-08-02 Kawasaki Steel Corp 溶接鋼管の製造方法
PT93943A (pt) 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
US5137910A (en) * 1989-05-05 1992-08-11 C.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
CA2019335C (en) 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
GB9027018D0 (en) * 1990-12-12 1991-01-30 Ici Plc Heterocyclic compounds
US5530019A (en) * 1993-04-05 1996-06-25 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives useful as testosterone 5α-reductase inhibitors
DE69605128T2 (de) 1995-10-10 2000-03-02 Pfizer Inc., New York Indol-carbamate als leukotriene antagonisten
FR2766824B1 (fr) * 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2002000646A1 (en) 2000-06-27 2002-01-03 Smithkline Beecham Corporation Fatty acid synthase inhibitors
JP2003025362A (ja) 2001-07-18 2003-01-29 Nippon Tokushu Toryo Co Ltd 通気性を有する発泡プラスチック及びその製法
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
JP2005532280A (ja) 2002-04-03 2005-10-27 アストラゼネカ アクチボラグ 化合物
AU2003225131A1 (en) 2002-04-23 2003-11-10 Aventis Pharmaceuticals Inc. 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo' b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
CA2523743A1 (en) 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
AU2004268865B8 (en) * 2003-09-01 2011-01-06 Ono Pharmaceutical Co., Ltd. Condensed ring compound and use thereof
AU2006216170B2 (en) * 2005-02-25 2012-02-09 Ono Pharmaceutical Co., Ltd. Indole compound and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012025739A (ja) * 2010-06-21 2012-02-09 Ono Pharmaceut Co Ltd ４，４’−［４−フルオロ−７−（｛４−［４−（３−フルオロ−２−メチルフェニル）ブトキシ］フェニル｝エチニル）−２−メチル−１ｈ−インドール−１，３−ジイル］ジブタン酸、４，４’−［２−メチル−７−（｛４−［４−（ペンタフルオロフェニル）ブトキシ］フェニル｝エチニル）−１ｈ−インドール−１，３−ジイル］ジブタン酸および４，４’−［４−フルオロ−２−メチル−７−（｛４−［４−（２，３，４，６−テトラフルオロフェニル）ブトキシ］フェニル｝エチニル）−１ｈ−インドール−１，３−ジイル］ジブタン酸の新規結晶形

Also Published As

Publication number Publication date
BRPI0905601A2 (pt) 2012-05-02
DK2206698T3 (da) 2012-08-27
US20100160647A1 (en) 2010-06-24
AU2009250960C1 (en) 2014-01-23
AU2009250960A1 (en) 2010-07-08
JP2010168359A (ja) 2010-08-05
CA2688614A1 (en) 2010-06-22
CA2688614C (en) 2015-01-06
EP2206698A1 (en) 2010-07-14
EP2206698B1 (en) 2012-07-18
JP2012144546A (ja) 2012-08-02
CN101759628B (zh) 2013-02-27
ZA200909096B (en) 2010-09-29
RU2009147506A (ru) 2011-06-27
PT2206698E (pt) 2012-08-03
US8115014B2 (en) 2012-02-14
MX2009013926A (es) 2010-06-22
NZ582208A (en) 2011-05-27
RU2505531C2 (ru) 2014-01-27
TW201026664A (en) 2010-07-16
PL2206698T3 (pl) 2012-12-31
AU2009250960B2 (en) 2013-09-05
KR20100074036A (ko) 2010-07-01
TWI469965B (zh) 2015-01-21
ES2387185T3 (es) 2012-09-17
IL202869A (en) 2015-02-26
CN101759628A (zh) 2010-06-30
KR101464778B1 (ko) 2014-11-24

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