RU2504552C2 - Моноклональные антитела против il-21 человека - Google Patents

Моноклональные антитела против il-21 человека Download PDF

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RU2504552C2
RU2504552C2 RU2010123049/10A RU2010123049A RU2504552C2 RU 2504552 C2 RU2504552 C2 RU 2504552C2 RU 2010123049/10 A RU2010123049/10 A RU 2010123049/10A RU 2010123049 A RU2010123049 A RU 2010123049A RU 2504552 C2 RU2504552 C2 RU 2504552C2
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antibody
cells
treatment
autoimmune
disease
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RU2010123049/10A
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Russian (ru)
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RU2010123049A (ru
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Стефэн Р. ДЖАСПЕРС
Марк У. Риксон
Стейси Р. Диллон
Фредерик Дж. РАМСДЭЛЛ
Сесил М. КРЕЙСА
Юджин С. И
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Займодженетикс, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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RU2010123049/10A 2007-12-07 2008-12-08 Моноклональные антитела против il-21 человека RU2504552C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1232907P 2007-12-07 2007-12-07
US61/012,329 2007-12-07
PCT/IB2008/005011 WO2010055366A2 (en) 2007-12-07 2008-12-08 Anti-human il-21 monoclonal antibodies

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Publication Number Publication Date
RU2010123049A RU2010123049A (ru) 2012-01-20
RU2504552C2 true RU2504552C2 (ru) 2014-01-20

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US (5) US7883700B2 (enExample)
EP (3) EP2217268B1 (enExample)
JP (3) JP5745274B2 (enExample)
KR (2) KR101591316B1 (enExample)
CN (2) CN102027011B (enExample)
AU (1) AU2008364115B2 (enExample)
BR (1) BRPI0821168B8 (enExample)
CA (2) CA2910933C (enExample)
DK (1) DK2217268T3 (enExample)
ES (2) ES2584237T3 (enExample)
HU (1) HUE027828T2 (enExample)
IL (2) IL205976A (enExample)
MX (1) MX2010006181A (enExample)
PL (1) PL2217268T3 (enExample)
PT (1) PT2217268T (enExample)
RU (1) RU2504552C2 (enExample)
WO (1) WO2010055366A2 (enExample)
ZA (1) ZA201004046B (enExample)

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RU2708336C2 (ru) * 2014-04-08 2019-12-05 Бостон Фармасьютикалс Инк. Связывающие молекулы, специфичные к ил-21, и области их применения
RU2804456C1 (ru) * 2014-04-08 2023-09-29 Бостон Фармасьютикалс Инк. Связывающие молекулы, специфичные к ил-21, и области их применения

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EP2217268B1 (en) 2007-12-07 2016-05-04 ZymoGenetics, Inc. Anti-human il-21 monoclonal antibodies
US20130224109A1 (en) * 2010-07-20 2013-08-29 Beth Israel Deaconess Medical Center, Inc. Compositions and methods featuring il-6 and il-21 antagonists
US20130323259A1 (en) * 2011-01-17 2013-12-05 Novo Nordisk A/S Il-21 ligands
WO2012164021A1 (en) 2011-05-31 2012-12-06 Novo Nordisk A/S Il-21 epitope and il-21 ligands
EP2768859B1 (en) * 2011-10-19 2018-02-21 MorphoSys AG Antagonists of il17c for the treatment of inflammatory disorders
EP2746293A1 (en) 2012-12-21 2014-06-25 Novo Nordisk A/S Anti-IL21 antibodies for use in the treatment of cardiovascular diseases
US20140178395A1 (en) * 2012-12-21 2014-06-26 Novo Nordisk A/S Treatment of nephropathy
WO2014205501A1 (en) * 2013-06-27 2014-12-31 Monash University Il-21 binding proteins and uses thereof
CN103487572B (zh) * 2013-10-08 2017-03-29 北京大学人民医院 滤泡辅助性T淋巴细胞(Tfh)在自身免疫性疾病病情预警中的应用
CN104721820A (zh) * 2013-12-24 2015-06-24 信达生物制药(苏州)有限公司 双特异性单克隆抗体在治疗葡萄膜炎中的用途
WO2015132241A1 (en) * 2014-03-03 2015-09-11 Novo Nordisk A/S Treatment of inflammatory diseases
AR099625A1 (es) 2014-03-21 2016-08-03 Lilly Co Eli Anticuerpos de il-21
PT3139948T (pt) * 2014-05-07 2020-05-22 Novo Nordisk As Tratamento de diabetes usando glp-1 e anti-il-21
JP6672175B2 (ja) * 2014-05-07 2020-03-25 ノヴォ ノルディスク アー／エス Ｇｌｐ−１及び抗ｉｌ−２１を使用した１型糖尿病の治療
RU2609627C2 (ru) * 2014-09-26 2017-02-02 Закрытое Акционерное Общество "Биокад" Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
CN107249633A (zh) * 2014-12-19 2017-10-13 迈博太科公司 用于抑制il‑21介导的人细胞活化的组合物、试剂盒和方法
EP3233120A4 (en) 2014-12-19 2018-05-30 Monash University Il-21 antibodies
CA3018792C (en) 2016-03-31 2023-03-28 Eli Lilly And Company Il-21 antibodies and uses thereof
US20190185559A1 (en) * 2016-09-02 2019-06-20 The Brigham And Women's Hospital, Inc. Compositions and methods for treating neoplasias
JP6952295B2 (ja) * 2016-09-09 2021-10-20 国立大学法人金沢大学 ヒト抗ｈｌａモノクローナル抗体の作製方法
CN118126157A (zh) 2017-08-03 2024-06-04 美国安进公司 白介素-21突变蛋白和治疗方法
MX2020007291A (es) 2018-01-12 2020-09-10 Amgen Inc Anticuerpos anti-pd-1 y metodos de tratamiento.
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
KR20230038496A (ko) * 2020-07-13 2023-03-20 트랜스진 면역 억제의 치료
CN118370816A (zh) * 2024-03-22 2024-07-23 中日友好医院(中日友好临床医学研究所) Il-2/抗il-2抗体免疫复合物的应用
WO2025257327A1 (en) 2024-06-13 2025-12-18 Almirall, S.A. Therapeutic approaches for the management of hidradenitis suppurativa

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