RU2493252C2 - Способ стимулирования экспансии гематопоэтических стволовых клеток - Google Patents
Способ стимулирования экспансии гематопоэтических стволовых клеток Download PDFInfo
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- RU2493252C2 RU2493252C2 RU2011115827/10A RU2011115827A RU2493252C2 RU 2493252 C2 RU2493252 C2 RU 2493252C2 RU 2011115827/10 A RU2011115827/10 A RU 2011115827/10A RU 2011115827 A RU2011115827 A RU 2011115827A RU 2493252 C2 RU2493252 C2 RU 2493252C2
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| EP3533445A1 (en) * | 2009-03-19 | 2019-09-04 | Fate Therapeutics, Inc. | Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same |
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| US11459545B2 (en) | 2009-11-15 | 2022-10-04 | Indiana University Research And Technology Corporation | Methods to enhance delivery and engraftment of stem cells including the identification of specific prostaglandin E2 receptors |
| US20130129686A1 (en) * | 2009-11-19 | 2013-05-23 | Regents Of The University | Reducing Inflammation Using Cell Therapy |
| JP2013528373A (ja) * | 2010-05-10 | 2013-07-11 | フェイト セラピューティクス,インコーポレイテッド | 生物学的な用途のための容器 |
| CN103167876B (zh) * | 2010-08-12 | 2016-08-31 | 菲特治疗公司 | 改进的造血干细胞和祖细胞疗法 |
| PL2663313T3 (pl) * | 2011-01-13 | 2019-01-31 | SciPharm S.à r.l. | Sposób zwiększania wszczepiania hematopoetycznych komórek macierzystych |
| WO2012149547A1 (en) * | 2011-04-28 | 2012-11-01 | Duke University | Methods of treating hemoglobinopathies |
| CA2850484C (en) | 2011-09-30 | 2021-01-26 | Bluebird Bio, Inc. | Compounds for improved viral transduction |
| EP2785350B1 (en) | 2011-12-02 | 2018-05-02 | Fate Therapeutics, Inc. | Improved methods of treating ischemia |
| CN104066837B (zh) | 2011-12-02 | 2020-12-08 | 菲特治疗公司 | 增强的干细胞组合物 |
| US9428732B2 (en) | 2011-12-05 | 2016-08-30 | Primorigen Biosciences, Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
| WO2014015318A1 (en) * | 2012-07-19 | 2014-01-23 | Bluebird Bio, Inc. | Soluble compounds for improved gene therapy methods |
| US9861685B2 (en) | 2012-11-20 | 2018-01-09 | Duke University | Methods of treating hemoglobinopathies |
| US9943545B2 (en) * | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9428748B2 (en) * | 2013-06-17 | 2016-08-30 | Hong Gao | Method of expanding hematopoietic stem cells |
| JP2015205835A (ja) * | 2014-04-21 | 2015-11-19 | 国立大学法人福井大学 | 中性子線障害防護剤 |
| CA2946747A1 (en) * | 2014-04-23 | 2015-10-29 | Texas Heart Institute | Methods of enhancing stem cell engraftment |
| WO2016014794A1 (en) | 2014-07-25 | 2016-01-28 | Sangamo Biosciences, Inc. | Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells |
| CN113699113A (zh) | 2014-09-16 | 2021-11-26 | 桑格摩治疗股份有限公司 | 用于造血干细胞中核酸酶介导的基因组工程化和校正的方法和组合物 |
| US10626372B1 (en) | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP6980534B2 (ja) | 2015-06-25 | 2021-12-15 | ザ チルドレンズ メディカル センター コーポレーション | 造血幹細胞の増大、富化、および維持に関する方法および組成物 |
| BR112018001232A2 (pt) | 2015-07-21 | 2018-09-25 | The Children's Medical Center Corporation | pd-l1 que expressa células-tronco hematopoéticas e usos |
| CN105296427A (zh) * | 2015-10-23 | 2016-02-03 | 深圳爱生再生医学科技有限公司 | 造血干细胞的体外扩增培养方法 |
| JP7189587B2 (ja) * | 2015-10-30 | 2022-12-14 | 典正 三浦 | メチル化関連酵素hat1とkat8の阻害薬 |
| CN122146606A (zh) | 2015-11-04 | 2026-06-05 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| US12642852B1 (en) | 2015-11-04 | 2026-06-02 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| KR20250134722A (ko) | 2016-02-12 | 2025-09-11 | 블루버드 바이오, 인코포레이티드. | Vcn 인핸서 조성물 및 이의 사용 방법 |
| CN108883136A (zh) | 2016-02-12 | 2018-11-23 | 蓝鸟生物公司 | Vcn增强子组合物及其使用方法 |
| EP4538365A3 (en) * | 2016-03-04 | 2025-07-30 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for muscle regeneration using prostaglandin e2 |
| WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| WO2018093797A1 (en) | 2016-11-15 | 2018-05-24 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| EP3634425A4 (en) * | 2017-06-07 | 2021-04-07 | Academia Sinica | METHOD OF ELIMINATION OF UNDIFFERENTIATED PLURIPOTENT STEM CELLS |
| GB2578539B (en) | 2017-06-09 | 2022-08-10 | Univ Leland Stanford Junior | Compositions and methods for preventing or treating muscle conditions |
| US12215351B2 (en) | 2017-08-22 | 2025-02-04 | The Children's Medical Center Corporation | Methods for inducing hematopoietic stem cell specificity |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| CA3082643A1 (en) | 2017-11-14 | 2019-05-23 | The Schepens Eye Research Institute, Inc. | Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| EP3597211A1 (en) | 2018-07-19 | 2020-01-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Periostin compounds for the treatment of haematological complications |
| CN109609455A (zh) * | 2018-12-28 | 2019-04-12 | 诺未科技(北京)有限公司 | 扩增造血干细胞的培养体系、方法及其用途 |
| WO2020167948A1 (en) * | 2019-02-13 | 2020-08-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for stem cell therapy |
| CN110051839A (zh) * | 2019-04-16 | 2019-07-26 | 诺航生物技术(徐州)有限公司 | 一种促进脐带血干细胞体外扩增和增强脐带血干细胞移植后造血重建功能的药物 |
| JP7853100B2 (ja) | 2019-06-05 | 2026-04-28 | オーチャード セラピューティクス(ヨーロッパ)リミテッド | 真核細胞を修飾するための組成物及び方法 |
| FI130749B1 (en) * | 2020-01-24 | 2024-02-26 | Faron Pharmaceuticals Oy | USE OF VAP-1 INHIBITOR IN THE EX VIVO CULTURE OF HEMATOPOEITIC STEM CELLS AND IN THE TREATMENT OF BONE Marrow Loss or BONE Marrow Dysfunction |
| WO2021216378A1 (en) | 2020-04-23 | 2021-10-28 | The Schepens Eye Research Institute, Inc. | Methods and materials for treatment of fibrosis |
| EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
| US11883436B2 (en) | 2020-08-17 | 2024-01-30 | The Board Of Trustees Of The University Of Illinois | Method of preparing hematopoietic stem and progenitor cells for transplantation |
| AU2021202658A1 (en) | 2021-04-28 | 2022-11-17 | Fondazione Telethon | Gene therapy |
| GB202206346D0 (en) | 2022-04-29 | 2022-06-15 | Ospedale San Raffaele Srl | Gene therapy |
| WO2023244470A1 (en) * | 2022-06-14 | 2023-12-21 | The Children's Medical Center Corporation | Surface calr chemical inducers |
| KR20240136869A (ko) | 2023-03-07 | 2024-09-19 | 인제대학교 산학협력단 | 조혈 줄기세포 증식 또는 가동화 촉진용 조성물 및 가동화 조혈 줄기세포 수집방법 |
| CN116355836B (zh) * | 2023-04-07 | 2026-05-19 | 上海市东方医院(同济大学附属东方医院) | 胆管树干细胞的扩增或传代体系及其应用 |
| US20250332260A1 (en) | 2024-04-10 | 2025-10-30 | Garuda Therapeutics, Inc. | Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2205627C1 (ru) * | 2002-05-30 | 2003-06-10 | Открытое акционерное общество "Косметическое объединение "Свобода" | Крем для лица, выводящий токсины |
| US20050054103A1 (en) * | 2003-03-07 | 2005-03-10 | Tony Peled | Expansion of renewable stem cell populations using modulators of PI 3-kinase |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA103846A (en) | 1906-12-03 | 1907-02-26 | William Bell | Manufacture of half-tone printing blocks |
| US3217903A (en) | 1961-01-19 | 1965-11-16 | Mc Graw Edison Co | Segregating control |
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4239679A (en) | 1979-06-27 | 1980-12-16 | Diamond Shamrock Corporation | High bulk density rigid poly(vinyl chloride) resin powder composition and preparation thereof |
| HU181154B (en) | 1980-07-18 | 1983-06-28 | Epitestudomanyi Intezet | Shaped building unit and space limiting or dividing structure made of same as well as method for producing the shaped building unit |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| EP0676470A1 (en) * | 1989-10-16 | 1995-10-11 | Amgen Inc. | Stem cell factor |
| US5114672A (en) | 1990-08-27 | 1992-05-19 | Cryo-Cell International, Inc. | Method for preserving blood fluid |
| AU702871B2 (en) * | 1993-08-23 | 1999-03-11 | Nexell Therapeutics Inc. | (In vitro) growth of neutrophil and megakaryocyte precursors in serum-free media |
| AU6125396A (en) * | 1995-06-07 | 1996-12-30 | Novartis Ag | Serum-free media for primitive hematopoietic cells and metho ds of use thereof |
| US6372796B1 (en) | 1996-11-13 | 2002-04-16 | Cold Spring Harbor Laboratory | Therapeutic uses for nitric oxide inhibitors |
| GB9904281D0 (en) | 1999-02-24 | 1999-04-21 | Reneuron Ltd | Transplantation |
| TWI247606B (en) | 1999-11-24 | 2006-01-21 | Ono Pharmaceutical Co | Treating agent for osteopenic diseases |
| BR0015781A (pt) | 1999-11-24 | 2002-12-31 | Ono Pharmaceutical Co | Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea |
| US6226997B1 (en) | 1999-12-07 | 2001-05-08 | Cryo-Cell International, Inc. | Method and device for maintaining temperature integrity of cryogenically preserved biological samples |
| US6852534B2 (en) | 2000-11-03 | 2005-02-08 | Kourion Therapeutics Gmbh | Method to determine an engrafting cell dose of hematopoietic stem cell transplant units |
| JP4077158B2 (ja) | 2001-01-10 | 2008-04-16 | 株式会社メニコン | 植物性繊維分解剤およびそれを用いた植物性廃棄物の処理法 |
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| FR2825261B1 (fr) | 2001-06-01 | 2003-09-12 | Maco Pharma Sa | Ligne de prelevement du sang placentaire comprenant une poche de rincage |
| US7179643B2 (en) | 2001-06-14 | 2007-02-20 | Reliance Life Sciences Pvt. Ltd. | Device and a process for expansion of haemopoeitic stem cells for therapeutic use |
| US8021876B2 (en) | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| AU2002350352A1 (en) * | 2001-12-21 | 2003-07-15 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| HUE029417T2 (en) | 2002-10-10 | 2017-02-28 | Ono Pharmaceutical Co | Microspheres containing ONO-1301 |
| AU2004216898A1 (en) | 2003-03-04 | 2004-09-16 | Pfizer Products Inc. | Use of EP2 selective receptor agonists in medical treatment |
| JP4865541B2 (ja) | 2003-04-08 | 2012-02-01 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 化学誘引物質に対する増大させた感受性を有する幹細胞およびそれを産生および使用する方法 |
| GB0324523D0 (en) * | 2003-10-21 | 2003-11-26 | Medical Res Council | Compositions and methods of treatment |
| US8309608B2 (en) | 2003-11-06 | 2012-11-13 | Sanofi-Aventis Deutschland Gmbh | Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases |
| IL158868A0 (en) | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
| CA2573176A1 (en) * | 2004-07-09 | 2006-01-19 | Bc Cancer Agency | Nup98-hox fusions for expansion of hemopoietic stem cells |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| WO2006078886A2 (en) | 2005-01-18 | 2006-07-27 | Irm Llc | Compounds and compositions as wnt signaling pathway modulators |
| EP1859028B1 (en) | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Vascular endothelial cells |
| US20080194024A1 (en) | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
| JP4562618B2 (ja) | 2005-08-18 | 2010-10-13 | 陽一 佐藤 | 空き缶処理車 |
| GB2447191B (en) * | 2005-12-22 | 2011-08-03 | Es Cell Int Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| EP1999255A2 (en) | 2006-03-24 | 2008-12-10 | The Children's Medical Center Corporation | Method to modulate hematopoietic stem cell growth |
| WO2007148332A1 (en) | 2006-06-22 | 2007-12-27 | Yeda Resaerch And Development Co. Ltd | Catecholamine receptor modulation |
| WO2008021475A2 (en) | 2006-08-16 | 2008-02-21 | The General Hospital Corporation | Compositions and methods for hematopoietic stem cell expansion or for modulating angiogenesis |
| KR20080042761A (ko) | 2006-11-10 | 2008-05-15 | 문찬일 | 렙틴을 이용한 줄기세포 증식방법 |
| EP2094839B1 (en) * | 2006-12-08 | 2020-02-05 | University of Rochester | Expansion of hematopoietic stem cells |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2205627C1 (ru) * | 2002-05-30 | 2003-06-10 | Открытое акционерное общество "Косметическое объединение "Свобода" | Крем для лица, выводящий токсины |
| US20050054103A1 (en) * | 2003-03-07 | 2005-03-10 | Tony Peled | Expansion of renewable stem cell populations using modulators of PI 3-kinase |
Non-Patent Citations (4)
| Title |
|---|
| COHN S M et al. Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1// JOURNAL OF CLINICAL INVESTIGATI n.6, p.1367-1379. * |
| FEHER I. еt al. Prostaglandin E2 as stimulator of haemopoietic stem cell proliferation, Nature. 1974, v.247, no.442, pp.550-551. * |
| HANSON W R et al. "16, 16-DIMETHYLPROSTAGLANDIN E-2 INDUCES RADIOPROTECTION IN MURINE INTESTINAL AND HEMATOPOIETIC STEM CELLS" RADIATION RESEARCH, ACADEMIC PRESS INC, 1985, v. 103, n.2, p.196-203. * |
| HANSON W R et al. "16, 16-DIMETHYLPROSTAGLANDIN E-2 INDUCES RADIOPROTECTION IN MURINE INTESTINAL AND HEMATOPOIETIC STEM CELLS" RADIATION RESEARCH, ACADEMIC PRESS INC, 1985, v. 103, n.2, p.196-203. COHN S M et al. Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1// JOURNAL OF CLINICAL INVESTIGATION. - 1997, v.99, n.6, p.1367-1379. * |
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