RU2476432C2 - 6-, 7- или 8-замещенные производные хиназолинона и композиции, включающие их, и способы их использования - Google Patents

6-, 7- или 8-замещенные производные хиназолинона и композиции, включающие их, и способы их использования Download PDF

Info

Publication number
RU2476432C2
RU2476432C2 RU2010116273/04A RU2010116273A RU2476432C2 RU 2476432 C2 RU2476432 C2 RU 2476432C2 RU 2010116273/04 A RU2010116273/04 A RU 2010116273/04A RU 2010116273 A RU2010116273 A RU 2010116273A RU 2476432 C2 RU2476432 C2 RU 2476432C2
Authority
RU
Russia
Prior art keywords
mmol
methyl
optionally substituted
alkyl
oxo
Prior art date
Application number
RU2010116273/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2010116273A (ru
Inventor
Джордж В. Мюллер
Хон-Вах МАН
Original Assignee
Селджин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of RU2010116273A publication Critical patent/RU2010116273A/ru
Application granted granted Critical
Publication of RU2476432C2 publication Critical patent/RU2476432C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2010116273/04A 2007-09-26 2008-09-25 6-, 7- или 8-замещенные производные хиназолинона и композиции, включающие их, и способы их использования RU2476432C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99567607P 2007-09-26 2007-09-26
US60/995,676 2007-09-26
PCT/US2008/011124 WO2009042177A1 (en) 2007-09-26 2008-09-25 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same

Publications (2)

Publication Number Publication Date
RU2010116273A RU2010116273A (ru) 2011-11-10
RU2476432C2 true RU2476432C2 (ru) 2013-02-27

Family

ID=40225265

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2010116273/04A RU2476432C2 (ru) 2007-09-26 2008-09-25 6-, 7- или 8-замещенные производные хиназолинона и композиции, включающие их, и способы их использования

Country Status (21)

Country Link
US (5) US8492395B2 (enExample)
EP (1) EP2200999B1 (enExample)
JP (1) JP5637852B2 (enExample)
KR (1) KR101593242B1 (enExample)
CN (2) CN101952272B (enExample)
AU (1) AU2008305581C1 (enExample)
BR (1) BRPI0817525A2 (enExample)
CA (1) CA2704710C (enExample)
CO (1) CO6270228A2 (enExample)
CR (1) CR11355A (enExample)
ES (1) ES2523925T3 (enExample)
IL (2) IL204763A (enExample)
MX (1) MX347987B (enExample)
MY (1) MY157495A (enExample)
NI (1) NI201000041A (enExample)
NZ (1) NZ584425A (enExample)
RU (1) RU2476432C2 (enExample)
SG (2) SG176442A1 (enExample)
UA (1) UA102078C2 (enExample)
WO (1) WO2009042177A1 (enExample)
ZA (1) ZA201002303B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2066656E (pt) 2006-09-26 2012-06-28 Celgene Corp Derivados de quinazolina substituídos em 5 como agentes antitumorais
US8354417B2 (en) * 2007-09-26 2013-01-15 Celgene Corporation Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same
NZ598462A (en) * 2009-08-31 2012-12-21 Merck Sharp & Dohme Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
EP2490692B1 (en) 2009-10-21 2016-11-16 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone m1 receptor positive allosteric modulators
PL2683384T3 (pl) * 2011-03-11 2016-06-30 Celgene Corp Sposoby leczenia nowotworu z użyciem 3-(5-amino-2-metylo-4-okso-4h-chinazolin-3-ylo)piperydyno-2,6-dionu
CA3037184C (en) 2011-03-11 2021-04-06 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
WO2012135299A1 (en) 2011-03-28 2012-10-04 Deuteria Pharmaceuticals Inc 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
JP6359563B2 (ja) 2013-01-14 2018-07-18 デュートルクス・リミテッド・ライアビリティ・カンパニーDeuteRx, LLC 3−(5置換−4−オキソキナゾリン−3(4h)−イル)−3−ジュウテロピペリジン−2,6−ジオン誘導体
CA2941560A1 (en) 2013-03-14 2014-09-25 Deuterx, Llc 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
HK1221174A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包括tor激酶抑制剂和5-取代喹唑啉酮化合物的组合疗法
WO2014179661A1 (en) 2013-05-03 2014-11-06 Celgene Corporation Methods for treating cancer using combination therapy
EP3925609B1 (en) 2014-08-22 2025-07-30 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
BR112017028530A2 (pt) 2015-07-02 2018-08-28 Celgene Corp terapia combinada para tratamento de cânceres hematológicos e tumores sólidos
US9809603B1 (en) 2015-08-18 2017-11-07 Deuterx, Llc Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
US11001566B2 (en) * 2016-01-14 2021-05-11 Kangpu Biopharmaceuticals, Ltd. Quinazolinone derivative, preparation method therefor, pharmaceutical composition, and applications
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
WO2018208123A1 (ko) * 2017-05-12 2018-11-15 한국화학연구원 신규한 피페리딘-2,6-디온 유도체 및 이의 용도
KR102014478B1 (ko) * 2017-05-12 2019-08-26 한국화학연구원 신규한 피페리딘-2,6-디온 유도체 및 이의 용도
WO2018237026A1 (en) 2017-06-20 2018-12-27 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
EP3679027A1 (en) 2017-09-04 2020-07-15 C4 Therapeutics, Inc. Dihydrobenzimidazolones
WO2019043214A1 (en) 2017-09-04 2019-03-07 F. Hoffmann-La Roche Ag glutarimide
WO2019043208A1 (en) 2017-09-04 2019-03-07 F. Hoffmann-La Roche Ag DIHYDROQUINOLINONES
CN111885914B (zh) * 2017-10-27 2022-05-13 投资健康有限责任公司 使用芴衍生物制造扩增的造血干细胞的组合物和方法
CN111372585A (zh) 2017-11-16 2020-07-03 C4医药公司 用于靶蛋白降解的降解剂和降解决定子
JP2021519337A (ja) 2018-03-26 2021-08-10 シー4 セラピューティクス, インコーポレイテッド Ikarosの分解のためのセレブロン結合剤
CN119751456A (zh) 2018-04-16 2025-04-04 C4医药公司 螺环化合物
EP3578561A1 (en) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
WO2020132561A1 (en) 2018-12-20 2020-06-25 C4 Therapeutics, Inc. Targeted protein degradation
MX2021012524A (es) 2019-04-12 2021-11-12 C4 Therapeutics Inc Degradadores triciclicos de ikaros y aiolos.
US11807620B2 (en) 2020-02-21 2023-11-07 Plexium, Inc. Quinazolinone compounds and related compounds
US20230303539A1 (en) * 2020-08-14 2023-09-28 Shanghaitech University Immunoregulatory compound and antitumor application thereof
WO2023287726A1 (en) 2021-07-12 2023-01-19 Penland Foundation Treatment of cancer using botulinum toxin and nitrous oxide
CN119325475A (zh) 2022-06-06 2025-01-17 C4医药公司 双环取代的戊二酰亚胺cereblon结合剂

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635517A (en) * 1996-07-24 1997-06-03 Celgene Corporation Method of reducing TNFα levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines
WO1999047512A1 (en) * 1998-03-16 1999-09-23 Colgene Corporation 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
EA002905B1 (ru) * 1996-05-15 2002-10-31 Пфайзер Инк. 2,3-двузамещенные-4(3н)-хиназолиноны и содержащая их фармацевтическая композиция
US20030220227A1 (en) * 2002-03-15 2003-11-27 Timur Gungor 3-Arylquinazoline derivatives as selective estrogen receptor beta modulators

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5770589A (en) 1993-07-27 1998-06-23 The University Of Sydney Treatment of macular degeneration
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
IT1274549B (it) 1995-05-23 1997-07-17 Indena Spa Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
US5800819A (en) 1996-01-25 1998-09-01 National Institute For Pharmaceutical Research And Development Federal Ministry Of Science And Technology Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease
DE69740140D1 (de) 1996-07-24 2011-04-14 Celgene Corp Substituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide und Oxoisoindoline und Verfahren zur Verringerung der TNF-Alpha-Stufen
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US6015803A (en) 1998-05-04 2000-01-18 Wirostko; Emil Antibiotic treatment of age-related macular degeneration
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
US6001368A (en) 1998-09-03 1999-12-14 Protein Technologies International, Inc. Method for inhibiting or reducing the risk of macular degeneration
US7182953B2 (en) 1999-12-15 2007-02-27 Celgene Corporation Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
WO2003041326A2 (en) 2001-11-09 2003-05-15 Matsushita Electric Industrial Co., Ltd. Moving picture coding method and apparatus
US7323479B2 (en) 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US7393862B2 (en) 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
EP1537089A4 (en) * 2002-07-23 2008-04-16 Cytokinetics Inc CONNECTIONS, COMPOSITIONS AND PROCEDURES
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US20050203142A1 (en) 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040091455A1 (en) 2002-10-31 2004-05-13 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
GB0324790D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US20050100529A1 (en) 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
US20050143420A1 (en) 2003-12-02 2005-06-30 Moutouh-De Parseval Laure Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US20050143344A1 (en) 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
CA2560221C (en) 2004-03-22 2010-12-07 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders
MXPA06011236A (es) * 2004-04-02 2007-01-16 Prana Biotechnology Ltd Compuestos neurologicamente activos.
ZA200609226B (en) 2004-04-23 2008-06-25 Celgene Corp Methods of using and compositions comprising immuno-modulatory compounds for the treatment and management of pulmonary hypertension
KR20070028536A (ko) * 2004-06-15 2007-03-12 아스트라제네카 아베 항암제로서의 치환된 퀴나졸론
AU2005304420A1 (en) 2004-11-12 2006-05-18 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
CN101102771A (zh) 2004-11-23 2008-01-09 细胞基因公司 用免疫调节化合物治疗和控制中枢神经系统损伤的方法和组合物
WO2006060507A2 (en) 2004-12-01 2006-06-08 Celgene Corporation Compositions comprising immunomodulatory compounds and the use thereof for the treatment of immunodeficiency disorders
ES2434946T3 (es) 2005-08-31 2013-12-18 Celgene Corporation Compuestos de isoindol imida y composiciones que los comprenden y métodos para usarlo
DK1928492T3 (da) 2005-09-01 2011-06-06 Celgene Corp Immunologiske anvendelser af immunmodulatoriske forbindelser til vaccine og terapi mod infektionssygdomme
PT2066656E (pt) * 2006-09-26 2012-06-28 Celgene Corp Derivados de quinazolina substituídos em 5 como agentes antitumorais

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002905B1 (ru) * 1996-05-15 2002-10-31 Пфайзер Инк. 2,3-двузамещенные-4(3н)-хиназолиноны и содержащая их фармацевтическая композиция
US5635517A (en) * 1996-07-24 1997-06-03 Celgene Corporation Method of reducing TNFα levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
WO1999047512A1 (en) * 1998-03-16 1999-09-23 Colgene Corporation 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
US20030220227A1 (en) * 2002-03-15 2003-11-27 Timur Gungor 3-Arylquinazoline derivatives as selective estrogen receptor beta modulators

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
El-Fattah В ABD et al. Synthesiss and screening of some quinazolinone derivatives // Bulletin of The Faculty Of Pharmacy (Cairo University) XX, XX, 1976, 273-284. *
Joensson N.A. et al. Chemical structure and teratogenic properties. Part 2: synthesis and teratogenic activity in rabbits of some derivatives of phthalimide, isoindoline-1-one, 1,2-benzisothiazoline-3-one-1,1-dioxide and 4(3H)-quinazolinone // Acta Pharmaceutica, XX, vol.9, 1972, p.431-446; см. р.435. *
Joensson N.A. et al. Chemical structure and teratogenic properties. Part 2: synthesis and teratogenic activity in rabbits of some derivatives of phthalimide, isoindoline-1-one, 1,2-benzisothiazoline-3-one-1,1-dioxide and 4(3H)-quinazolinone // Acta Pharmaceutica, XX, vol.9, 1972, p.431-446; см. р.435. El-Fattah В ABD et al. Synthesiss and screening of some quinazolinone derivatives // Bulletin of The Faculty Of Pharmacy (Cairo University) XX, XX, 1976, 273-284. *

Also Published As

Publication number Publication date
BRPI0817525A2 (pt) 2014-11-18
JP5637852B2 (ja) 2014-12-10
CA2704710C (en) 2016-02-02
US9834538B2 (en) 2017-12-05
CA2704710A1 (en) 2009-04-02
CN101952272A (zh) 2011-01-19
WO2009042177A1 (en) 2009-04-02
ES2523925T3 (es) 2014-12-02
US9096573B2 (en) 2015-08-04
MX2010003355A (es) 2010-04-14
IL204763A0 (en) 2010-11-30
CN101952272B (zh) 2014-08-27
IL204763A (en) 2013-07-31
US20130289274A1 (en) 2013-10-31
AU2008305581C1 (en) 2014-12-11
SG176442A1 (en) 2011-12-29
MX347987B (es) 2017-05-22
UA102078C2 (ru) 2013-06-10
US9586929B2 (en) 2017-03-07
NI201000041A (es) 2010-09-09
ZA201002303B (en) 2011-06-29
US20090093504A1 (en) 2009-04-09
AU2008305581A1 (en) 2009-04-02
KR101593242B1 (ko) 2016-02-11
IL226870A (en) 2014-11-30
JP2010540525A (ja) 2010-12-24
CO6270228A2 (es) 2011-04-20
US20170129873A1 (en) 2017-05-11
EP2200999A1 (en) 2010-06-30
CR11355A (es) 2010-06-21
MY157495A (en) 2016-06-15
US20180118713A1 (en) 2018-05-03
HK1139934A1 (en) 2010-09-30
IL226870A0 (en) 2013-07-31
KR20100080540A (ko) 2010-07-08
SG10201503486XA (en) 2015-06-29
US8492395B2 (en) 2013-07-23
NZ584425A (en) 2012-03-30
EP2200999B1 (en) 2014-08-13
CN104211684A (zh) 2014-12-17
AU2008305581B2 (en) 2013-12-05
US20150291555A1 (en) 2015-10-15
RU2010116273A (ru) 2011-11-10

Similar Documents

Publication Publication Date Title
RU2476432C2 (ru) 6-, 7- или 8-замещенные производные хиназолинона и композиции, включающие их, и способы их использования
RU2617989C2 (ru) Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения
RU2471794C2 (ru) 4'-о-замещенные изоиндолиновые производные и содержащие их композиции и способы их применения
ES2361584T3 (es) Compuestos de n-metilaminometil-isoindol y composiciones que los comprenden y métodos que usan los mismos.
RU2448101C2 (ru) 5-замещенные изоиндолиновые соединения
HK1139934B (en) 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
HK1167398B (en) 5-substituted quinazolinone derivatives as anti-cancer agents

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20190926