RU2468024C2 - ИНГИБИТОРЫ FXa С ЦИКЛИЧЕСКИМ АМИДОКСИМОМ ИЛИ ЦИКЛИЧЕСКИМ АМИДРАЗОНОМ В КАЧЕСТВЕ P4 СУБЪЕДИНИЦЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ПРОИЗВОДНЫЕ - Google Patents
ИНГИБИТОРЫ FXa С ЦИКЛИЧЕСКИМ АМИДОКСИМОМ ИЛИ ЦИКЛИЧЕСКИМ АМИДРАЗОНОМ В КАЧЕСТВЕ P4 СУБЪЕДИНИЦЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ПРОИЗВОДНЫЕ Download PDFInfo
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- RU2468024C2 RU2468024C2 RU2011103766/04A RU2011103766A RU2468024C2 RU 2468024 C2 RU2468024 C2 RU 2468024C2 RU 2011103766/04 A RU2011103766/04 A RU 2011103766/04A RU 2011103766 A RU2011103766 A RU 2011103766A RU 2468024 C2 RU2468024 C2 RU 2468024C2
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229960000216 tenecteplase Drugs 0.000 description 1
- ACNRTYKOPZDRCO-UHFFFAOYSA-N tert-butyl n-(2-oxoethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCC=O ACNRTYKOPZDRCO-UHFFFAOYSA-N 0.000 description 1
- DKACXUFSLUYRFU-UHFFFAOYSA-N tert-butyl n-aminocarbamate Chemical compound CC(C)(C)OC(=O)NN DKACXUFSLUYRFU-UHFFFAOYSA-N 0.000 description 1
- MSWTVSDFEYSRMQ-UHFFFAOYSA-N tert-butyl n-methyl-n-(2-oxoethyl)carbamate Chemical compound O=CCN(C)C(=O)OC(C)(C)C MSWTVSDFEYSRMQ-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 description 1
- 229960001522 ximelagatran Drugs 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080064178A KR100898361B1 (ko) | 2008-07-03 | 2008-07-03 | Ｐ4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 ＦＸａ 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물 |
| KR10-2008-0064178 | 2008-07-03 | ||
| PCT/KR2009/003008 WO2010002115A2 (en) | 2008-07-03 | 2009-06-05 | Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof |
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|---|---|
| RU2011103766A RU2011103766A (ru) | 2012-08-10 |
| RU2468024C2 true RU2468024C2 (ru) | 2012-11-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011103766/04A RU2468024C2 (ru) | 2008-07-03 | 2009-06-05 | ИНГИБИТОРЫ FXa С ЦИКЛИЧЕСКИМ АМИДОКСИМОМ ИЛИ ЦИКЛИЧЕСКИМ АМИДРАЗОНОМ В КАЧЕСТВЕ P4 СУБЪЕДИНИЦЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ПРОИЗВОДНЫЕ |
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| Country | Link |
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| US (1) | US8178525B2 (es) |
| EP (1) | EP2307407B1 (es) |
| JP (1) | JP5325289B2 (es) |
| KR (1) | KR100898361B1 (es) |
| CN (1) | CN102083825B (es) |
| AU (1) | AU2009266631B2 (es) |
| BR (1) | BRPI0915326B8 (es) |
| CA (1) | CA2728350C (es) |
| CL (1) | CL2010001618A1 (es) |
| ES (1) | ES2566755T3 (es) |
| IL (1) | IL210384A (es) |
| MX (1) | MX2010013969A (es) |
| MY (1) | MY165573A (es) |
| NZ (1) | NZ590315A (es) |
| RU (1) | RU2468024C2 (es) |
| UA (1) | UA97598C2 (es) |
| WO (1) | WO2010002115A2 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663617C1 (ru) * | 2014-07-18 | 2018-08-07 | Грин Кросс Корпорейшн | Новая кристаллическая форма метансульфонат 5-хлор-n-({ (5s)-2-оксо-3-[4-(5,6-дигидро-4h-[1,2,4]триазин-1-ил)фенил]-1,3-оксазолидин-5-ил} метил)тиофен-2-карбоксамида и содержащая его фармацевтическая композиция |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101023174B1 (ko) * | 2008-09-24 | 2011-03-18 | 주식회사 레고켐 바이오사이언스 | 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| KR101037051B1 (ko) | 2009-07-08 | 2011-05-26 | 주식회사 레고켐 바이오사이언스 | (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법 |
| KR101037052B1 (ko) * | 2009-07-08 | 2011-05-26 | 주식회사 레고켐 바이오사이언스 | 5-클로로-ｎ-(((5ｓ)-2-옥소-3-(4-(5,6-디하이드로-1,2,4-트리아진-1(4ｈ)-일)페닐)-1,3-옥사졸리딘-5-일)메틸)티오펜-2-카르복사미드 유도체의 제조방법 및 그 제조중간체 |
| GEP20156397B (en) * | 2011-05-06 | 2015-11-10 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Process for the preparation of a rivaroxaban and intermediates formed in said process |
| US8877628B2 (en) | 2012-07-12 | 2014-11-04 | Micron Technologies, Inc. | Methods of forming nano-scale pores, nano-scale electrical contacts, and memory devices including nano-scale electrical contacts, and related structures and devices |
| CN114591337A (zh) * | 2022-03-31 | 2022-06-07 | 武汉工程大学 | 一种吡唑并[1,2-a][1,2,4]三嗪-3,6-二酮衍生物及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047919A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung |
| US20040242660A1 (en) * | 2001-06-20 | 2004-12-02 | Alexander Straub | Substituted oxazolidinones for combinational therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10342570A1 (de) | 2003-09-15 | 2005-04-14 | Bayer Healthcare Ag | Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon |
| US20080051578A1 (en) * | 2006-08-24 | 2008-02-28 | Georg Dahmann | Substituted biaryls, process for their manufacture and use thereof as medicaments |
| WO2008140220A1 (en) * | 2007-05-09 | 2008-11-20 | Legochem Bioscience Ltd. | Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof |
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2008
- 2008-07-03 KR KR1020080064178A patent/KR100898361B1/ko active Active
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2009
- 2009-06-05 JP JP2011516114A patent/JP5325289B2/ja active Active
- 2009-06-05 AU AU2009266631A patent/AU2009266631B2/en active Active
- 2009-06-05 US US13/002,271 patent/US8178525B2/en active Active
- 2009-06-05 WO PCT/KR2009/003008 patent/WO2010002115A2/en not_active Ceased
- 2009-06-05 NZ NZ590315A patent/NZ590315A/xx unknown
- 2009-06-05 BR BRPI0915326A patent/BRPI0915326B8/pt active IP Right Grant
- 2009-06-05 ES ES09773651.6T patent/ES2566755T3/es active Active
- 2009-06-05 MY MYPI2010006218A patent/MY165573A/en unknown
- 2009-06-05 RU RU2011103766/04A patent/RU2468024C2/ru active
- 2009-06-05 CA CA2728350A patent/CA2728350C/en active Active
- 2009-06-05 EP EP09773651.6A patent/EP2307407B1/en active Active
- 2009-06-05 UA UAA201101142A patent/UA97598C2/ru unknown
- 2009-06-05 CN CN200980125825.3A patent/CN102083825B/zh active Active
- 2009-06-05 MX MX2010013969A patent/MX2010013969A/es active IP Right Grant
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2010
- 2010-12-29 CL CL2010001618A patent/CL2010001618A1/es unknown
- 2010-12-30 IL IL210384A patent/IL210384A/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047919A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Substituierte oxazolidinone und ihre verwendung im gebiet der blutgerinnung |
| RU2297415C2 (ru) * | 1999-12-24 | 2007-04-20 | Байер ХельсКер АГ | Замещенные оксазолидиноны, способы их получения, лекарственное средство на их основе и применение замещенных оксазолидинонов |
| US20040242660A1 (en) * | 2001-06-20 | 2004-12-02 | Alexander Straub | Substituted oxazolidinones for combinational therapy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663617C1 (ru) * | 2014-07-18 | 2018-08-07 | Грин Кросс Корпорейшн | Новая кристаллическая форма метансульфонат 5-хлор-n-({ (5s)-2-оксо-3-[4-(5,6-дигидро-4h-[1,2,4]триазин-1-ил)фенил]-1,3-оксазолидин-5-ил} метил)тиофен-2-карбоксамида и содержащая его фармацевтическая композиция |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2307407B1 (en) | 2016-03-16 |
| NZ590315A (en) | 2012-11-30 |
| BRPI0915326A2 (pt) | 2015-08-04 |
| RU2011103766A (ru) | 2012-08-10 |
| CA2728350C (en) | 2013-09-24 |
| WO2010002115A2 (en) | 2010-01-07 |
| BRPI0915326B8 (pt) | 2021-05-25 |
| UA97598C2 (ru) | 2012-02-27 |
| AU2009266631A1 (en) | 2010-01-07 |
| CN102083825B (zh) | 2014-07-30 |
| JP2011526624A (ja) | 2011-10-13 |
| ES2566755T3 (es) | 2016-04-15 |
| AU2009266631B2 (en) | 2012-03-15 |
| CN102083825A (zh) | 2011-06-01 |
| MY165573A (en) | 2018-04-05 |
| CA2728350A1 (en) | 2010-01-07 |
| US8178525B2 (en) | 2012-05-15 |
| US20110112083A1 (en) | 2011-05-12 |
| KR100898361B1 (ko) | 2009-05-20 |
| WO2010002115A3 (en) | 2010-03-11 |
| EP2307407A2 (en) | 2011-04-13 |
| IL210384A (en) | 2014-09-30 |
| CL2010001618A1 (es) | 2011-10-28 |
| IL210384A0 (en) | 2011-03-31 |
| BRPI0915326B1 (pt) | 2021-04-06 |
| JP5325289B2 (ja) | 2013-10-23 |
| EP2307407A4 (en) | 2011-08-24 |
| MX2010013969A (es) | 2011-05-02 |
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