RU2465272C2 - Соединения, моделирующие внутриклеточный кальций - Google Patents

Соединения, моделирующие внутриклеточный кальций Download PDF

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RU2465272C2
RU2465272C2 RU2010112967/04A RU2010112967A RU2465272C2 RU 2465272 C2 RU2465272 C2 RU 2465272C2 RU 2010112967/04 A RU2010112967/04 A RU 2010112967/04A RU 2010112967 A RU2010112967 A RU 2010112967A RU 2465272 C2 RU2465272 C2 RU 2465272C2
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carboxylic acid
thiophene
calcium
chlorophenyl
bromophenyl
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RU2010112967/04A
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English (en)
Russian (ru)
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RU2010112967A (ru
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Гонул ВЕЛИСЕЛЕБИ (US)
Гонул ВЕЛИСЕЛЕБИ
Кеннет А. СТОДЕРМАН (US)
Кеннет А. СТОДЕРМАН
Дэвид П.М. ПЛЕЙНЕТ (US)
Дэвид П.М. ПЛЕЙНЕТ
Соан ЧЕНГ (US)
Соан ЧЕНГ
Джеффри П. УИТТЕН (US)
Джеффри П. УИТТЕН
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КалсиМедика, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
RU2010112967/04A 2007-09-10 2008-08-15 Соединения, моделирующие внутриклеточный кальций RU2465272C2 (ru)

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US97116107P 2007-09-10 2007-09-10
US60/971,161 2007-09-10

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RU2010112967A RU2010112967A (ru) 2011-10-20
RU2465272C2 true RU2465272C2 (ru) 2012-10-27

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US (2) US8263641B2 (enExample)
EP (1) EP2200607A4 (enExample)
JP (1) JP5411141B2 (enExample)
KR (1) KR101257550B1 (enExample)
CN (1) CN101854933A (enExample)
AU (1) AU2008299220B2 (enExample)
BR (1) BRPI0816326A2 (enExample)
CA (1) CA2699157A1 (enExample)
MX (1) MX2010002712A (enExample)
RU (1) RU2465272C2 (enExample)
WO (1) WO2009035818A1 (enExample)

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US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
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JP2013511279A (ja) 2009-11-20 2013-04-04 アムジエン・インコーポレーテツド 抗Ｏｒａｉ１抗原結合蛋白及びその使用
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
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JP5916149B2 (ja) 2010-08-27 2016-05-11 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
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CN102433383B (zh) * 2011-12-19 2015-07-08 上海吉凯基因化学技术有限公司 人stim1基因的用途及其相关药物
EP2844656A1 (en) 2012-05-02 2015-03-11 Lupin Limited Substituted pyrazole compounds as crac modulators
CA2871270A1 (en) 2012-05-02 2013-11-07 Lupin Limited Substituted pyridine compounds as crac modulators
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
US9725463B2 (en) 2013-06-21 2017-08-08 Lupin Limited Substituted heterocyclic compounds as CRAC modulators
EP3013810A1 (en) 2013-06-24 2016-05-04 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
JP6399874B2 (ja) * 2013-09-20 2018-10-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 化合物の抗炎症効果または免疫抑制効果を予測する方法
PT2982982T (pt) * 2014-08-06 2018-01-03 Univ De Bretagne Occidentale U B O Metedo para rastreio de compostos utilizando uma membrana stim1
ES3033759T3 (en) 2015-02-27 2025-08-07 Calcimedica Inc Pancreatitis treatment
DK3331525T3 (da) 2015-08-07 2020-12-14 Calcimedica Inc Anvendelse af CRAC-kanal-inhibitorer til behandling af slagtilfælde og traumatisk hjerneskade
AU2018215089C1 (en) 2017-02-03 2022-09-22 Certa Therapeutics Pty. Ltd. Anti-fibrotic compounds
CN108938625B (zh) * 2017-05-27 2021-06-29 北京大学 2-芳甲酰胺基噻吩-3-羧酸类衍生物作为ano1蛋白抑制剂的用途及制备方法
CN107496420B (zh) * 2017-08-25 2020-07-07 中国科学院微生物研究所 环匹阿尼酸类生物碱化合物的用途
US11840527B2 (en) * 2018-02-08 2023-12-12 Enyo Pharma Non-fused thiophene derivatives and their uses
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CN109081824A (zh) * 2018-10-08 2018-12-25 浙江工业大学上虞研究院有限公司 2-氨基噻吩类化合物的制备方法
CN116444481B (zh) * 2022-01-05 2025-07-25 北京大学 作为ano1蛋白抑制剂的4-芳基噻吩甲酸类化合物
CN114948923A (zh) * 2022-06-02 2022-08-30 南京中医药大学 奥替溴铵及其盐在制备治疗周围神经病变以及肺纤维化药物中的应用

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