RU2457217C2 - Собачий тимусный стромальный лимфопоэтический белок и его применение - Google Patents

Собачий тимусный стромальный лимфопоэтический белок и его применение Download PDF

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RU2457217C2
RU2457217C2 RU2009126617/10A RU2009126617A RU2457217C2 RU 2457217 C2 RU2457217 C2 RU 2457217C2 RU 2009126617/10 A RU2009126617/10 A RU 2009126617/10A RU 2009126617 A RU2009126617 A RU 2009126617A RU 2457217 C2 RU2457217 C2 RU 2457217C2
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tslb
protein
canine
antibodies
amino acid
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RU2009126617/10A
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RU2009126617A (ru
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Джанин Д. МАТТСОН (US)
Джанин Д. МАТТСОН
Даниэль М. ГОРМАН (US)
Даниэль М. ГОРМАН
ВААЛЬ МЕЙЛФИТ Рене ДЕ (US)
ВААЛЬ МЕЙЛФИТ Рене ДЕ
Мохамад А. МОРСИ (US)
Мохамад А. МОРСИ
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Шеринг-Плоу Лтд.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/43—Sweetening agents, e.g. thaumatin, monellin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5418—IL-7
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders
    • G01N2800/202—Dermatitis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
RU2009126617/10A 2006-12-14 2007-12-11 Собачий тимусный стромальный лимфопоэтический белок и его применение RU2457217C2 (ru)

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US87513506P 2006-12-14 2006-12-14
US60/875,135 2006-12-14

Related Child Applications (1)

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RU2012113162A Division RU2617957C2 (ru) 2006-12-14 2012-04-05 Белок слияния, содержащий тимусный стромальный лимфопоэтический белок, вакцина, содержащая экспрессионный вектор для экспрессии белка, и вакцина, содержащая указанный вектор для экспрессии

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RU2009126617A RU2009126617A (ru) 2011-01-20
RU2457217C2 true RU2457217C2 (ru) 2012-07-27

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RU2009126617/10A RU2457217C2 (ru) 2006-12-14 2007-12-11 Собачий тимусный стромальный лимфопоэтический белок и его применение
RU2012113162A RU2617957C2 (ru) 2006-12-14 2012-04-05 Белок слияния, содержащий тимусный стромальный лимфопоэтический белок, вакцина, содержащая экспрессионный вектор для экспрессии белка, и вакцина, содержащая указанный вектор для экспрессии

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RU2012113162A RU2617957C2 (ru) 2006-12-14 2012-04-05 Белок слияния, содержащий тимусный стромальный лимфопоэтический белок, вакцина, содержащая экспрессионный вектор для экспрессии белка, и вакцина, содержащая указанный вектор для экспрессии

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US (3) US7718772B2 (enExample)
EP (1) EP2104683B1 (enExample)
JP (4) JP2010512744A (enExample)
KR (1) KR101525631B1 (enExample)
CN (2) CN102584998B (enExample)
AU (1) AU2007334531B2 (enExample)
BR (1) BRPI0720001A2 (enExample)
CA (1) CA2671865C (enExample)
CO (1) CO6210756A2 (enExample)
ES (1) ES2582655T3 (enExample)
IL (2) IL199170A (enExample)
IN (1) IN2009CN03372A (enExample)
MX (1) MX2009006470A (enExample)
NZ (1) NZ578352A (enExample)
RU (2) RU2457217C2 (enExample)
UA (3) UA120027C2 (enExample)
WO (1) WO2008076255A2 (enExample)
ZA (1) ZA200904152B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2676158C1 (ru) * 2013-12-20 2018-12-26 Интервет Интернэшнл Б.В. Канинизированные мышиные антитела к человеческому pd-1
RU2815059C2 (ru) * 2013-12-20 2024-03-11 Интервет Интернэшнл Б.В. Собачьи антитела с модифицированными последовательностями ch2-ch3

Families Citing this family (15)

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UA120027C2 (uk) 2006-12-14 2019-09-25 Шерінг-Плау Лтд. Ізольоване антитіло проти собачого тимусного стромального лімфопоетину (tslp)
JP5492158B2 (ja) 2011-08-24 2014-05-14 富士フイルム株式会社 ヒトｔｓｈ及び犬ｔｓｈに対する抗体
WO2013119419A1 (en) 2012-02-08 2013-08-15 North Carolina State University Treatment of allergic diseases with recombinant antibodies
AR090915A1 (es) * 2012-05-04 2014-12-17 Intervet Int Bv Proteina de fusion de proteina linfopoyetina estromal timica canina con la region fc de igg
US20160052985A1 (en) * 2013-04-04 2016-02-25 Ieo - Istituto Europeo Di Oncologia Srl Thymic stromal lymphopoietin fragments and uses thereof
MY177098A (en) * 2013-08-09 2020-09-05 Astellas Pharma Inc Novel anti-human tslp receptor antibody
WO2015118124A1 (en) * 2014-02-06 2015-08-13 Vib Vzw Thymic stromal lymphopoietin receptor antagonist
EP3954710A3 (en) 2015-04-02 2022-07-20 Intervet International B.V. Antibodies to canine interleukin-4 receptor alpha
EA038332B1 (ru) 2015-09-09 2021-08-10 Новартис Аг Молекулы, связывающиеся с тимусным стромальным лимфопоэтином (tslp), и способы применения таких молекул
EP3842457A1 (en) 2015-09-09 2021-06-30 Novartis AG Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
ES3014160T3 (en) 2015-12-18 2025-04-21 Intervet Int Bv Caninized human antibodies to human and canine il-4r alpha
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
JP7127859B2 (ja) 2016-11-09 2022-08-30 ノース カロライナ ステート ユニバーシティ キメラタンパク質を用いたアレルギー疾患の治療
WO2019183437A1 (en) 2018-03-23 2019-09-26 North Carolina State University Methods and compositions for antibody to high affinity receptor for ige
CN115028722B (zh) * 2021-03-05 2024-09-03 拜西欧斯（北京）生物技术有限公司 抗tslp抗体及其制备方法和用途

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PREDICTED: similar to thymic stromal lymphopoietin isoform 1 [Canis familiaris]. GenBank, NCBI Reference Sequence: XM_844431.1, 30.08.2005. GenPept, NCBI Reference Sequence: XP_849524.1, 30.08.2005. LIU Y.-J., "Thymic stromal lymphopoietin: master switch for allergic infl animation". The Journal of Experimental Medicine (2006), 203:269-273. RECHE P.A. et al., "Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells", J Immunol (2001), 167:336-343. SOUMELIS V. et al., "Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP", Nature Immunology (2002), 3:673-680. PESCHON J.J. et al., "Early Lymphocyte Expansion Is Severely Impaired in Interleukin 7 Receptor-deficient Mice", J. Exp. Med. (1994), 180:1955-1960. SCHÖN M.P. et al., "The Molecular Basis of Lymphocyte Recruitment to the Skin: Clues for Pathogenesis and Selective Therapies of Inflammatory Disorders", Journal of Investigative Dermatology (2003) 121:951-962. AL-SHAMI A.et *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2676158C1 (ru) * 2013-12-20 2018-12-26 Интервет Интернэшнл Б.В. Канинизированные мышиные антитела к человеческому pd-1
US10711061B2 (en) 2013-12-20 2020-07-14 Intervet Inc. Antibodies against canine PD-1
US10927172B2 (en) 2013-12-20 2021-02-23 Intervet Inc. Caninized murine antibodies to human PD-1
US11680097B2 (en) 2013-12-20 2023-06-20 Intervet Inc. Antibodies against canine PD-1
RU2815059C2 (ru) * 2013-12-20 2024-03-11 Интервет Интернэшнл Б.В. Собачьи антитела с модифицированными последовательностями ch2-ch3
US12252536B2 (en) 2013-12-20 2025-03-18 Intervet Inc. Caninized antibodies

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Publication number Publication date
CN101631800B (zh) 2012-12-05
JP2015107121A (ja) 2015-06-11
CA2671865A1 (en) 2008-06-26
RU2009126617A (ru) 2011-01-20
US8076456B2 (en) 2011-12-13
RU2617957C2 (ru) 2017-04-28
CN101631800A (zh) 2010-01-20
MX2009006470A (es) 2009-06-26
US7718772B2 (en) 2010-05-18
AU2007334531A1 (en) 2008-06-26
KR101525631B1 (ko) 2015-06-04
UA108064C2 (uk) 2015-03-25
US8791242B2 (en) 2014-07-29
IN2009CN03372A (enExample) 2015-08-07
ZA200904152B (en) 2011-11-30
CA2671865C (en) 2017-01-10
CN102584998B (zh) 2017-07-04
WO2008076255A2 (en) 2008-06-26
AU2007334531B2 (en) 2012-04-12
JP5707380B2 (ja) 2015-04-30
JP2013048637A (ja) 2013-03-14
RU2012113162A (ru) 2013-10-20
US20080152620A1 (en) 2008-06-26
UA120027C2 (uk) 2019-09-25
US20130183291A1 (en) 2013-07-18
KR20090097921A (ko) 2009-09-16
WO2008076255A3 (en) 2008-09-18
CO6210756A2 (es) 2010-10-20
UA95329C2 (ru) 2011-07-25
CN102584998A (zh) 2012-07-18
EP2104683A2 (en) 2009-09-30
US20110033478A1 (en) 2011-02-10
JP2010512744A (ja) 2010-04-30
EP2104683B1 (en) 2016-05-25
IL215507A0 (en) 2011-11-30
JP6117767B2 (ja) 2017-04-19
NZ578352A (en) 2012-05-25
ES2582655T3 (es) 2016-09-14
JP2012090647A (ja) 2012-05-17
BRPI0720001A2 (pt) 2013-12-24
IL199170A (en) 2015-04-30

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