RU2435851C2 - Мотивы последовательности рнк в контексте определенных межнуклеотидных связей, индуцирующие специфические иммуномодулирующие профили - Google Patents
Мотивы последовательности рнк в контексте определенных межнуклеотидных связей, индуцирующие специфические иммуномодулирующие профили Download PDFInfo
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- RU2435851C2 RU2435851C2 RU2010104618/10A RU2010104618A RU2435851C2 RU 2435851 C2 RU2435851 C2 RU 2435851C2 RU 2010104618/10 A RU2010104618/10 A RU 2010104618/10A RU 2010104618 A RU2010104618 A RU 2010104618A RU 2435851 C2 RU2435851 C2 RU 2435851C2
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- skeleton
- immunostimulating
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- rna sequence
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- 230000001939 inductive effect Effects 0.000 title claims abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 claims abstract 8
- 229920000642 polymer Polymers 0.000 claims abstract 5
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 4
- 150000004713 phosphodiesters Chemical group 0.000 claims 4
- 108091027075 5S-rRNA precursor Proteins 0.000 claims 3
- 102000006992 Interferon-alpha Human genes 0.000 claims 3
- 108010047761 Interferon-alpha Proteins 0.000 claims 3
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- -1 cationic lipid Chemical class 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 abstract 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 0 *C1**(*)S(*)CC1 Chemical compound *C1**(*)S(*)CC1 0.000 description 1
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96444807P | 2007-08-13 | 2007-08-13 | |
| US60/964,448 | 2007-08-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010104618A RU2010104618A (ru) | 2011-09-20 |
| RU2435851C2 true RU2435851C2 (ru) | 2011-12-10 |
Family
ID=40351228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010104618/10A RU2435851C2 (ru) | 2007-08-13 | 2008-08-08 | Мотивы последовательности рнк в контексте определенных межнуклеотидных связей, индуцирующие специфические иммуномодулирующие профили |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8128944B2 (https=) |
| EP (1) | EP2179039B1 (https=) |
| JP (1) | JP4847609B2 (https=) |
| KR (1) | KR20100045508A (https=) |
| CN (1) | CN101821392B (https=) |
| AR (1) | AR067928A1 (https=) |
| AU (1) | AU2008288241B2 (https=) |
| BR (1) | BRPI0814260B8 (https=) |
| CA (1) | CA2696630C (https=) |
| CL (1) | CL2008002371A1 (https=) |
| CO (1) | CO6260153A2 (https=) |
| DK (1) | DK2179039T3 (https=) |
| ES (1) | ES2703876T3 (https=) |
| MX (1) | MX2010001014A (https=) |
| NZ (1) | NZ582972A (https=) |
| PL (1) | PL2179039T3 (https=) |
| PT (1) | PT2179039T (https=) |
| RU (1) | RU2435851C2 (https=) |
| SI (1) | SI2179039T1 (https=) |
| TR (1) | TR201820474T4 (https=) |
| TW (1) | TW200916106A (https=) |
| WO (1) | WO2009022216A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100045508A (ko) * | 2007-08-13 | 2010-05-03 | 콜리 파마슈티칼 게엠베하 | 특이적 면역 조절 프로필을 유도하는 규정된 뉴클레오티드간 연결의 환경에서의 ｒｎａ 서열 모티프 |
| WO2009027105A2 (en) * | 2007-08-31 | 2009-03-05 | Neurimmune Therapeutics Ag | Method of providing patient specific immune response in amyloidoses and protein aggregation disorders |
| WO2009105641A2 (en) | 2008-02-20 | 2009-08-27 | New York University | Preventing and treating amyloid-beta deposition by stimulation of innate immunity |
| WO2013012875A2 (en) | 2011-07-18 | 2013-01-24 | Mount Sinai School Of Medicine | Bacterial rnas as vaccine adjuvants |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| CR20200260A (es) * | 2017-12-15 | 2020-08-01 | Bayer Animal Health Gmbh | Composiciones inmunoestimulantes |
| WO2024030844A1 (en) * | 2022-08-01 | 2024-02-08 | University Of Mississippi | Choline carboxylic acid based ionic liquids as antimicrobial agents |
Citations (6)
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| RU2127125C1 (ru) * | 1994-03-07 | 1999-03-10 | Дзе Дау Кемикал Компани | Биологически активные и/или целевые дендримерные конъюгаты |
| RU98100213A (ru) * | 1995-06-07 | 1999-11-27 | Супратек Фарма, Инк. | Композиции, включающие биологический агент |
| RU2185818C1 (ru) * | 2001-07-10 | 2002-07-27 | НИИ "Молекулярной медицины" Московской медицинской академии им. И.М. Сеченова | Композиция для лечения легочных инфекций |
| RU2238279C2 (ru) * | 1999-02-15 | 2004-10-20 | Ниппон Синяку Ко., Лтд. | Полинуклеотид с укороченной цепью и способ его получения |
| RU2288921C2 (ru) * | 2000-12-19 | 2006-12-10 | Калифорниа Инститьют оф Текнолоджи | Композиции, содержащие комплексы включения |
| RU2289410C2 (ru) * | 2001-04-04 | 2006-12-20 | Корикса Корпорейшн | Профилактика и лечение инфекционных и других заболеваний с помощью соединений, основанных на моно- и дисахаридах |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5817321A (en) * | 1992-10-08 | 1998-10-06 | Supratek Pharma, Inc. | Biological agent compositions |
| ATE411054T1 (de) | 2001-08-17 | 2008-10-15 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
| EP3006043B1 (en) * | 2002-04-04 | 2019-05-29 | Zoetis Belgium S.A. | Immunostimulatory g,u-containing oligoribonucleotides |
| AU2003236258A1 (en) | 2002-04-12 | 2003-10-27 | Aisin Aw Co., Ltd. | Power supply management system for vehicle mounted apparatus |
| DE10229872A1 (de) * | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
| CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| US20050239733A1 (en) * | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
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| JP4538522B2 (ja) * | 2005-11-25 | 2010-09-08 | コーリー ファーマシューティカル ゲーエムベーハー | 免疫刺激性オリゴリボヌクレオチド |
| KR20100045508A (ko) | 2007-08-13 | 2010-05-03 | 콜리 파마슈티칼 게엠베하 | 특이적 면역 조절 프로필을 유도하는 규정된 뉴클레오티드간 연결의 환경에서의 ｒｎａ 서열 모티프 |
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