JP2020532955A5 - - Google Patents

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Publication number
JP2020532955A5
JP2020532955A5 JP2020506983A JP2020506983A JP2020532955A5 JP 2020532955 A5 JP2020532955 A5 JP 2020532955A5 JP 2020506983 A JP2020506983 A JP 2020506983A JP 2020506983 A JP2020506983 A JP 2020506983A JP 2020532955 A5 JP2020532955 A5 JP 2020532955A5
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JP
Japan
Prior art keywords
nucleic acid
stranded nucleic
chemically modified
acid molecule
modified double
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JP2020506983A
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English (en)
Japanese (ja)
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JP2020532955A (ja
JP7820909B2 (ja
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Priority claimed from PCT/US2018/045671 external-priority patent/WO2019032619A1/en
Publication of JP2020532955A publication Critical patent/JP2020532955A/ja
Publication of JP2020532955A5 publication Critical patent/JP2020532955A5/ja
Priority to JP2023146785A priority Critical patent/JP2024028231A/ja
Application granted granted Critical
Publication of JP7820909B2 publication Critical patent/JP7820909B2/ja
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JP2020506983A 2017-08-07 2018-08-07 化学修飾されたオリゴヌクレオチド Active JP7820909B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023146785A JP2024028231A (ja) 2017-08-07 2023-09-11 化学修飾されたオリゴヌクレオチド

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762542043P 2017-08-07 2017-08-07
US62/542,043 2017-08-07
US201762558183P 2017-09-13 2017-09-13
US62/558,183 2017-09-13
PCT/US2018/045671 WO2019032619A1 (en) 2017-08-07 2018-08-07 CHEMICALLY MODIFIED OLIGONUCLEOTIDES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023146785A Division JP2024028231A (ja) 2017-08-07 2023-09-11 化学修飾されたオリゴヌクレオチド

Publications (3)

Publication Number Publication Date
JP2020532955A JP2020532955A (ja) 2020-11-19
JP2020532955A5 true JP2020532955A5 (https=) 2021-08-26
JP7820909B2 JP7820909B2 (ja) 2026-02-26

Family

ID=65271710

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020506983A Active JP7820909B2 (ja) 2017-08-07 2018-08-07 化学修飾されたオリゴヌクレオチド
JP2023146785A Pending JP2024028231A (ja) 2017-08-07 2023-09-11 化学修飾されたオリゴヌクレオチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023146785A Pending JP2024028231A (ja) 2017-08-07 2023-09-11 化学修飾されたオリゴヌクレオチド

Country Status (7)

Country Link
US (1) US20200215113A1 (https=)
EP (1) EP3664817A4 (https=)
JP (2) JP7820909B2 (https=)
CN (1) CN111201024A (https=)
AU (1) AU2018313149B2 (https=)
CA (1) CA3070747A1 (https=)
WO (1) WO2019032619A1 (https=)

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CA2746527A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
CN106074591B (zh) 2010-03-24 2020-01-14 菲奥医药公司 眼部症候中的rna干扰
US9080171B2 (en) 2010-03-24 2015-07-14 RXi Parmaceuticals Corporation Reduced size self-delivering RNAi compounds
WO2015084897A2 (en) * 2013-12-02 2015-06-11 Mirimmune, Llc Immunotherapy of cancer
US11279934B2 (en) 2014-04-28 2022-03-22 Phio Pharmaceuticals Corp. Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
KR102506169B1 (ko) 2014-09-05 2023-03-08 피오 파마슈티칼스 코프. Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
CN108135923B (zh) 2015-07-06 2021-03-02 菲奥医药公司 靶向超氧化物歧化酶1（sod1）的核酸分子
WO2017070151A1 (en) 2015-10-19 2017-04-27 Rxi Pharmaceuticals Corporation Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
WO2018195355A1 (en) 2017-04-19 2018-10-25 Rxi Pharmaceuticals Corporation Topical delivery of nucleic acid compounds
CN115135765A (zh) * 2019-11-08 2022-09-30 菲奥医药公司 用于免疫治疗的靶向含布罗莫结构域之蛋白4(brd4)的经化学修饰的寡核苷酸
CN115916348A (zh) 2020-06-18 2023-04-04 基因泰克公司 使用抗tigit抗体和pd-1轴结合拮抗剂的治疗
CN112266911B (zh) * 2020-08-27 2022-07-22 清华大学 核酸分子
CN118871463A (zh) 2021-07-28 2024-10-29 基因泰克公司 用于治疗癌症的方法和组合物
WO2023015264A1 (en) * 2021-08-04 2023-02-09 Phio Pharmaceuticals Corp. Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides
JP2024529025A (ja) 2021-08-04 2024-08-01 フィオ ファーマシューティカルズ コーポレーション 化学修飾されたオリゴヌクレオチド
TW202321308A (zh) 2021-09-30 2023-06-01 美商建南德克公司 使用抗ｔｉｇｉｔ抗體、抗ｃｄ３８抗體及ｐｄ—１軸結合拮抗劑治療血液癌症的方法
WO2023130021A1 (en) * 2021-12-30 2023-07-06 Phio Pharmaceuticals Corp. Chemically modified oligonucleotides with improved delivery properties
EP4537107A2 (en) 2022-06-07 2025-04-16 Genentech, Inc. Method for determining the efficacy of a lung cancer treatment comprising an anti-pd-l1 antagonist and an anti-tigit antagonist antibody
WO2024064769A1 (en) * 2022-09-21 2024-03-28 Phio Pharmaceuticals Corp. Induction of stem-like activated t cells
WO2025101204A1 (en) * 2023-11-08 2025-05-15 Phio Pharmaceuticals Corp. Intratumoral targeting of pd-1
WO2025117786A1 (en) * 2023-11-28 2025-06-05 Phio Pharmaceuticals Corp. Enhanced combination immune checkpoint inhibition therapy utilizing rnai

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
CA2746527A1 (en) * 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
US8691971B2 (en) * 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
US9745574B2 (en) * 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US9957558B2 (en) * 2011-04-28 2018-05-01 Life Technologies Corporation Methods and compositions for multiplex PCR
WO2015084897A2 (en) * 2013-12-02 2015-06-11 Mirimmune, Llc Immunotherapy of cancer
CA2958200A1 (en) * 2014-08-14 2016-02-18 Novartis Ag Treatment of cancer using a gfr alpha-4 chimeric antigen receptor
WO2016177343A1 (zh) * 2015-05-05 2016-11-10 江苏命码生物科技有限公司 一种新的前体miRNA及其在肿瘤治疗中的应用
EP3349792A1 (en) * 2015-09-14 2018-07-25 Compass Therapeutics LLC Compositions and methods for treating cancer via antagonism of the cd155/tigit pathway and tgf-

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