CL2008002371A1 - Composicion que comprende un polimero de hebra simple con un motivo arn inmunoestimulante; metodo que comprende poner en contacto una celula inmune capaz de producir interferon alfa con dicho polimero; y metodos para tratar el asma, una condicion alergica, el cancer y una enfermedad infecciosa. - Google Patents

Composicion que comprende un polimero de hebra simple con un motivo arn inmunoestimulante; metodo que comprende poner en contacto una celula inmune capaz de producir interferon alfa con dicho polimero; y metodos para tratar el asma, una condicion alergica, el cancer y una enfermedad infecciosa.

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Publication number
CL2008002371A1
CL2008002371A1 CL2008002371A CL2008002371A CL2008002371A1 CL 2008002371 A1 CL2008002371 A1 CL 2008002371A1 CL 2008002371 A CL2008002371 A CL 2008002371A CL 2008002371 A CL2008002371 A CL 2008002371A CL 2008002371 A1 CL2008002371 A1 CL 2008002371A1
Authority
CL
Chile
Prior art keywords
polymer
cancer
contacting
composition
methods
Prior art date
Application number
CL2008002371A
Other languages
English (en)
Inventor
Jurk Mario
Heinz Vollmer Jorg
Original Assignee
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40351228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008002371(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coley Pharm Gmbh filed Critical Coley Pharm Gmbh
Publication of CL2008002371A1 publication Critical patent/CL2008002371A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

Composición que comprende un polímero de hebra simple con un motivo ARN inmunoestimulante; método que comprende poner en contacto una célula inmune capaz de producir interferón alfa con dicho polímero; métodos para tratar el asma, una condición alérgica, el cáncer y una enfermedad infecciosa.
CL2008002371A 2007-08-13 2008-08-12 Composicion que comprende un polimero de hebra simple con un motivo arn inmunoestimulante; metodo que comprende poner en contacto una celula inmune capaz de producir interferon alfa con dicho polimero; y metodos para tratar el asma, una condicion alergica, el cancer y una enfermedad infecciosa. CL2008002371A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96444807P 2007-08-13 2007-08-13

Publications (1)

Publication Number Publication Date
CL2008002371A1 true CL2008002371A1 (es) 2009-07-03

Family

ID=40351228

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002371A CL2008002371A1 (es) 2007-08-13 2008-08-12 Composicion que comprende un polimero de hebra simple con un motivo arn inmunoestimulante; metodo que comprende poner en contacto una celula inmune capaz de producir interferon alfa con dicho polimero; y metodos para tratar el asma, una condicion alergica, el cancer y una enfermedad infecciosa.

Country Status (23)

Country Link
US (3) US8128944B2 (es)
EP (1) EP2179039B1 (es)
JP (1) JP4847609B2 (es)
KR (1) KR20100045508A (es)
CN (1) CN101821392B (es)
AR (1) AR067928A1 (es)
AU (1) AU2008288241B2 (es)
BR (1) BRPI0814260B8 (es)
CA (1) CA2696630C (es)
CL (1) CL2008002371A1 (es)
CO (1) CO6260153A2 (es)
DK (1) DK2179039T3 (es)
ES (1) ES2703876T3 (es)
HK (1) HK1143741A1 (es)
MX (1) MX2010001014A (es)
NZ (1) NZ582972A (es)
PL (1) PL2179039T3 (es)
PT (1) PT2179039T (es)
RU (1) RU2435851C2 (es)
SI (1) SI2179039T1 (es)
TR (1) TR201820474T4 (es)
TW (1) TW200916106A (es)
WO (1) WO2009022216A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101821392B (zh) * 2007-08-13 2013-04-17 科勒制药有限责任公司 在限定核苷酸间键环境下的诱导特异性免疫调节特性的rna序列基序
EP2185160B1 (en) * 2007-08-31 2019-02-13 Neurimmune Holding AG Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
US10383887B2 (en) 2008-02-20 2019-08-20 New York University Preventing and treating amyloid-beta deposition by stimulation of innate immunity
WO2013012875A2 (en) 2011-07-18 2013-01-24 Mount Sinai School Of Medicine Bacterial rnas as vaccine adjuvants
EP3508198A1 (en) 2014-06-04 2019-07-10 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
AU2015349680A1 (en) 2014-11-21 2017-06-08 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
JP7458977B2 (ja) * 2017-12-15 2024-04-01 エランコ アニマル ヘルス ゲー・エム・ベー・ハー 免疫刺激性組成物
WO2024030844A1 (en) * 2022-08-01 2024-02-08 University Of Mississippi Choline carboxylic acid based ionic liquids as antimicrobial agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160157A0 (en) 2001-08-17 2004-07-25 Coley Pharm Group Inc Combination motif immune stimulation oligonucleotides with improved activity
ES2734652T3 (es) 2002-04-04 2019-12-11 Zoetis Belgium S A Oligorribonucleótidos inmunoestimulantes que contienen G y U
WO2003086820A1 (en) 2002-04-12 2003-10-23 Aisin Aw Co., Ltd. Power supply management system for vehicle mounted apparatus
DE10229872A1 (de) * 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
WO2004053104A2 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
WO2005009355A2 (en) * 2003-07-15 2005-02-03 Hybridon, Inc. Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy
US20050239733A1 (en) 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
WO2005097993A2 (en) * 2004-02-19 2005-10-20 Coley Pharmaceutical Group, Inc. Immunostimulatory viral rna oligonucleotides
MY159370A (en) * 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
US8076068B2 (en) * 2005-09-14 2011-12-13 Gunther Hartmann Method for determining immunostimulatory activity of RNA oligonucleotides
PT1957647E (pt) * 2005-11-25 2015-06-01 Zoetis Belgium S A Oligorribonucleótidos imunoestimulantes
CN101821392B (zh) * 2007-08-13 2013-04-17 科勒制药有限责任公司 在限定核苷酸间键环境下的诱导特异性免疫调节特性的rna序列基序

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CA2696630C (en) 2014-04-01
JP2010536739A (ja) 2010-12-02
BRPI0814260B1 (pt) 2019-11-12
US20120258140A1 (en) 2012-10-11
US20120121648A1 (en) 2012-05-17
CN101821392B (zh) 2013-04-17
PL2179039T3 (pl) 2019-03-29
ES2703876T3 (es) 2019-03-12
AU2008288241B2 (en) 2011-12-01
WO2009022216A9 (en) 2009-04-30
NZ582972A (en) 2011-09-30
DK2179039T3 (en) 2019-01-07
BRPI0814260B8 (pt) 2021-05-25
CA2696630A1 (en) 2009-02-19
WO2009022216A2 (en) 2009-02-19
SI2179039T1 (sl) 2019-01-31
KR20100045508A (ko) 2010-05-03
EP2179039B1 (en) 2018-10-31
US8128944B2 (en) 2012-03-06
TW200916106A (en) 2009-04-16
CO6260153A2 (es) 2011-03-22
CN101821392A (zh) 2010-09-01
AR067928A1 (es) 2009-10-28
EP2179039A2 (en) 2010-04-28
JP4847609B2 (ja) 2011-12-28
US8227447B2 (en) 2012-07-24
WO2009022216A3 (en) 2009-06-04
PT2179039T (pt) 2019-01-11
RU2010104618A (ru) 2011-09-20
TR201820474T4 (tr) 2019-01-21
HK1143741A1 (en) 2011-01-14
US20100272785A1 (en) 2010-10-28
BRPI0814260A2 (pt) 2015-03-31
US8466124B2 (en) 2013-06-18
MX2010001014A (es) 2010-03-01
RU2435851C2 (ru) 2011-12-10
AU2008288241A1 (en) 2009-02-19

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