WO2003057822A3 - Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends - Google Patents

Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends Download PDF

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Publication number
WO2003057822A3
WO2003057822A3 PCT/US2002/034247 US0234247W WO03057822A3 WO 2003057822 A3 WO2003057822 A3 WO 2003057822A3 US 0234247 W US0234247 W US 0234247W WO 03057822 A3 WO03057822 A3 WO 03057822A3
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WIPO (PCT)
Prior art keywords
oligonucleotide
modulation
based compounds
oligonucleotides
immunostimulatory properties
Prior art date
Application number
PCT/US2002/034247
Other languages
French (fr)
Other versions
WO2003057822A2 (en
WO2003057822A9 (en
Inventor
Sudhir Agrawal
Ekambar M Kandimalla
Dong Yu
Lakshmi Bhagat
Original Assignee
Hybridon Inc
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Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Priority to AU2002365141A priority Critical patent/AU2002365141C1/en
Priority to KR1020047006160A priority patent/KR100945104B1/en
Priority to JP2003558124A priority patent/JP5005878B2/en
Priority to CA2463798A priority patent/CA2463798C/en
Publication of WO2003057822A2 publication Critical patent/WO2003057822A2/en
Publication of WO2003057822A3 publication Critical patent/WO2003057822A3/en
Publication of WO2003057822A9 publication Critical patent/WO2003057822A9/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/33—Chemical structure of the base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/52—Physical structure branched

Abstract

The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.
PCT/US2002/034247 2001-10-24 2002-10-24 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends WO2003057822A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002365141A AU2002365141C1 (en) 2001-10-24 2002-10-24 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
KR1020047006160A KR100945104B1 (en) 2001-10-24 2002-10-24 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
JP2003558124A JP5005878B2 (en) 2001-10-24 2002-10-24 Regulation of immunostimulation of oligonucleotide compounds by optimal display of the 5 'end
CA2463798A CA2463798C (en) 2001-10-24 2002-10-24 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34476701P 2001-10-24 2001-10-24
US60/344,767 2001-10-24

Publications (3)

Publication Number Publication Date
WO2003057822A2 WO2003057822A2 (en) 2003-07-17
WO2003057822A3 true WO2003057822A3 (en) 2004-02-26
WO2003057822A9 WO2003057822A9 (en) 2004-07-01

Family

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PCT/US2002/033756 WO2003035836A2 (en) 2001-10-24 2002-10-22 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
PCT/US2002/034247 WO2003057822A2 (en) 2001-10-24 2002-10-24 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033756 WO2003035836A2 (en) 2001-10-24 2002-10-22 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends

Country Status (5)

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JP (1) JP5005878B2 (en)
KR (1) KR100945104B1 (en)
AU (1) AU2002365141C1 (en)
CA (1) CA2463798C (en)
WO (2) WO2003035836A2 (en)

Cited By (3)

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US7723500B2 (en) 1994-07-15 2010-05-25 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US8188254B2 (en) 2003-10-30 2012-05-29 Coley Pharmaceutical Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
US9028845B2 (en) 2001-06-21 2015-05-12 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same-IV

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