RU2431632C2 - Производные хиназолина - Google Patents

Производные хиназолина Download PDF

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Publication number
RU2431632C2
RU2431632C2 RU2008137654/04A RU2008137654A RU2431632C2 RU 2431632 C2 RU2431632 C2 RU 2431632C2 RU 2008137654/04 A RU2008137654/04 A RU 2008137654/04A RU 2008137654 A RU2008137654 A RU 2008137654A RU 2431632 C2 RU2431632 C2 RU 2431632C2
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RU
Russia
Prior art keywords
compound
dimethoxy
methylaminoquinazolin
phenyl
acceptable salt
Prior art date
Application number
RU2008137654/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2008137654A (ru
Inventor
Казуки МИЯЗАКИ (JP)
Казуки МИЯЗАКИ
Казутоми КУСАНО (JP)
Казутоми КУСАНО
Ясутака ТАКАСЕ (JP)
Ясутака ТАКАСЕ
Осаму АСАНО (JP)
Осаму АСАНО
Манабу СИРАТО (JP)
Манабу СИРАТО
Хисаси ВАКИТА (JP)
Хисаси ВАКИТА
Наото ИСИИ (JP)
Наото ИСИИ
Такао САЕКИ (JP)
Такао САЕКИ
Original Assignee
Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйсай Ар Энд Ди Менеджмент Ко., Лтд. filed Critical Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Publication of RU2008137654A publication Critical patent/RU2008137654A/ru
Application granted granted Critical
Publication of RU2431632C2 publication Critical patent/RU2431632C2/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2008137654/04A 2006-02-21 2007-02-20 Производные хиназолина RU2431632C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-043273 2006-02-21
JP2006043273 2006-02-21
JP20096-043273 2006-02-21

Publications (2)

Publication Number Publication Date
RU2008137654A RU2008137654A (ru) 2010-03-27
RU2431632C2 true RU2431632C2 (ru) 2011-10-20

Family

ID=42137992

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008137654/04A RU2431632C2 (ru) 2006-02-21 2007-02-20 Производные хиназолина

Country Status (18)

Country Link
JP (1) JP4778550B2 (ko)
KR (1) KR101278852B1 (ko)
AT (1) ATE517875T1 (ko)
BR (1) BRPI0708098B8 (ko)
CY (1) CY1112554T1 (ko)
DK (1) DK1992622T3 (ko)
ES (1) ES2368089T3 (ko)
HK (1) HK1122025A1 (ko)
HR (1) HRP20110604T1 (ko)
IL (1) IL193322A (ko)
JO (1) JO2726B1 (ko)
MY (1) MY146275A (ko)
NZ (1) NZ569936A (ko)
PT (1) PT1992622E (ko)
RS (1) RS51969B (ko)
RU (1) RU2431632C2 (ko)
SI (1) SI1992622T1 (ko)
TW (1) TWI404709B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123641A4 (en) 2007-02-16 2011-06-22 Eisai R&D Man Co Ltd CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
AU2008290000B2 (en) 2007-08-17 2012-05-10 Eisai R & D Management Co., Ltd. Method for producing quinazoline derivative
TWI414296B (zh) 2007-08-17 2013-11-11 Eisai R&D Man Co Ltd Innovative agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
JPH11209350A (ja) 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HANIFIN J.M. et al. «Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Antiinflammatory Effects in Atopic Dermatites» Journal of Investigative Dermotology, 1996, v.106, no.1, p.51-56. SCHMIDT B.M.W. et al. «The Phosphodiesterase 4 Inhibitors rofluumilast is effective in the treatment of allergic rhinitis», Journal of Allergy and Clinical Immunology, 2001, v.21, no.4, 530-536. *

Also Published As

Publication number Publication date
HK1122025A1 (ko) 2009-05-08
JO2726B1 (en) 2013-09-15
NZ569936A (en) 2010-07-30
MY146275A (en) 2012-07-31
BRPI0708098B8 (pt) 2021-05-25
ES2368089T3 (es) 2011-11-14
KR101278852B1 (ko) 2013-07-01
TW200812980A (en) 2008-03-16
SI1992622T1 (sl) 2011-11-30
PT1992622E (pt) 2011-09-19
JP4778550B2 (ja) 2011-09-21
IL193322A (en) 2014-04-30
TWI404709B (zh) 2013-08-11
CY1112554T1 (el) 2016-02-10
DK1992622T3 (da) 2011-09-05
KR20080094811A (ko) 2008-10-24
BRPI0708098A2 (pt) 2011-05-17
BRPI0708098B1 (pt) 2019-08-06
RS51969B (en) 2012-02-29
JPWO2007097317A1 (ja) 2009-07-16
HRP20110604T1 (hr) 2011-09-30
RU2008137654A (ru) 2010-03-27
ATE517875T1 (de) 2011-08-15
IL193322A0 (en) 2009-05-04

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