RU2426542C2 - Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении - Google Patents

Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении Download PDF

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Publication number
RU2426542C2
RU2426542C2 RU2008151713/15A RU2008151713A RU2426542C2 RU 2426542 C2 RU2426542 C2 RU 2426542C2 RU 2008151713/15 A RU2008151713/15 A RU 2008151713/15A RU 2008151713 A RU2008151713 A RU 2008151713A RU 2426542 C2 RU2426542 C2 RU 2426542C2
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RU
Russia
Prior art keywords
amino
dione
pharmaceutically acceptable
acceptable salt
effective amount
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RU2008151713/15A
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English (en)
Russian (ru)
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RU2008151713A (ru
Inventor
Доминик ВЕРЕЛЛЬ (US)
Доминик ВЕРЕЛЛЬ
Кайл ЧАНЬ (US)
Кайл ЧАНЬ
Лора КОРРАЛ (US)
Лора КОРРАЛ
ДЕ ПАРСЕВАЛЬ Лор МУТУ (US)
ДЕ ПАРСЕВАЛЬ Лор МУТУ
Хелен БРЭДИ (US)
Хелен БРЭДИ
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Селджин Корпорейшн
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Publication of RU2008151713A publication Critical patent/RU2008151713A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2008151713/15A 2006-05-26 2007-05-24 Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении RU2426542C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80860206P 2006-05-26 2006-05-26
US60/808,602 2006-05-26

Publications (2)

Publication Number Publication Date
RU2008151713A RU2008151713A (ru) 2010-07-10
RU2426542C2 true RU2426542C2 (ru) 2011-08-20

Family

ID=38606531

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008151713/15A RU2426542C2 (ru) 2006-05-26 2007-05-24 Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении

Country Status (11)

Country Link
EP (1) EP2023912A2 (es)
JP (1) JP2009538318A (es)
KR (1) KR20090014393A (es)
CN (1) CN101495111A (es)
AU (1) AU2007267928A1 (es)
CA (1) CA2652888A1 (es)
IL (1) IL195412A0 (es)
MX (1) MX2008014912A (es)
RU (1) RU2426542C2 (es)
WO (1) WO2007139939A2 (es)
ZA (1) ZA200809956B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2249835A1 (en) * 2008-01-29 2010-11-17 Celgene Corporation Methods using immunomodulatory compounds for modulating level of cd59
US20150087687A1 (en) * 2012-03-23 2015-03-26 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
EA037638B1 (ru) * 2013-08-22 2021-04-23 Ванда Фармасьютикалз Инк. Лечение множественной миеломы
US20160199323A1 (en) 2013-08-22 2016-07-14 Vanda Pharmaceuticals, Inc. Cancer treatment
JP2017511132A (ja) * 2014-03-26 2017-04-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法
WO2015175916A1 (en) * 2014-05-16 2015-11-19 Celgene Corporation Methods and compositions using 4-amino-2-(2,6 dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment of cancers
WO2023034504A1 (en) * 2021-09-01 2023-03-09 Flagship Pioneering Innovations Vi, Llc Methods and compositions for inducing fetal hemoglobin, modulating erythroid cell lineages, and perturbing megakaryocyte lineages

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
NZ572388A (en) * 2002-05-17 2010-05-28 Celgene Corp Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
KR20050057672A (ko) * 2002-10-24 2005-06-16 셀진 코포레이션 통증의 치료, 변형 및 관리를 위한 면역조절 화합물을포함하는 조성물 및 이의 사용 방법
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US20050143420A1 (en) * 2003-12-02 2005-06-30 Moutouh-De Parseval Laure Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation

Also Published As

Publication number Publication date
JP2009538318A (ja) 2009-11-05
MX2008014912A (es) 2008-12-10
EP2023912A2 (en) 2009-02-18
ZA200809956B (en) 2010-07-28
CN101495111A (zh) 2009-07-29
KR20090014393A (ko) 2009-02-10
AU2007267928A1 (en) 2007-12-06
RU2008151713A (ru) 2010-07-10
WO2007139939A2 (en) 2007-12-06
IL195412A0 (en) 2009-08-03
CA2652888A1 (en) 2007-12-06
WO2007139939A3 (en) 2008-07-03

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Effective date: 20120525