JP2009538318A - 併用療法において免疫調節化合物を用いる方法及び組成物 - Google Patents
併用療法において免疫調節化合物を用いる方法及び組成物 Download PDFInfo
- Publication number
- JP2009538318A JP2009538318A JP2009512164A JP2009512164A JP2009538318A JP 2009538318 A JP2009538318 A JP 2009538318A JP 2009512164 A JP2009512164 A JP 2009512164A JP 2009512164 A JP2009512164 A JP 2009512164A JP 2009538318 A JP2009538318 A JP 2009538318A
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- Prior art keywords
- amino
- dione
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- acceptable salt
- effective amount
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- 0 CC(*)C1CC(C)CC1 Chemical compound CC(*)C1CC(C)CC1 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80860206P | 2006-05-26 | 2006-05-26 | |
PCT/US2007/012495 WO2007139939A2 (en) | 2006-05-26 | 2007-05-24 | Methods and compositions using immunomodulatory compounds in combination therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009538318A true JP2009538318A (ja) | 2009-11-05 |
JP2009538318A5 JP2009538318A5 (es) | 2010-07-29 |
Family
ID=38606531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009512164A Pending JP2009538318A (ja) | 2006-05-26 | 2007-05-24 | 併用療法において免疫調節化合物を用いる方法及び組成物 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2023912A2 (es) |
JP (1) | JP2009538318A (es) |
KR (1) | KR20090014393A (es) |
CN (1) | CN101495111A (es) |
AU (1) | AU2007267928A1 (es) |
CA (1) | CA2652888A1 (es) |
IL (1) | IL195412A0 (es) |
MX (1) | MX2008014912A (es) |
RU (1) | RU2426542C2 (es) |
WO (1) | WO2007139939A2 (es) |
ZA (1) | ZA200809956B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017511132A (ja) * | 2014-03-26 | 2017-04-20 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | ヒト造血幹/前駆細胞のエクスビボ拡大のための組成物および方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011510983A (ja) | 2008-01-29 | 2011-04-07 | セルジーン コーポレイション | Cd59のレベルを調節するための、免疫調節化合物を使用する方法 |
EP2827869A4 (en) * | 2012-03-23 | 2015-09-23 | Dennis Brown | COMPOSITIONS AND METHODS FOR IMPROVING THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ITS ANALOGUES INCLUDING MESOINDIGO |
CN105579101A (zh) | 2013-08-22 | 2016-05-11 | 万达制药公司 | 癌症的治疗 |
MX2016002308A (es) | 2013-08-22 | 2016-06-15 | Vanda Pharmaceuticals Inc | Tratamiento del mieloma multiple. |
WO2015175916A1 (en) * | 2014-05-16 | 2015-11-19 | Celgene Corporation | Methods and compositions using 4-amino-2-(2,6 dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment of cancers |
WO2023034504A1 (en) * | 2021-09-01 | 2023-03-09 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for inducing fetal hemoglobin, modulating erythroid cell lineages, and perturbing megakaryocyte lineages |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08507767A (ja) * | 1993-03-01 | 1996-08-20 | ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン | 管脈形成を抑制する方法および組成物 |
JP2005530784A (ja) * | 2002-05-17 | 2005-10-13 | セルジーン・コーポレーション | 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物 |
JP2006500911A (ja) * | 2002-04-12 | 2006-01-12 | セルジーン・コーポレーション | 幹細胞及び前駆細胞の分化のモジュレーション、アッセイ、並びにそれらの使用 |
JP2006507284A (ja) * | 2002-10-24 | 2006-03-02 | セルジーン・コーポレーション | 疼痛を治療、改変および管理するための免疫調節化合物の使用方法および組成物 |
JP2006507325A (ja) * | 2002-11-06 | 2006-03-02 | セルジーン・コーポレーション | 骨髄増殖性疾患の治療および管理のための免疫調節化合物を含む使用方法および組成物 |
JP2007513164A (ja) * | 2003-12-02 | 2007-05-24 | セルジーン・コーポレーション | 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
-
2007
- 2007-05-24 ZA ZA200809956A patent/ZA200809956B/xx unknown
- 2007-05-24 JP JP2009512164A patent/JP2009538318A/ja active Pending
- 2007-05-24 KR KR1020087031357A patent/KR20090014393A/ko not_active Application Discontinuation
- 2007-05-24 RU RU2008151713/15A patent/RU2426542C2/ru not_active IP Right Cessation
- 2007-05-24 WO PCT/US2007/012495 patent/WO2007139939A2/en active Application Filing
- 2007-05-24 AU AU2007267928A patent/AU2007267928A1/en not_active Abandoned
- 2007-05-24 CN CNA2007800277224A patent/CN101495111A/zh active Pending
- 2007-05-24 CA CA002652888A patent/CA2652888A1/en not_active Abandoned
- 2007-05-24 MX MX2008014912A patent/MX2008014912A/es not_active Application Discontinuation
- 2007-05-24 EP EP07795353A patent/EP2023912A2/en not_active Withdrawn
-
2008
- 2008-11-20 IL IL195412A patent/IL195412A0/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08507767A (ja) * | 1993-03-01 | 1996-08-20 | ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン | 管脈形成を抑制する方法および組成物 |
JP2006500911A (ja) * | 2002-04-12 | 2006-01-12 | セルジーン・コーポレーション | 幹細胞及び前駆細胞の分化のモジュレーション、アッセイ、並びにそれらの使用 |
JP2005530784A (ja) * | 2002-05-17 | 2005-10-13 | セルジーン・コーポレーション | 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物 |
JP2006507284A (ja) * | 2002-10-24 | 2006-03-02 | セルジーン・コーポレーション | 疼痛を治療、改変および管理するための免疫調節化合物の使用方法および組成物 |
JP2006507325A (ja) * | 2002-11-06 | 2006-03-02 | セルジーン・コーポレーション | 骨髄増殖性疾患の治療および管理のための免疫調節化合物を含む使用方法および組成物 |
JP2007513164A (ja) * | 2003-12-02 | 2007-05-24 | セルジーン・コーポレーション | 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物 |
Non-Patent Citations (4)
Title |
---|
JPN6012054646; GORE,S.D.: 'Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies' Nat Clin Pract Oncol Vol.2 Suppl 1, 2005, p.S30-5 * |
JPN6012054647; MARIANNA,P. et al: 'Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gen' Haematologica Vol.86, No.7, 2001, p.700-5 * |
JPN6012054650; DE,F.E. et al: 'Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematop' Cancer Res Vol.65, No.4, 2005, p.1505-13 * |
JPN6012054651; BUG,G. et al: 'Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells' Cancer Res Vol.65, No.7, 2005, p.2537-41 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017511132A (ja) * | 2014-03-26 | 2017-04-20 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | ヒト造血幹/前駆細胞のエクスビボ拡大のための組成物および方法 |
JP2020124212A (ja) * | 2014-03-26 | 2020-08-20 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | ヒト造血幹/前駆細胞のエクスビボ拡大のための組成物および方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2007139939A2 (en) | 2007-12-06 |
MX2008014912A (es) | 2008-12-10 |
RU2008151713A (ru) | 2010-07-10 |
CA2652888A1 (en) | 2007-12-06 |
CN101495111A (zh) | 2009-07-29 |
IL195412A0 (en) | 2009-08-03 |
EP2023912A2 (en) | 2009-02-18 |
RU2426542C2 (ru) | 2011-08-20 |
ZA200809956B (en) | 2010-07-28 |
WO2007139939A3 (en) | 2008-07-03 |
KR20090014393A (ko) | 2009-02-10 |
AU2007267928A1 (en) | 2007-12-06 |
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