RU2425876C2 - Способ модулирования роста гематопоэтических стволовых клеток - Google Patents
Способ модулирования роста гематопоэтических стволовых клеток Download PDFInfo
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- RU2425876C2 RU2425876C2 RU2008142106A RU2008142106A RU2425876C2 RU 2425876 C2 RU2425876 C2 RU 2425876C2 RU 2008142106 A RU2008142106 A RU 2008142106A RU 2008142106 A RU2008142106 A RU 2008142106A RU 2425876 C2 RU2425876 C2 RU 2425876C2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78596806P | 2006-03-24 | 2006-03-24 | |
US60/785,968 | 2006-03-24 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011115827/10A Division RU2493252C2 (ru) | 2006-03-24 | 2007-03-26 | Способ стимулирования экспансии гематопоэтических стволовых клеток |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2008142106A RU2008142106A (ru) | 2010-04-27 |
RU2425876C2 true RU2425876C2 (ru) | 2011-08-10 |
Family
ID=38526581
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008142106A RU2425876C2 (ru) | 2006-03-24 | 2007-03-26 | Способ модулирования роста гематопоэтических стволовых клеток |
RU2011115827/10A RU2493252C2 (ru) | 2006-03-24 | 2007-03-26 | Способ стимулирования экспансии гематопоэтических стволовых клеток |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011115827/10A RU2493252C2 (ru) | 2006-03-24 | 2007-03-26 | Способ стимулирования экспансии гематопоэтических стволовых клеток |
Country Status (11)
Country | Link |
---|---|
US (7) | US8168428B2 (fr) |
EP (3) | EP3424507A1 (fr) |
JP (8) | JP5247675B2 (fr) |
CN (2) | CN102626517B (fr) |
AU (1) | AU2007230902B2 (fr) |
CA (1) | CA2647201C (fr) |
HK (1) | HK1173948A1 (fr) |
MX (2) | MX2008012178A (fr) |
RU (2) | RU2425876C2 (fr) |
WO (1) | WO2007112084A2 (fr) |
ZA (2) | ZA200808123B (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10751373B2 (en) | 2015-07-21 | 2020-08-25 | The Children's Medical Center Corporation | PD-L1 expressing hematopoietic stem cells and uses |
US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
Families Citing this family (56)
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EP3424507A1 (fr) | 2006-03-24 | 2019-01-09 | Children's Medical Center Corporation | Procédé de modulation de croissance de cellules souches hématopoïétiques |
JP5426389B2 (ja) | 2006-10-20 | 2014-02-26 | チルドレンズ メディカル センター コーポレーション | 組織の再生を亢進するための方法 |
US9394520B2 (en) | 2006-12-08 | 2016-07-19 | University Of Rochester | Expansion of hematopoietic stem cells |
US8263403B2 (en) * | 2007-04-23 | 2012-09-11 | Stowers Institute For Medical Research | Methods and compositions for stem cell self-renewal |
US8871752B2 (en) * | 2008-02-19 | 2014-10-28 | Sucampo Ag | Method for modulating stem cell growth |
ITUD20080058A1 (it) | 2008-03-18 | 2009-09-19 | Thankstem S R L | Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali |
WO2009155041A2 (fr) * | 2008-05-28 | 2009-12-23 | Children's Medical Center Corporation | Méthode de modulation de la croissance de cellule souche hématopoïétiquie |
AU2009313290B2 (en) * | 2008-11-06 | 2016-04-21 | Indiana University Research & Technology Corporation | Materials and methods to enhance hematopoietic stem cells engraftment procedures |
US9056085B2 (en) | 2009-02-03 | 2015-06-16 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
WO2010091052A2 (fr) | 2009-02-03 | 2010-08-12 | Children's Medical Center Corporation | Procédés de renforcement de greffe de cellule souche hématopoïétique/progénitrice |
JP5836262B2 (ja) * | 2009-03-19 | 2015-12-24 | フェイト セラピューティクス, インコーポレイテッド | サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法 |
US20120195862A1 (en) * | 2009-04-17 | 2012-08-02 | Children's Medical Center Corporation | Biomechanical induction of hematopoiesis |
EP2251010A1 (fr) | 2009-05-08 | 2010-11-17 | Sygnis Bioscience GmbH & Co. KG | Utilisation de tiabendazole et dérivés correspondants pour la thérapie de conditions neurologiques |
US11459545B2 (en) | 2009-11-15 | 2022-10-04 | Indiana University Research And Technology Corporation | Methods to enhance delivery and engraftment of stem cells including the identification of specific prostaglandin E2 receptors |
US20130129686A1 (en) * | 2009-11-19 | 2013-05-23 | Regents Of The University | Reducing Inflammation Using Cell Therapy |
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CN106214701B (zh) * | 2010-08-12 | 2020-09-25 | 菲特治疗公司 | 改进的造血干细胞和祖细胞疗法 |
PL2663313T3 (pl) | 2011-01-13 | 2019-01-31 | SciPharm S.à r.l. | Sposób zwiększania wszczepiania hematopoetycznych komórek macierzystych |
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CN104066837B (zh) | 2011-12-02 | 2020-12-08 | 菲特治疗公司 | 增强的干细胞组合物 |
EP2785350B1 (fr) | 2011-12-02 | 2018-05-02 | Fate Therapeutics, Inc. | Méthodes améliorées permettant de traiter l'ischémie |
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WO2014081760A1 (fr) | 2012-11-20 | 2014-05-30 | Duke University | Procédés de traitement d'hémoglobinopathies |
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EP2968416A4 (fr) | 2013-03-15 | 2016-08-17 | Fate Therapeutics Inc | Essai d'activité biologique de cellules pour un potentiel thérapeutique |
US9428748B2 (en) * | 2013-06-17 | 2016-08-30 | Hong Gao | Method of expanding hematopoietic stem cells |
JP2015205835A (ja) * | 2014-04-21 | 2015-11-19 | 国立大学法人福井大学 | 中性子線障害防護剤 |
AU2015249751A1 (en) * | 2014-04-23 | 2016-11-10 | Texas Heart Institute | Methods of enhancing stem cell engraftment |
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EP3878948A1 (fr) | 2014-09-16 | 2021-09-15 | Sangamo Therapeutics, Inc. | Procédés et compositions pour ingénierie génomique à médiation par des nucléases et correction du génome dans des cellules souches hématopoïétiques |
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WO2016210292A1 (fr) | 2015-06-25 | 2016-12-29 | Children's Medical Center Corporation | Procédés et compositions se rapportant à l'expansion, l'enrichissement et la conservation de cellules souches hématopoïétiques |
CN105296427A (zh) * | 2015-10-23 | 2016-02-03 | 深圳爱生再生医学科技有限公司 | 造血干细胞的体外扩增培养方法 |
JP7189587B2 (ja) * | 2015-10-30 | 2022-12-14 | 典正 三浦 | メチル化関連酵素hat1とkat8の阻害薬 |
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RU2744603C2 (ru) | 2016-02-12 | 2021-03-11 | Блубёрд Био, Инк. | Композиции, повышающие число копий вектора (чкв), и способы их применения |
US9918994B2 (en) | 2016-03-04 | 2018-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for muscle regeneration using prostaglandin E2 |
CA3014667A1 (fr) * | 2016-03-04 | 2017-09-08 | The Board Of Trustees Of Leland Stanford Junior University | Compositions et methodes de regeneration musculaire a l'aide de la prostaglandine e2 |
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CN110051839A (zh) * | 2019-04-16 | 2019-07-26 | 诺航生物技术(徐州)有限公司 | 一种促进脐带血干细胞体外扩增和增强脐带血干细胞移植后造血重建功能的药物 |
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US11883436B2 (en) | 2020-08-17 | 2024-01-30 | The Board Of Trustees Of The University Of Illinois | Method of preparing hematopoietic stem and progenitor cells for transplantation |
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2007
- 2007-03-26 EP EP18175819.4A patent/EP3424507A1/fr active Pending
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10751373B2 (en) | 2015-07-21 | 2020-08-25 | The Children's Medical Center Corporation | PD-L1 expressing hematopoietic stem cells and uses |
US11642378B2 (en) | 2015-07-21 | 2023-05-09 | The Children's Medical Center Corporation | PD-L1 expressing hematopoietic stem cells and uses |
US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
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