RU2415847C9 - Новые производные циклопента[b]бензофурана и их применение - Google Patents

Новые производные циклопента[b]бензофурана и их применение Download PDF

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Publication number
RU2415847C9
RU2415847C9 RU2006144710/04A RU2006144710A RU2415847C9 RU 2415847 C9 RU2415847 C9 RU 2415847C9 RU 2006144710/04 A RU2006144710/04 A RU 2006144710/04A RU 2006144710 A RU2006144710 A RU 2006144710A RU 2415847 C9 RU2415847 C9 RU 2415847C9
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Russia
Prior art keywords
carbon atoms
formula
ethoxy
hydrogen
alkyl
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RU2006144710/04A
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English (en)
Russian (ru)
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RU2415847C2 (ru
RU2006144710A (ru
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Николь ДИДРИХС (DE)
Николь ДИДРИХС
Томас ФАРИГ (DE)
Томас ФАРИГ
Ирене ГЕРЛАХ (DE)
Ирене ГЕРЛАХ
Жак РАГО (DE)
Жак Раго
Йоахим ШУМАХЕР (DE)
Йоахим Шумахер
Кай ТЕДЕ (DE)
Кай ТЕДЕ
Эрвин ХОРВАТ (DE)
Эрвин ХОРВАТ
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ИнтерМед Дискавери ГмбХ
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P11/06Antiasthmatics
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61P19/00Drugs for skeletal disorders
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
RU2006144710/04A 2004-05-18 2005-05-14 Новые производные циклопента[b]бензофурана и их применение RU2415847C9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004024504A DE102004024504A1 (de) 2004-05-18 2004-05-18 Neue Cylopenta[b]benzofuran-Derivate und ihre Verwendung
DE102004024504.5 2004-05-18

Publications (3)

Publication Number Publication Date
RU2006144710A RU2006144710A (ru) 2008-06-27
RU2415847C2 RU2415847C2 (ru) 2011-04-10
RU2415847C9 true RU2415847C9 (ru) 2011-08-10

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ID=35207782

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Application Number Title Priority Date Filing Date
RU2006144710/04A RU2415847C9 (ru) 2004-05-18 2005-05-14 Новые производные циклопента[b]бензофурана и их применение

Country Status (14)

Country Link
US (1) US8030347B2 (US07794700-20100914-C00152.png)
EP (1) EP1751127B1 (US07794700-20100914-C00152.png)
JP (1) JP2007538031A (US07794700-20100914-C00152.png)
KR (1) KR101215164B1 (US07794700-20100914-C00152.png)
CN (1) CN1989122B (US07794700-20100914-C00152.png)
AU (1) AU2005245104B2 (US07794700-20100914-C00152.png)
BR (1) BRPI0510403A (US07794700-20100914-C00152.png)
CA (1) CA2567404C (US07794700-20100914-C00152.png)
DE (1) DE102004024504A1 (US07794700-20100914-C00152.png)
IL (1) IL179257A (US07794700-20100914-C00152.png)
MX (1) MXPA06013182A (US07794700-20100914-C00152.png)
RU (1) RU2415847C9 (US07794700-20100914-C00152.png)
WO (1) WO2005113529A2 (US07794700-20100914-C00152.png)
ZA (1) ZA200609444B (US07794700-20100914-C00152.png)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
AU2005275181A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1693059A1 (en) * 2005-02-22 2006-08-23 Deutsches Krebsforschungszentrum Use of rocaglamide derivatives as NF-AT-specific inhibitors for the treatment of certain inflammatory diseases
EP2189453A1 (en) * 2008-11-25 2010-05-26 Université Louis Pasteur Rocaglaol derivatives as cardioprotectant agents
EP2457907A1 (en) * 2010-11-16 2012-05-30 Université de Strasbourg Flavagline derivatives as neuroprotective agents
WO2013016658A1 (en) * 2011-07-27 2013-01-31 The Ohio State University Research Foundation Silvestrol, silvestrol analogs and uses thereof
FR3023290B1 (fr) * 2014-07-04 2016-08-19 Pf Medicament Derives de flavaglines
MY196749A (en) 2015-11-25 2023-05-03 Effector Therapeutics Inc Eif4a-inhibiting compounds and methods related thereto
EP3639820A1 (en) 2018-10-16 2020-04-22 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Flavagline derivatives for inhibition of kras oncogene activation
CN110646616B (zh) * 2019-09-05 2023-05-30 桂林理工大学 一种检测血清中人cTnI的超敏荧光猝灭免疫传感器及检测方法
CN110776486B (zh) * 2019-10-23 2022-05-20 中国药科大学 一种苯并呋喃类小分子p2y14受体抑制剂,及其制备和应用
CA3230542A1 (en) 2021-09-01 2023-03-09 Krishnaraj Rajalingam Novel ras inhibitors
CN116077483A (zh) * 2021-11-05 2023-05-09 上海中医药大学 楝酰胺及其类似物的药物用途
CN115385924B (zh) * 2022-10-06 2023-10-13 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种具有抗肿瘤活性的环戊烷苯并呋喃类化合物及其应用
WO2024175659A1 (en) 2023-02-23 2024-08-29 KHR Biotec GmbH 3ah-cyclopenta[b]benzofuran-3a-yl as ras inhibitors
WO2024175662A1 (en) 2023-02-23 2024-08-29 KHR Biotec GmbH Flavagline derivatives as ras inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19934952A1 (de) * 1998-07-30 2000-02-03 Novartis Ag Cyclopentabenzofuran-Derivate
DE19835324A1 (de) * 1998-08-05 2000-02-10 Bayer Ag Cyclopentabenzofuran-Derivate und ihre Verwendung
DE19835325A1 (de) * 1998-08-05 2000-02-10 Bayer Ag Verwendung von Cyclopentabenzofuran-Derivaten zur Bekämpfung von NF-kB abhängigen Krankheiten
DE10158561A1 (de) * 2001-11-29 2003-06-12 Bayer Ag Neue Verwendung von Cyclopentabenzofuranen

Also Published As

Publication number Publication date
KR20070011522A (ko) 2007-01-24
RU2415847C2 (ru) 2011-04-10
CA2567404C (en) 2014-04-01
DE102004024504A1 (de) 2006-02-16
JP2007538031A (ja) 2007-12-27
WO2005113529A3 (de) 2006-02-09
RU2006144710A (ru) 2008-06-27
IL179257A (en) 2013-02-28
US20090018113A1 (en) 2009-01-15
CA2567404A1 (en) 2005-12-01
EP1751127B1 (de) 2012-07-11
AU2005245104A1 (en) 2005-12-01
MXPA06013182A (es) 2007-02-14
CN1989122B (zh) 2013-07-24
ZA200609444B (en) 2008-01-30
WO2005113529A2 (de) 2005-12-01
CN1989122A (zh) 2007-06-27
EP1751127A2 (de) 2007-02-14
KR101215164B1 (ko) 2012-12-24
AU2005245104B2 (en) 2011-07-28
BRPI0510403A (pt) 2007-10-23
US8030347B2 (en) 2011-10-04
IL179257A0 (en) 2007-03-08

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