RU2410081C2 - Офтальмические композиции и способы лечения глаз - Google Patents

Офтальмические композиции и способы лечения глаз Download PDF

Info

Publication number
RU2410081C2
RU2410081C2 RU2007117637/15A RU2007117637A RU2410081C2 RU 2410081 C2 RU2410081 C2 RU 2410081C2 RU 2007117637/15 A RU2007117637/15 A RU 2007117637/15A RU 2007117637 A RU2007117637 A RU 2007117637A RU 2410081 C2 RU2410081 C2 RU 2410081C2
Authority
RU
Russia
Prior art keywords
eye
composition
compositions
compatible
component
Prior art date
Application number
RU2007117637/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2007117637A (ru
Inventor
Джозеф Дж. ВЕИДЖ (US)
Джозеф Дж. ВЕИДЖ
Питер А. СИММОНС (US)
Питер А. СИММОНС
Джоан-Эн ЧЕНГ-ЛИН (US)
Джоан-Эн ЧЕНГ-ЛИН
Original Assignee
Аллерган, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36218032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2410081(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Аллерган, Инк. filed Critical Аллерган, Инк.
Publication of RU2007117637A publication Critical patent/RU2007117637A/ru
Application granted granted Critical
Publication of RU2410081C2 publication Critical patent/RU2410081C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1732—Lectins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2007117637/15A 2004-11-16 2005-11-14 Офтальмические композиции и способы лечения глаз RU2410081C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/990,811 2004-11-16
US10/990,811 US8569367B2 (en) 2004-11-16 2004-11-16 Ophthalmic compositions and methods for treating eyes

Publications (2)

Publication Number Publication Date
RU2007117637A RU2007117637A (ru) 2008-12-27
RU2410081C2 true RU2410081C2 (ru) 2011-01-27

Family

ID=36218032

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007117637/15A RU2410081C2 (ru) 2004-11-16 2005-11-14 Офтальмические композиции и способы лечения глаз

Country Status (23)

Country Link
US (11) US8569367B2 (https=)
EP (4) EP3777836A1 (https=)
JP (1) JP5179880B2 (https=)
KR (1) KR101344602B1 (https=)
CN (1) CN101056618B (https=)
AR (1) AR052031A1 (https=)
AU (2) AU2005306721B2 (https=)
BR (2) BRPI0518173B8 (https=)
CA (1) CA2588044C (https=)
CY (2) CY1116545T1 (https=)
DK (3) DK1811959T4 (https=)
ES (3) ES2543974T3 (https=)
HU (2) HUE026575T2 (https=)
IL (1) IL182532A (https=)
NO (3) NO347855B1 (https=)
NZ (2) NZ597106A (https=)
PL (3) PL218364B1 (https=)
PT (2) PT1811959E (https=)
RU (1) RU2410081C2 (https=)
SI (2) SI1811959T2 (https=)
TW (1) TWI369996B (https=)
WO (1) WO2006055454A2 (https=)
ZA (1) ZA200702917B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2625301C2 (ru) * 2011-12-23 2017-07-13 Юниверсити Ов Уэстерн Сидни Офтальмологическая композиция

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147584A1 (en) * 2004-01-05 2005-07-07 Allergan, Inc. Compositions and methods comprising memantine and polyanionic polymers
US7220422B2 (en) 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
US8569367B2 (en) * 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
TWI393567B (zh) 2005-03-31 2013-04-21 Bausch & Lomb 治療乾眼之組合物及相關之製造方法及使用方法
TW200722109A (en) * 2005-03-31 2007-06-16 Bausch & Lomb Polysaccharide and polyol composition for treating dry eye and related methods of manufacture and methods of use
WO2007005421A2 (en) * 2005-07-01 2007-01-11 Bausch & Lomb Incorporated Long lasting alginate dry eye, related methods of manufacture and methods of use
AU2006265248B2 (en) * 2005-07-01 2011-12-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of L-carnitine or of alkanoyl L-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye-drops
CN1939534B (zh) * 2005-09-27 2010-12-01 长春金赛药业股份有限公司 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂
DE102005055275A1 (de) * 2005-11-17 2007-05-24 Ursapharm Arzneimittel Gmbh & Co. Kg Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung
US20080057022A1 (en) * 2006-08-30 2008-03-06 Erning Xia Ophthalmic Pharmaceutical Compositions and Uses Thereof
US8138156B2 (en) 2006-10-18 2012-03-20 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
US20080095754A1 (en) * 2006-10-18 2008-04-24 Burke Susan E Ophthalmic compositions comprising diglycine
CN101534812B (zh) * 2006-12-11 2012-09-05 希格马托制药工业公司 L-卡尼汀制备用于治疗角膜疾病的滴眼剂形式药物的用途
DE102006060953A1 (de) * 2006-12-12 2008-08-07 Farco-Pharma Gmbh Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes
WO2008071528A1 (en) * 2006-12-14 2008-06-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine or of alkanoyl l-carnitines for the preparation of a physiological supplement or medicament for ophthalmic use in the form of eye drops
US20080148689A1 (en) * 2006-12-20 2008-06-26 Bausch & Lomb Incorporated Packaging solutions
US8629099B2 (en) 2008-03-25 2014-01-14 Bausch & Lomb Incorporated Ophthalmic compositions comprising a dipeptide
WO2010047927A1 (en) * 2008-10-20 2010-04-29 Allergan, Inc. Ophthalmic compositions useful for improving visual acuity
MX358504B (es) * 2009-06-05 2018-08-21 Allergan Inc Lagrimas artificiales y usos terapeuticos.
ITMI20100319A1 (it) * 2010-02-26 2011-08-27 Lo Li Pharma Srl Composizioni comprendenti mioinositolo e il loro uso nel trattamento delle malattie respiratorie.
US9636355B2 (en) 2011-09-22 2017-05-02 Theo Holdings, Llc Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
ES2797650T3 (es) 2011-12-07 2020-12-03 Allergan Inc Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal
US8324171B1 (en) 2012-02-06 2012-12-04 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
US8664180B2 (en) 2012-02-06 2014-03-04 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
US10085960B2 (en) 2012-03-30 2018-10-02 Brien Holden Vision Institute Methods and compositions for reducing ocular discomfort
PT2950783T (pt) * 2013-02-01 2019-08-21 Allergan Inc Lágrimas artificiais compreendendo hialuronato de sódio e carboximetilcelulose
CA2994222C (en) 2014-08-20 2020-09-08 Silk Technologies, Ltd. Fibroin-derived protein composition
JP6768653B2 (ja) 2014-11-25 2020-10-14 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 安定したオメガ−３眼科用組成物
ITUB20153104A1 (it) * 2015-08-13 2017-02-13 Sooft Italia S P A Contrada Molino 17 68333 Montegiorgio Fm Composizione ed uso di collirio a base di inositolo per migliorare l'accomodazione visiva dei pazienti
KR20180074674A (ko) 2015-10-23 2018-07-03 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 조직 내 레이저 유도된 콜라겐 가교결합
SG11201808804TA (en) 2016-04-08 2018-11-29 Univ Cornell A method to enhance wound healing using silk-derived protein
US11497403B2 (en) 2016-06-10 2022-11-15 The Trustees Of Columbia University In The City Of New York Devices, methods, and systems for detection of collagen tissue features
RU2623205C1 (ru) * 2016-07-13 2017-06-22 Станислав Анатольевич Кедик Офтальмологический гель таурина
US11242367B2 (en) 2016-08-12 2022-02-08 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
US11666481B1 (en) 2017-12-01 2023-06-06 The Trustees Of Columbia University In The City Of New York Diagnosis and treatment of collagen-containing tissues
SG10201907137RA (en) * 2019-08-02 2021-03-30 Singapore Health Serv Pte Ltd Use of an osmolyte in manufacture of a medicament for treatment of ocular disorders
AU2020419590A1 (en) 2019-11-15 2022-06-30 Silk Technologies, Ltd. Stable formulations of silk-derived protein
CN111467349B (zh) * 2020-05-14 2021-06-01 华熙生物科技股份有限公司 人工泪液及其制备方法
WO2022189552A1 (en) * 2021-03-10 2022-09-15 Bausch + Lomb Ireland Limited Preservative-free contact lens treating solution
US12012238B2 (en) * 2021-05-26 2024-06-18 Bausch + Lomb Ireland Limited Packaging solutions
CA3223191A1 (en) * 2021-09-03 2023-03-09 University Of Utah Research Foundation Compositions and methods for diagnosing, detecting and treating eosinophil-related diseases
IT202300019488A1 (it) * 2023-09-21 2025-03-21 D&V Farma Soc A Responsabilita Limitata Composizioni, usi e metodi per il trattamento della sindrome dell’occhio secco o per promuovere la guarigione delle ferite corneali
WO2025175150A1 (en) * 2024-02-16 2025-08-21 Allergan, Inc. Enhanced artificial tear formulations

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957744A (en) * 1986-10-13 1990-09-18 Fidia, S.P.A. Cross-linked esters of hyaluronic acid
EP0436726A1 (en) * 1989-08-03 1991-07-17 Eisai Co., Ltd. Method of photostabilizing eyewash
US5037851A (en) * 1988-11-15 1991-08-06 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of acetyl l-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
US5221696A (en) * 1989-03-29 1993-06-22 Alcon Laboratories, Inc. Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs
US5432199A (en) * 1988-12-01 1995-07-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of acetyl D-carnitine in the therapeutic treatment of glaucoma, and pharmaceutical compositions useful in such treatment
WO1998041208A1 (en) * 1997-03-17 1998-09-24 Novartis Ag Compositions and methods for reducing ocular hypertension
US5883127A (en) * 1996-12-03 1999-03-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Use of lower alkanoyl L-carnitines to produce a medicament suitable for the therapeutic treatment of retinopathies
WO2002038161A1 (en) * 2000-11-08 2002-05-16 Bio-Concept Laboratories Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
RU2211027C2 (ru) * 1998-10-23 2003-08-27 Идеа Аг Способ конструирования, проверки и применения ассоциатов макромолекул и комплексных агрегатов с повышенной полезной нагрузкой и контролируемой степенью ассоциации/диссоциации
RU2216346C1 (ru) * 2002-06-10 2003-11-20 Семенова Наталья Викторовна Средство и способ для биогенной стимуляции организма
RU2234337C2 (ru) * 1997-09-26 2004-08-20 Ноувен Фамэсьютикэлз, Инк. Биоадгезивная композиция (варианты), способ ее получения (варианты), устройство для доставки через слизистую оболочку активного агента, способ пролонгированного местного введения одного или более активных агентов субъекту (варианты) и способ сокращения времени, требуемого для приклеивания композиции к слизистой ткани

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1781701A (en) 1928-05-16 1930-11-18 Phillips Morris Godfrey Philip Machine for removing flags and other adhering leaf from the stalks of tobacco leaves
US3278447A (en) 1963-12-02 1966-10-11 Cloro Bac Products Inc Process for stabilizing chlorine dioxide solution
US4201706A (en) * 1978-09-22 1980-05-06 Burton, Parsons & Company, Inc. Treatment of corneal edema
DE3066859D1 (en) 1979-10-26 1984-04-12 Smith & Nephew Ass Autoclavable emulsions
EP0145710A1 (en) * 1983-05-25 1985-06-26 Alcon Laboratories, Inc. Ophthalmic solution
JPS6436255A (en) * 1987-07-31 1989-02-07 Fujitsu Ltd Feeding circuit
US5192535A (en) * 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5681555A (en) * 1991-04-22 1997-10-28 Gleich; Gerald J. Method for the treatment of bronchial asthma by parenteral administration of anionic polymers
DE4229494A1 (de) † 1992-09-04 1994-03-10 Basotherm Gmbh Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks
JP3431216B2 (ja) 1993-06-18 2003-07-28 千代田化工建設株式会社 触媒層支持構造
CN1160346A (zh) 1994-09-14 1997-09-24 大正制药株式会社 用于修复角膜损伤的滴眼液
US5980865A (en) * 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
US5847294A (en) * 1996-04-09 1998-12-08 Amherst Process Instruments, Inc. Apparatus for determining powder flowability
JPH1036255A (ja) * 1996-07-24 1998-02-10 Nikken Chem Co Ltd 眼圧降下用点眼剤
FI106923B (fi) 1997-01-03 2001-05-15 Cultor Ltd Finnsugar Bioproduc Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa
US6770675B2 (en) * 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
IT1302307B1 (it) * 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil
WO2000029030A1 (en) 1998-11-13 2000-05-25 Continental Projects Limited Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions
US6228392B1 (en) * 1999-04-29 2001-05-08 Gene Tools, Llc Osmotic delivery composition, solution, and method
KR100354606B1 (ko) 2000-02-01 2002-09-30 주식회사 중외제약 다목적 콘택트 렌즈 관리 용액 조성물
DK2153819T3 (da) * 2000-07-14 2012-12-03 Allergan Inc Anvendelse af en opløselighedsforbedrende bestanddel i en vandig sammensætning omfattende brimonidintartrat
CA2355814C (en) * 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
US8557868B2 (en) 2000-11-04 2013-10-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions using low molecular weight amines
US20030069410A1 (en) 2001-06-14 2003-04-10 Isis Pharmaceuticals, Inc. Methods for preparing oligonucleotides having chiral phosphorothioate linkages
AR036122A1 (es) 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita
US6936589B2 (en) 2001-09-28 2005-08-30 Albert T. Naito Parenteral delivery systems
US7045121B2 (en) * 2001-12-14 2006-05-16 Allergan, Inc. Ophthalmic compositions for lubricating eyes and methods for making and using same
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
AU2003259145A1 (en) 2002-07-17 2004-02-02 Spencer P. Thornton Treatment for dry eye syndrome
EP1551399A4 (en) * 2002-09-30 2011-01-05 Mark A Babizhayev METHOD FOR THE TOPICAL TREATMENT OF EYE DISEASES AND COMPOSITION AND DEVICE FOR THIS TREATMENT
ITRM20020492A1 (it) 2002-10-01 2004-04-02 Sigma Tau Ind Farmaceuti Uso della propionil l-carnitina per la preparazione di un medicamento per il trattamento del glaucoma.
US20040137079A1 (en) 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
JPWO2004084877A1 (ja) 2003-03-26 2006-06-29 株式会社メニコン 眼科用組成物
US20050009836A1 (en) * 2003-06-26 2005-01-13 Laskar Paul A. Ophthalmic composition containing quinolones and method of use
US8569367B2 (en) * 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
BRPI0808410A2 (pt) 2007-02-28 2015-06-23 Aciex Therapeutics Inc Métodos e composições para normalizar secreções da glândula meibomiana
JP4929245B2 (ja) 2008-07-31 2012-05-09 株式会社ベッセル工業 工具類のグリップ
MX358504B (es) 2009-06-05 2018-08-21 Allergan Inc Lagrimas artificiales y usos terapeuticos.
US9907826B2 (en) * 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957744A (en) * 1986-10-13 1990-09-18 Fidia, S.P.A. Cross-linked esters of hyaluronic acid
US5037851A (en) * 1988-11-15 1991-08-06 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of acetyl l-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
US5432199A (en) * 1988-12-01 1995-07-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of acetyl D-carnitine in the therapeutic treatment of glaucoma, and pharmaceutical compositions useful in such treatment
US5221696A (en) * 1989-03-29 1993-06-22 Alcon Laboratories, Inc. Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs
EP0436726A1 (en) * 1989-08-03 1991-07-17 Eisai Co., Ltd. Method of photostabilizing eyewash
US5883127A (en) * 1996-12-03 1999-03-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Use of lower alkanoyl L-carnitines to produce a medicament suitable for the therapeutic treatment of retinopathies
WO1998041208A1 (en) * 1997-03-17 1998-09-24 Novartis Ag Compositions and methods for reducing ocular hypertension
RU2234337C2 (ru) * 1997-09-26 2004-08-20 Ноувен Фамэсьютикэлз, Инк. Биоадгезивная композиция (варианты), способ ее получения (варианты), устройство для доставки через слизистую оболочку активного агента, способ пролонгированного местного введения одного или более активных агентов субъекту (варианты) и способ сокращения времени, требуемого для приклеивания композиции к слизистой ткани
RU2211027C2 (ru) * 1998-10-23 2003-08-27 Идеа Аг Способ конструирования, проверки и применения ассоциатов макромолекул и комплексных агрегатов с повышенной полезной нагрузкой и контролируемой степенью ассоциации/диссоциации
WO2002038161A1 (en) * 2000-11-08 2002-05-16 Bio-Concept Laboratories Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
RU2216346C1 (ru) * 2002-06-10 2003-11-20 Семенова Наталья Викторовна Средство и способ для биогенной стимуляции организма

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2625301C2 (ru) * 2011-12-23 2017-07-13 Юниверсити Ов Уэстерн Сидни Офтальмологическая композиция

Also Published As

Publication number Publication date
NO20072170L (no) 2007-08-15
CY1116545T1 (el) 2017-03-15
WO2006055454A3 (en) 2006-08-03
PL1811959T3 (pl) 2015-11-30
US20140256675A1 (en) 2014-09-11
ES2550616T3 (es) 2015-11-11
US20130190398A1 (en) 2013-07-25
US10213405B2 (en) 2019-02-26
NZ583757A (en) 2011-11-25
BRPI0518173A (pt) 2008-11-04
CA2588044A1 (en) 2006-05-26
EP2422765B1 (en) 2015-04-29
US20140045773A1 (en) 2014-02-13
US9668997B2 (en) 2017-06-06
AU2012203398B2 (en) 2015-01-15
CA2588044C (en) 2014-05-27
SI1811959T2 (sl) 2022-10-28
EP1811959B1 (en) 2015-09-02
PL2422765T3 (pl) 2015-10-30
US20160256424A1 (en) 2016-09-08
HUE025116T2 (en) 2016-01-28
HK1107027A1 (zh) 2008-03-28
RU2007117637A (ru) 2008-12-27
TWI369996B (en) 2012-08-11
IL182532A0 (en) 2007-09-20
SI1811959T1 (sl) 2015-11-30
US20140045939A1 (en) 2014-02-13
EP2952178A1 (en) 2015-12-09
ES2550616T5 (es) 2022-09-29
AU2005306721A1 (en) 2006-05-26
US9254324B2 (en) 2016-02-09
BRPI0518173B8 (pt) 2021-05-25
BR122019023144B8 (pt) 2021-07-27
CN101056618B (zh) 2015-02-11
AU2005306721B2 (en) 2012-03-08
DK1811959T3 (en) 2015-11-23
EP3777836A1 (en) 2021-02-17
WO2006055454A2 (en) 2006-05-26
HK1218620A1 (en) 2017-03-03
DK2422765T3 (en) 2015-08-03
AR052031A1 (es) 2007-02-28
BRPI0518173A8 (pt) 2018-01-23
SI2422765T1 (sl) 2015-09-30
HUE026575T2 (en) 2016-06-28
TW200631605A (en) 2006-09-16
US8569370B2 (en) 2013-10-29
ES2842226T3 (es) 2021-07-13
JP2008520671A (ja) 2008-06-19
EP1811959B2 (en) 2022-06-15
NO347855B1 (no) 2024-04-22
IL182532A (en) 2013-10-31
EP1811959A2 (en) 2007-08-01
DK2952178T3 (da) 2020-12-07
US20230404961A1 (en) 2023-12-21
DK1811959T4 (da) 2022-06-27
US20210401789A1 (en) 2021-12-30
AU2012203398A1 (en) 2012-06-28
US20060106104A1 (en) 2006-05-18
PT1811959E (pt) 2015-11-10
PL218364B1 (pl) 2014-11-28
US20180021282A1 (en) 2018-01-25
US20190365692A1 (en) 2019-12-05
PT2422765E (pt) 2015-09-16
EP2422765A1 (en) 2012-02-29
EP2952178B1 (en) 2020-09-02
NO20240132A1 (no) 2007-08-15
JP5179880B2 (ja) 2013-04-10
US8729125B2 (en) 2014-05-20
NO346214B1 (no) 2022-04-25
US8569367B2 (en) 2013-10-29
BRPI0518173B1 (pt) 2020-05-19
KR101344602B1 (ko) 2013-12-31
US20250186385A1 (en) 2025-06-12
ZA200702917B (en) 2008-09-25
CY1116936T1 (el) 2017-04-05
KR20070084264A (ko) 2007-08-24
NO20220060A1 (https=) 2007-08-15
CN101056618A (zh) 2007-10-17
PL383268A1 (pl) 2008-02-18
BR122019023144B1 (pt) 2021-02-09
NZ597106A (en) 2013-06-28
ES2543974T3 (es) 2015-08-26

Similar Documents

Publication Publication Date Title
RU2410081C2 (ru) Офтальмические композиции и способы лечения глаз
JP2008520671A5 (https=)
HK40047402A (en) Ophthalmic compositions and methods for treating eyes
HK1218620B (en) Ophthalmic compositions and methods for treating eyes
HK1107027B (en) Ophthalmic compositions and methods for treating eyes