RU2403255C2 - 6,7-ненасыщенное 7-карбамоилзамещенное производное морфинана - Google Patents

6,7-ненасыщенное 7-карбамоилзамещенное производное морфинана Download PDF

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Publication number
RU2403255C2
RU2403255C2 RU2007148412/04A RU2007148412A RU2403255C2 RU 2403255 C2 RU2403255 C2 RU 2403255C2 RU 2007148412/04 A RU2007148412/04 A RU 2007148412/04A RU 2007148412 A RU2007148412 A RU 2007148412A RU 2403255 C2 RU2403255 C2 RU 2403255C2
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RU
Russia
Prior art keywords
optionally substituted
compound
lower alkyl
solvate
pharmaceutically acceptable
Prior art date
Application number
RU2007148412/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2007148412A (ru
Inventor
Масанао ИНАГАКИ (JP)
Масанао ИНАГАКИ
Син-Итиро ХАРА (JP)
Син-Итиро ХАРА
Нобухиро ХАГА (JP)
Нобухиро ХАГА
Йосинори ТАМУРА (JP)
Йосинори ТАМУРА
Йосихиса ГОТО (JP)
Йосихиса ГОТО
Цуйоси ХАСЕГАВА (JP)
Цуйоси ХАСЕГАВА
Original Assignee
Сионоги Энд Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сионоги Энд Ко., Лтд. filed Critical Сионоги Энд Ко., Лтд.
Publication of RU2007148412A publication Critical patent/RU2007148412A/ru
Application granted granted Critical
Publication of RU2403255C2 publication Critical patent/RU2403255C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2007148412/04A 2005-05-25 2006-05-25 6,7-ненасыщенное 7-карбамоилзамещенное производное морфинана RU2403255C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2005-151864 2005-05-25
JP2006065762 2006-03-10
JP2006/065762 2006-03-10
JPPCT/JP2006/310231 2006-05-23

Publications (2)

Publication Number Publication Date
RU2007148412A RU2007148412A (ru) 2009-06-27
RU2403255C2 true RU2403255C2 (ru) 2010-11-10

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007148412/04A RU2403255C2 (ru) 2005-05-25 2006-05-25 6,7-ненасыщенное 7-карбамоилзамещенное производное морфинана

Country Status (20)

Country Link
US (4) US8084460B2 (cg-RX-API-DMAC10.html)
EP (1) EP1889848B8 (cg-RX-API-DMAC10.html)
JP (1) JP4323547B2 (cg-RX-API-DMAC10.html)
KR (1) KR100912782B1 (cg-RX-API-DMAC10.html)
CN (1) CN101228172B (cg-RX-API-DMAC10.html)
AU (1) AU2006250390B2 (cg-RX-API-DMAC10.html)
BE (1) BE2019C533I2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0610343B8 (cg-RX-API-DMAC10.html)
CA (1) CA2609733C (cg-RX-API-DMAC10.html)
DK (1) DK1889848T3 (cg-RX-API-DMAC10.html)
ES (1) ES2525215T3 (cg-RX-API-DMAC10.html)
FR (1) FR19C1042I2 (cg-RX-API-DMAC10.html)
HU (1) HUS1900034I1 (cg-RX-API-DMAC10.html)
MX (1) MX2007014588A (cg-RX-API-DMAC10.html)
NL (1) NL300996I2 (cg-RX-API-DMAC10.html)
PL (1) PL1889848T3 (cg-RX-API-DMAC10.html)
PT (1) PT1889848E (cg-RX-API-DMAC10.html)
RU (1) RU2403255C2 (cg-RX-API-DMAC10.html)
TW (1) TWI311056B (cg-RX-API-DMAC10.html)
WO (2) WO2006126529A1 (cg-RX-API-DMAC10.html)

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WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
EP2240022B1 (en) * 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
MX347741B (es) * 2008-09-16 2017-05-10 Nektar Therapeutics Opioides pegilados con bajo potencial de abuso.
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
CN102906099A (zh) * 2010-05-13 2013-01-30 株式会社绿十字 作为神经保护剂的基于(+)-3-羟基吗啡喃的多环衍生物
WO2012063933A1 (ja) * 2010-11-12 2012-05-18 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体の結晶およびその製造方法
PL2851075T3 (pl) 2012-05-14 2022-02-21 Shionogi & Co., Ltd. Preparat zawierający pochodną 6,7-nienasyconego-7-karbamoilomorfinanu
EP3560487A4 (en) * 2016-12-26 2020-07-29 Shionogi & Co., Ltd. PRODUCTION METHOD FOR FORMULATION WITH IMPROVED UNIFORMITY OF CONTENT
TW202528300A (zh) 2018-04-12 2025-07-16 美商莫菲克醫療股份有限公司 人類整合素α4β7拮抗劑
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
ES3035561T3 (en) 2019-10-16 2025-09-04 Morphic Therapeutic Inc Inhibiting human integrin alpha4beta7
EP4062973A4 (en) 2019-11-20 2023-11-29 Shionogi & Co., Ltd 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina

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WO2004007503A1 (ja) * 2002-07-11 2004-01-22 Toray Industries, Inc. 悪心・嘔吐の治療または予防剤
RU2004108210A (ru) * 2001-08-23 2005-04-10 Акцо Нобель Н.В. (NL) C-14 окисление производных морфина

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WO2012063933A1 (ja) 2010-11-12 2012-05-18 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体の結晶およびその製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1508960A3 (ru) * 1984-07-05 1989-09-15 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных бензоатных эфиров 3-оксиморфинанов
US20010047005A1 (en) * 1999-09-29 2001-11-29 Farrar John J. Novel methods and compositions involving opioids and antagonists thereof
RU2004108210A (ru) * 2001-08-23 2005-04-10 Акцо Нобель Н.В. (NL) C-14 окисление производных морфина
WO2004007503A1 (ja) * 2002-07-11 2004-01-22 Toray Industries, Inc. 悪心・嘔吐の治療または予防剤

Also Published As

Publication number Publication date
WO2006126529A1 (ja) 2006-11-30
NL300996I2 (nl) 2019-07-30
KR100912782B1 (ko) 2009-08-18
TW200726470A (en) 2007-07-16
NL300996I1 (nl) 2019-07-03
BRPI0610343B8 (pt) 2021-05-25
US8536192B2 (en) 2013-09-17
DK1889848T3 (en) 2014-12-01
CN101228172B (zh) 2013-04-03
RU2007148412A (ru) 2009-06-27
PL1889848T3 (pl) 2015-04-30
US8084460B2 (en) 2011-12-27
BRPI0610343A2 (pt) 2010-06-15
BRPI0610343B1 (pt) 2020-03-10
TWI311056B (en) 2009-06-21
USRE46375E1 (en) 2017-04-25
US20090203723A1 (en) 2009-08-13
CA2609733C (en) 2011-07-19
WO2006126637A1 (ja) 2006-11-30
EP1889848B1 (en) 2014-10-15
JP4323547B2 (ja) 2009-09-02
AU2006250390A1 (en) 2006-11-30
MX2007014588A (es) 2008-01-24
CA2609733A1 (en) 2006-11-30
ES2525215T3 (es) 2014-12-19
USRE46365E1 (en) 2017-04-11
US20120135978A1 (en) 2012-05-31
CN101228172A (zh) 2008-07-23
PT1889848E (pt) 2014-12-09
FR19C1042I2 (fr) 2020-06-19
EP1889848B8 (en) 2014-12-17
HUS1900034I1 (hu) 2019-07-29
EP1889848A1 (en) 2008-02-20
JPWO2006126637A1 (ja) 2008-12-25
FR19C1042I1 (cg-RX-API-DMAC10.html) 2019-08-09
BE2019C533I2 (cg-RX-API-DMAC10.html) 2025-12-10
AU2006250390B2 (en) 2010-07-08
KR20080014791A (ko) 2008-02-14
EP1889848A4 (en) 2011-08-10

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