RU2394906C2 - Генетически модифицированный микроорганизм и способ получения макролидного соединения с гидроксильной группой в 16-положении с использованием таких микроорганизмов - Google Patents

Генетически модифицированный микроорганизм и способ получения макролидного соединения с гидроксильной группой в 16-положении с использованием таких микроорганизмов Download PDF

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RU2394906C2
RU2394906C2 RU2007148928/13A RU2007148928A RU2394906C2 RU 2394906 C2 RU2394906 C2 RU 2394906C2 RU 2007148928/13 A RU2007148928/13 A RU 2007148928/13A RU 2007148928 A RU2007148928 A RU 2007148928A RU 2394906 C2 RU2394906 C2 RU 2394906C2
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Казухиро МАТИДА (JP)
Казухиро МАТИДА
Ясухиде АРИТОКУ (JP)
Ясухиде АРИТОКУ
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Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Мершан Корпорейшн
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

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RU2007148928/13A 2005-05-26 2006-05-24 Генетически модифицированный микроорганизм и способ получения макролидного соединения с гидроксильной группой в 16-положении с использованием таких микроорганизмов RU2394906C2 (ru)

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JP2005154114 2005-05-26
JP2005-154114 2005-05-26

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RU2007148928A RU2007148928A (ru) 2009-07-10
RU2394906C2 true RU2394906C2 (ru) 2010-07-20

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US (1) US20090215134A1 (cg-RX-API-DMAC7.html)
EP (1) EP1911843B1 (cg-RX-API-DMAC7.html)
JP (1) JPWO2006126723A1 (cg-RX-API-DMAC7.html)
KR (1) KR20080012845A (cg-RX-API-DMAC7.html)
CN (1) CN101184838B (cg-RX-API-DMAC7.html)
AU (1) AU2006250304B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0610145A2 (cg-RX-API-DMAC7.html)
CA (1) CA2608841A1 (cg-RX-API-DMAC7.html)
IL (1) IL187081A0 (cg-RX-API-DMAC7.html)
NO (1) NO20075911L (cg-RX-API-DMAC7.html)
NZ (1) NZ562921A (cg-RX-API-DMAC7.html)
RU (1) RU2394906C2 (cg-RX-API-DMAC7.html)
SG (1) SG148168A1 (cg-RX-API-DMAC7.html)
TW (1) TW200716744A (cg-RX-API-DMAC7.html)
WO (1) WO2006126723A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2707730C2 (ru) * 2014-05-15 2019-11-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиридиновые соединения пладиенолида и способы применения
US10745387B2 (en) 2015-11-18 2020-08-18 Eisai R&D Management Co., Ltd. Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof
RU2807278C2 (ru) * 2014-05-15 2023-11-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиридиновые соединения пладиенолида и способы применения

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AU2005265443B2 (en) * 2004-07-20 2008-09-04 Eisai R & D Management Co., Ltd DNA coding for polypeptide participating in biosynthesis of pladienolide
CN102010403A (zh) 2005-10-13 2011-04-13 卫材R&D管理有限公司 普拉二烯内酯b和普拉二烯内酯d的全合成
CN101730693A (zh) 2007-07-06 2010-06-09 卫材R&D管理有限公司 大环内酯系化合物的制造方法及其制造中间体
JP5524053B2 (ja) * 2008-06-04 2014-06-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハーボキシジエンの生合成に関与するポリペプチドをコードするｄｎａ
CN110408643B (zh) * 2018-11-30 2023-08-22 云南大学 一种提高自溶链霉菌洋橄榄叶素及其衍生物产量的方法
CN115247179B (zh) * 2021-04-25 2024-03-12 上海健康医学院 一种聚酮化合物骨架及其后修饰物的生物合成基因簇及其应用

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RU2327486C1 (ru) * 2007-07-04 2008-06-27 Валентина Васильевна Малиновская Лекарственное средство для лечения инфекционно-воспалительных заболеваний, обладающее иммуномодулирующим, антивирусным, антибактериальным, антиоксидантным, мембраностабилизирующим, противовоспалительным, антитоксическим свойствами

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WO2006009276A1 (ja) * 2004-07-20 2006-01-26 Eisai R & D Management Co., Ltd. プラジエノライドの生合成に関与するポリペプチドをコードするｄｎａ
RU2327486C1 (ru) * 2007-07-04 2008-06-27 Валентина Васильевна Малиновская Лекарственное средство для лечения инфекционно-воспалительных заболеваний, обладающее иммуномодулирующим, антивирусным, антибактериальным, антиоксидантным, мембраностабилизирующим, противовоспалительным, антитоксическим свойствами

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2707730C2 (ru) * 2014-05-15 2019-11-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиридиновые соединения пладиенолида и способы применения
RU2807278C2 (ru) * 2014-05-15 2023-11-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиридиновые соединения пладиенолида и способы применения
US10745387B2 (en) 2015-11-18 2020-08-18 Eisai R&D Management Co., Ltd. Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof
RU2743349C2 (ru) * 2015-11-18 2021-02-17 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Твердые формы пладиенолидпиридиновых соединений и способы их применения
RU2813597C2 (ru) * 2018-04-09 2024-02-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Определенные соединения пладиенолида и способы их применения
RU2815064C2 (ru) * 2018-04-12 2024-03-11 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные пладиенолида в качестве средств, оказывающих целенаправленное воздействие на сплайсосому, для лечения рака

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BRPI0610145A2 (pt) 2010-06-01
WO2006126723A1 (ja) 2006-11-30
CA2608841A1 (en) 2006-11-30
JPWO2006126723A1 (ja) 2008-12-25
CN101184838B (zh) 2011-06-15
SG148168A1 (en) 2008-12-31
IL187081A0 (cg-RX-API-DMAC7.html) 2008-02-09
KR20080012845A (ko) 2008-02-12
TW200716744A (en) 2007-05-01
AU2006250304B2 (en) 2010-12-09
EP1911843B1 (en) 2012-03-14
RU2007148928A (ru) 2009-07-10
NO20075911L (no) 2008-02-26
NZ562921A (en) 2009-06-26
US20090215134A1 (en) 2009-08-27
EP1911843A4 (en) 2009-01-07
AU2006250304A1 (en) 2006-11-30
EP1911843A1 (en) 2008-04-16
CN101184838A (zh) 2008-05-21

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