AU2006250304B2 - Genetically modified microorganism and process for production of macrolide compound using the microorganism - Google Patents

Genetically modified microorganism and process for production of macrolide compound using the microorganism Download PDF

Info

Publication number
AU2006250304B2
AU2006250304B2 AU2006250304A AU2006250304A AU2006250304B2 AU 2006250304 B2 AU2006250304 B2 AU 2006250304B2 AU 2006250304 A AU2006250304 A AU 2006250304A AU 2006250304 A AU2006250304 A AU 2006250304A AU 2006250304 B2 AU2006250304 B2 AU 2006250304B2
Authority
AU
Australia
Prior art keywords
sequence
dna
nucleotides
modified
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006250304A
Other languages
English (en)
Other versions
AU2006250304A1 (en
Inventor
Yasuhide Aritoku
Kazuhiro Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Microbiopharm Japan Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Microbiopharm Japan Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Microbiopharm Japan Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of AU2006250304A1 publication Critical patent/AU2006250304A1/en
Application granted granted Critical
Publication of AU2006250304B2 publication Critical patent/AU2006250304B2/en
Assigned to EISAI R & D MANAGEMENT CO., LTD., MICROBIOPHARM JAPAN CO., LTD. reassignment EISAI R & D MANAGEMENT CO., LTD. Request for Assignment Assignors: EISAI R & D MANAGEMENT CO., LTD., MERCIAN CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2006250304A 2005-05-26 2006-05-24 Genetically modified microorganism and process for production of macrolide compound using the microorganism Ceased AU2006250304B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005154114 2005-05-26
JP2005-154114 2005-05-26
PCT/JP2006/310835 WO2006126723A1 (ja) 2005-05-26 2006-05-24 遺伝子組換え微生物およびそれらの微生物を用いるマクロライド系化合物の製造方法

Publications (2)

Publication Number Publication Date
AU2006250304A1 AU2006250304A1 (en) 2006-11-30
AU2006250304B2 true AU2006250304B2 (en) 2010-12-09

Family

ID=37452135

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006250304A Ceased AU2006250304B2 (en) 2005-05-26 2006-05-24 Genetically modified microorganism and process for production of macrolide compound using the microorganism

Country Status (15)

Country Link
US (1) US20090215134A1 (cg-RX-API-DMAC7.html)
EP (1) EP1911843B1 (cg-RX-API-DMAC7.html)
JP (1) JPWO2006126723A1 (cg-RX-API-DMAC7.html)
KR (1) KR20080012845A (cg-RX-API-DMAC7.html)
CN (1) CN101184838B (cg-RX-API-DMAC7.html)
AU (1) AU2006250304B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0610145A2 (cg-RX-API-DMAC7.html)
CA (1) CA2608841A1 (cg-RX-API-DMAC7.html)
IL (1) IL187081A0 (cg-RX-API-DMAC7.html)
NO (1) NO20075911L (cg-RX-API-DMAC7.html)
NZ (1) NZ562921A (cg-RX-API-DMAC7.html)
RU (1) RU2394906C2 (cg-RX-API-DMAC7.html)
SG (1) SG148168A1 (cg-RX-API-DMAC7.html)
TW (1) TW200716744A (cg-RX-API-DMAC7.html)
WO (1) WO2006126723A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005265443B2 (en) * 2004-07-20 2008-09-04 Eisai R & D Management Co., Ltd DNA coding for polypeptide participating in biosynthesis of pladienolide
CN102010403A (zh) 2005-10-13 2011-04-13 卫材R&D管理有限公司 普拉二烯内酯b和普拉二烯内酯d的全合成
CN101730693A (zh) 2007-07-06 2010-06-09 卫材R&D管理有限公司 大环内酯系化合物的制造方法及其制造中间体
JP5524053B2 (ja) * 2008-06-04 2014-06-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハーボキシジエンの生合成に関与するポリペプチドをコードするｄｎａ
CN107074827B (zh) * 2014-05-15 2020-12-18 卫材研究发展管理有限公司 普拉二烯内酯吡啶化合物和使用方法
SG11201803519YA (en) 2015-11-18 2018-06-28 Eisai R&D Man Co Ltd A solid state form of pladienolide pyridine compounds and methods of use
CN110408643B (zh) * 2018-11-30 2023-08-22 云南大学 一种提高自溶链霉菌洋橄榄叶素及其衍生物产量的方法
CN115247179B (zh) * 2021-04-25 2024-03-12 上海健康医学院 一种聚酮化合物骨架及其后修饰物的生物合成基因簇及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052152A1 (ja) * 2003-11-27 2005-06-09 Mercian Corporation マクロライド系化合物の水酸化に関与するｄｎａ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
JP2002526114A (ja) * 1998-10-02 2002-08-20 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドシンターゼおよびその組換えｄｎａ構築物
TWI312681B (en) * 2001-02-01 2009-08-01 Novel physiologically active substance
RU2372404C2 (ru) * 2001-10-19 2009-11-10 Сумитомо Кемикал Компани, Лимитед Метаболизирующий гербицид белок, его ген и их применение
EP1500704B1 (en) * 2002-04-12 2009-03-25 Mercian Corporation Expression system of actinomycete-origin cytochrome p-450 in escherichia coli
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
US7256178B2 (en) * 2002-07-31 2007-08-14 Eisai Co., Ltd. Physiologically active substances
EP1541570A4 (en) * 2002-07-31 2008-05-21 Mercian Corp NEW PHYSIOLOGICALLY EFFECTIVE SUBSTANCE
RU2330069C2 (ru) * 2002-11-29 2008-07-27 Мершан Корпорейшн Способ получения макролидного соединения и штаммы streptomyces sp., mortierella sp. и micromonosporaceae
CA2453080C (en) * 2003-01-21 2006-02-21 Ecopia Biosciences Inc. Polyene polyketides, processes for their production and their use as a pharmaceutical
AU2005265443B2 (en) * 2004-07-20 2008-09-04 Eisai R & D Management Co., Ltd DNA coding for polypeptide participating in biosynthesis of pladienolide
RU2327486C1 (ru) * 2007-07-04 2008-06-27 Валентина Васильевна Малиновская Лекарственное средство для лечения инфекционно-воспалительных заболеваний, обладающее иммуномодулирующим, антивирусным, антибактериальным, антиоксидантным, мембраностабилизирующим, противовоспалительным, антитоксическим свойствами

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052152A1 (ja) * 2003-11-27 2005-06-09 Mercian Corporation マクロライド系化合物の水酸化に関与するｄｎａ

Also Published As

Publication number Publication date
BRPI0610145A2 (pt) 2010-06-01
WO2006126723A1 (ja) 2006-11-30
CA2608841A1 (en) 2006-11-30
JPWO2006126723A1 (ja) 2008-12-25
CN101184838B (zh) 2011-06-15
SG148168A1 (en) 2008-12-31
IL187081A0 (cg-RX-API-DMAC7.html) 2008-02-09
KR20080012845A (ko) 2008-02-12
RU2394906C2 (ru) 2010-07-20
TW200716744A (en) 2007-05-01
EP1911843B1 (en) 2012-03-14
RU2007148928A (ru) 2009-07-10
NO20075911L (no) 2008-02-26
NZ562921A (en) 2009-06-26
US20090215134A1 (en) 2009-08-27
EP1911843A4 (en) 2009-01-07
AU2006250304A1 (en) 2006-11-30
EP1911843A1 (en) 2008-04-16
CN101184838A (zh) 2008-05-21

Similar Documents

Publication Publication Date Title
Kang et al. Biosynthesis of 3, 5-AHBA-derived natural products
EP1770165B1 (en) Dna coding for polypeptide participating in biosynthesis of pladienolide
Qu et al. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor
AU2006250304B2 (en) Genetically modified microorganism and process for production of macrolide compound using the microorganism
EP2192171B1 (en) Method for production of non-natural antibiotic
CN102906258B (zh) 酮还原酶突变体
EP1149919B1 (en) Genes related to biosynthesis of ML-236B
US8512995B2 (en) DNA encoding polypeptide involved in biosynthesis of herboxidiene
HK1120826A (en) Genetically modified microorganism and process for production of macrolide compound using the microorganism
EP1370578A1 (en) Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening
Jiang et al. Genetic engineering ofSorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis
JP2004173537A (ja) カナマイシン生合成遺伝子
EP1133562A1 (en) The gene cluster involved in aclacinomycin biosynthesis, and its use for genetic engineering
JP2006141294A (ja) 新規水酸化酵素、該酵素をコードするｄｎａおよびその利用
AU2002240981A1 (en) Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: EISAI R & D MANAGEMENT CO., LTD.; MICROBIOPHARM JA

Free format text: FORMER OWNER WAS: EISAI R & D MANAGEMENT CO., LTD.; MERCIAN CORPORATION

MK14 Patent ceased section 143(a) (annual fees not paid) or expired