RU2374246C2 - N-{2-[4-АМИНО-2-(ЭТОКСИМЕТИЛ)-1Н-ИМИДАЗО-[4,5-с]-ХИНОЛИН-1-ИЛ]-1,1-ДИМЕТИЛЭТИЛ}-МЕТАНСУЛЬФОНАМИД И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ - Google Patents
N-{2-[4-АМИНО-2-(ЭТОКСИМЕТИЛ)-1Н-ИМИДАЗО-[4,5-с]-ХИНОЛИН-1-ИЛ]-1,1-ДИМЕТИЛЭТИЛ}-МЕТАНСУЛЬФОНАМИД И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ Download PDFInfo
- Publication number
- RU2374246C2 RU2374246C2 RU2005138915/04A RU2005138915A RU2374246C2 RU 2374246 C2 RU2374246 C2 RU 2374246C2 RU 2005138915/04 A RU2005138915/04 A RU 2005138915/04A RU 2005138915 A RU2005138915 A RU 2005138915A RU 2374246 C2 RU2374246 C2 RU 2374246C2
- Authority
- RU
- Russia
- Prior art keywords
- imidazo
- quinolin
- amino
- butyl
- mmol
- Prior art date
Links
- NAKYGPHKOSYEKG-UHFFFAOYSA-N CCCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCNS(c1cccc2c1cccc2N(C)C)(=O)=O Chemical compound CCCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCNS(c1cccc2c1cccc2N(C)C)(=O)=O NAKYGPHKOSYEKG-UHFFFAOYSA-N 0.000 description 1
- NPUKURXYLSVTBZ-UHFFFAOYSA-N COCCc1nc(c(N)nc2c3CCCC2)c3[n]1CCCNS(C)(=O)=O Chemical compound COCCc1nc(c(N)nc2c3CCCC2)c3[n]1CCCNS(C)(=O)=O NPUKURXYLSVTBZ-UHFFFAOYSA-N 0.000 description 1
- SWHIFWUDVCHWMQ-UHFFFAOYSA-N COCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCCCCCCCS(c1ccccc1)(=O)=O Chemical compound COCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCCCCCCCS(c1ccccc1)(=O)=O SWHIFWUDVCHWMQ-UHFFFAOYSA-N 0.000 description 1
- XKWXZYMYHSFUJW-UHFFFAOYSA-N Cc(cc1)ccc1S(NCCC[n]1c2c(cccc3)c3nc(N)c2nc1CCOC)(=O)=O Chemical compound Cc(cc1)ccc1S(NCCC[n]1c2c(cccc3)c3nc(N)c2nc1CCOC)(=O)=O XKWXZYMYHSFUJW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48320003P | 2003-06-27 | 2003-06-27 | |
| US60/483,200 | 2003-06-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005138915A RU2005138915A (ru) | 2006-06-27 |
| RU2374246C2 true RU2374246C2 (ru) | 2009-11-27 |
Family
ID=33563911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005138915/04A RU2374246C2 (ru) | 2003-06-27 | 2004-06-25 | N-{2-[4-АМИНО-2-(ЭТОКСИМЕТИЛ)-1Н-ИМИДАЗО-[4,5-с]-ХИНОЛИН-1-ИЛ]-1,1-ДИМЕТИЛЭТИЛ}-МЕТАНСУЛЬФОНАМИД И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1638566A4 (zh) |
| JP (1) | JP2007521280A (zh) |
| KR (1) | KR20060035637A (zh) |
| CN (1) | CN1812789B (zh) |
| AR (2) | AR044923A1 (zh) |
| AU (1) | AU2004253929A1 (zh) |
| BR (1) | BRPI0411916A (zh) |
| CA (1) | CA2529322A1 (zh) |
| IL (1) | IL172427A0 (zh) |
| MX (1) | MXPA06000144A (zh) |
| MY (1) | MY157827A (zh) |
| NZ (1) | NZ544330A (zh) |
| RU (1) | RU2374246C2 (zh) |
| TW (2) | TW200514784A (zh) |
| WO (2) | WO2005003065A2 (zh) |
| ZA (1) | ZA200600769B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11279684B2 (en) | 2017-09-06 | 2022-03-22 | Bointech SE | Substituted imidazoquinolines as agonists of TLR7 |
| RU2773516C2 (ru) * | 2017-03-10 | 2022-06-06 | Пфайзер Инк. | Новые производные имидазо[4,5-с]хинолина в качестве ингибиторов LRRK2 |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| TW200510412A (en) | 2003-08-12 | 2005-03-16 | 3M Innovative Properties Co | Oxime substituted imidazo-containing compounds |
| CA2536136C (en) | 2003-08-27 | 2012-10-30 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| EP1660026A4 (en) | 2003-09-05 | 2008-07-16 | 3M Innovative Properties Co | TREATMENT FOR CD5 + B CELL LYMPHOMA |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| ES2584863T3 (es) | 2003-10-03 | 2016-09-29 | 3M Innovative Properties Company | Pirazolopiridinas y análogos de las mismas |
| RU2412942C2 (ru) | 2003-10-03 | 2011-02-27 | 3М Инновейтив Пропертиз Компани | Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов |
| US8598192B2 (en) | 2003-11-14 | 2013-12-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazoquinolines |
| EP1685129A4 (en) | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | OXIMSUBSTITUTED IMIDAZORING CONNECTIONS |
| KR101130928B1 (ko) | 2003-11-25 | 2012-04-12 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 치환된 이미다조 고리 시스템 및 방법 |
| JP2007513165A (ja) * | 2003-12-02 | 2007-05-24 | スリーエム イノベイティブ プロパティズ カンパニー | Ｉｒｍ化合物を含む併用薬および治療方法 |
| US8802853B2 (en) | 2003-12-29 | 2014-08-12 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| WO2005066169A2 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
| TW200612932A (en) | 2004-03-24 | 2006-05-01 | 3M Innovative Properties Co | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| US7897609B2 (en) | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| WO2006083440A2 (en) | 2004-12-30 | 2006-08-10 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| AU2005323024A1 (en) * | 2004-12-30 | 2006-07-13 | 3M Innovative Properties Company | Multi-route administration of immune response modifier compounds |
| ES2392647T3 (es) | 2004-12-30 | 2012-12-12 | 3M Innovative Properties Company | Compuestos tetracíclicos quirales que inducen la biosíntesis de interferón |
| CA2597092A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| US20080318998A1 (en) | 2005-02-09 | 2008-12-25 | Coley Pharmaceutical Group, Inc. | Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines |
| AU2006213746A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
| CA2602683A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| CA2602590A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| CN101300254A (zh) * | 2005-09-09 | 2008-11-05 | 科利制药集团公司 | N－{2－[4－氨基－2－(乙氧基甲基)－1H－咪唑并[4,5－c]喹啉－1－基]－1,1－二甲基乙基}甲磺酰胺的酰胺和氨基甲酸酯衍生物和方法 |
| EA014244B1 (ru) * | 2005-09-23 | 2010-10-29 | Коли Фармасьютикал Груп, Инк. | СПОСОБ ПОЛУЧЕНИЯ 1-Н-ИМИДАЗО[4,5-c]ПИРИДИНОВ И ИХ АНАЛОГОВ |
| US8951528B2 (en) | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| US7906506B2 (en) | 2006-07-12 | 2011-03-15 | 3M Innovative Properties Company | Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods |
| DK2386557T3 (en) * | 2008-03-24 | 2018-04-23 | Biontech Ag | Newly substituted imidazoquinolines |
| EP3222621B1 (en) | 2010-08-17 | 2023-03-08 | 3M Innovative Properties Company | Lipidated immune response modifier compound and its medical use |
| CN103582496B (zh) | 2011-06-03 | 2016-05-11 | 3M创新有限公司 | 具有聚乙二醇链段的异双官能连接基以及由其制成的免疫应答调节剂缀合物 |
| MX355623B (es) | 2011-06-03 | 2018-04-25 | 3M Innovative Properties Co | Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. |
| US9695171B2 (en) | 2013-12-17 | 2017-07-04 | Pfizer Inc. | 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors |
| AU2016322813B2 (en) | 2015-09-14 | 2021-04-01 | Pfizer Inc. | Novel imidazo (4,5-c) quinoline and imidazo (4,5-c)(1,5) naphthyridine derivatives as LRRK2 inhibitors |
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| AU2018230236B2 (en) | 2017-03-10 | 2022-05-19 | Pfizer Inc. | Novel imidazo[4,5-c]quinoline derivatives as LRRK2 inhibitors |
| WO2019123178A1 (en) | 2017-12-20 | 2019-06-27 | 3M Innovative Properties Company | Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier |
| JP2022525594A (ja) | 2019-03-15 | 2022-05-18 | ボルト バイオセラピューティクス、インコーポレーテッド | Ｈｅｒ２を標的とする免疫結合体 |
| EP4076445A1 (en) * | 2019-12-20 | 2022-10-26 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| EP1455700A4 (en) * | 2001-11-16 | 2007-02-14 | 3M Innovative Properties Co | METHODS AND COMPOSITIONS RELATED TO MRI COMPOUNDS AND TO TOLL-TYPE RECEPTOR (TLR) PATHWAYS |
| US6677349B1 (en) * | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
-
2004
- 2004-06-24 MY MYPI20042461A patent/MY157827A/en unknown
- 2004-06-25 WO PCT/US2004/020607 patent/WO2005003065A2/en active Application Filing
- 2004-06-25 AR ARP040102248A patent/AR044923A1/es unknown
- 2004-06-25 KR KR1020057024904A patent/KR20060035637A/ko not_active Application Discontinuation
- 2004-06-25 AR ARP040102247A patent/AR044922A1/es unknown
- 2004-06-25 WO PCT/US2004/020606 patent/WO2005003064A2/en not_active Application Discontinuation
- 2004-06-25 BR BRPI0411916-9A patent/BRPI0411916A/pt not_active IP Right Cessation
- 2004-06-25 CA CA002529322A patent/CA2529322A1/en not_active Abandoned
- 2004-06-25 RU RU2005138915/04A patent/RU2374246C2/ru not_active IP Right Cessation
- 2004-06-25 AU AU2004253929A patent/AU2004253929A1/en not_active Abandoned
- 2004-06-25 NZ NZ544330A patent/NZ544330A/en unknown
- 2004-06-25 MX MXPA06000144A patent/MXPA06000144A/es unknown
- 2004-06-25 EP EP04756208A patent/EP1638566A4/en not_active Withdrawn
- 2004-06-25 JP JP2006517711A patent/JP2007521280A/ja active Pending
- 2004-06-25 CN CN2004800181459A patent/CN1812789B/zh not_active Expired - Fee Related
- 2004-06-25 TW TW093118635A patent/TW200514784A/zh unknown
- 2004-06-25 TW TW093118636A patent/TW200511992A/zh unknown
-
2005
- 2005-12-07 IL IL172427A patent/IL172427A0/en unknown
-
2006
- 2006-01-26 ZA ZA200600769A patent/ZA200600769B/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2773516C2 (ru) * | 2017-03-10 | 2022-06-06 | Пфайзер Инк. | Новые производные имидазо[4,5-с]хинолина в качестве ингибиторов LRRK2 |
| US11279684B2 (en) | 2017-09-06 | 2022-03-22 | Bointech SE | Substituted imidazoquinolines as agonists of TLR7 |
| RU2776748C2 (ru) * | 2017-09-06 | 2022-07-26 | Бионтех Се | Замещенные имидазохинолины в качестве агонистов tlr7 |
| US11987569B2 (en) | 2017-09-06 | 2024-05-21 | BioNTech SE | Substituted imidazoquinolines as agonists of TLR7 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1812789B (zh) | 2010-07-14 |
| WO2005003064A3 (en) | 2005-03-31 |
| AU2004253929A1 (en) | 2005-01-13 |
| TW200514784A (en) | 2005-05-01 |
| JP2007521280A (ja) | 2007-08-02 |
| NZ544330A (en) | 2009-06-26 |
| WO2005003065A2 (en) | 2005-01-13 |
| BRPI0411916A (pt) | 2006-08-15 |
| KR20060035637A (ko) | 2006-04-26 |
| EP1638566A2 (en) | 2006-03-29 |
| TW200511992A (en) | 2005-04-01 |
| MXPA06000144A (es) | 2006-04-07 |
| AR044922A1 (es) | 2005-10-12 |
| CN1812789A (zh) | 2006-08-02 |
| WO2005003065A3 (en) | 2005-03-10 |
| AR044923A1 (es) | 2005-10-12 |
| EP1638566A4 (en) | 2009-03-25 |
| MY157827A (en) | 2016-07-29 |
| WO2005003064A2 (en) | 2005-01-13 |
| ZA200600769B (en) | 2007-05-30 |
| CA2529322A1 (en) | 2005-01-13 |
| RU2005138915A (ru) | 2006-06-27 |
| IL172427A0 (en) | 2006-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110626 |