RU2348413C2 - Противоопухолевые лекарственные составы, содержащие дефибротид, один или в сочетании с другими противоопухолевыми средствами - Google Patents

Противоопухолевые лекарственные составы, содержащие дефибротид, один или в сочетании с другими противоопухолевыми средствами Download PDF

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Publication number
RU2348413C2
RU2348413C2 RU2006109210/15A RU2006109210A RU2348413C2 RU 2348413 C2 RU2348413 C2 RU 2348413C2 RU 2006109210/15 A RU2006109210/15 A RU 2006109210/15A RU 2006109210 A RU2006109210 A RU 2006109210A RU 2348413 C2 RU2348413 C2 RU 2348413C2
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RU
Russia
Prior art keywords
defibrotide
tumor
mammary gland
active ingredient
bcnu
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RU2006109210/15A
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English (en)
Russian (ru)
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RU2006109210A (ru
Inventor
Лаура Ирис ФЕРРО (IT)
Лаура Ирис Ферро
Массимо ИАКОБЕЛЛИ (IT)
Массимо ИАКОБЕЛЛИ
Пол РИЧАРДСОН (US)
Пол Ричардсон
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Гентиум С.П.А. (It/It)
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Publication of RU2006109210A publication Critical patent/RU2006109210A/ru
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Publication of RU2348413C2 publication Critical patent/RU2348413C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2006109210/15A 2003-09-05 2004-08-27 Противоопухолевые лекарственные составы, содержащие дефибротид, один или в сочетании с другими противоопухолевыми средствами RU2348413C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT001714A ITMI20031714A1 (it) 2003-09-05 2003-09-05 Formazioni ad azione antitumorale.
ITMI2003A001714 2003-09-05
US53934404P 2004-01-28 2004-01-28
US60/539,344 2004-01-28

Publications (2)

Publication Number Publication Date
RU2006109210A RU2006109210A (ru) 2007-10-10
RU2348413C2 true RU2348413C2 (ru) 2009-03-10

Family

ID=37064585

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006109210/15A RU2348413C2 (ru) 2003-09-05 2004-08-27 Противоопухолевые лекарственные составы, содержащие дефибротид, один или в сочетании с другими противоопухолевыми средствами

Country Status (23)

Country Link
US (2) US8551967B2 (cg-RX-API-DMAC7.html)
EP (1) EP1660100B1 (cg-RX-API-DMAC7.html)
JP (1) JP4671962B2 (cg-RX-API-DMAC7.html)
KR (1) KR20060061367A (cg-RX-API-DMAC7.html)
CN (1) CN100490820C (cg-RX-API-DMAC7.html)
AT (1) ATE399558T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004269896B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0414114A (cg-RX-API-DMAC7.html)
CA (1) CA2537226C (cg-RX-API-DMAC7.html)
DE (1) DE602004014787D1 (cg-RX-API-DMAC7.html)
DK (1) DK1660100T3 (cg-RX-API-DMAC7.html)
ES (1) ES2308223T3 (cg-RX-API-DMAC7.html)
IL (1) IL173785A0 (cg-RX-API-DMAC7.html)
IS (1) IS8334A (cg-RX-API-DMAC7.html)
IT (1) ITMI20031714A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06002489A (cg-RX-API-DMAC7.html)
NO (1) NO20061402L (cg-RX-API-DMAC7.html)
PT (1) PT1660100E (cg-RX-API-DMAC7.html)
RS (1) RS20060154A (cg-RX-API-DMAC7.html)
RU (1) RU2348413C2 (cg-RX-API-DMAC7.html)
UA (1) UA83500C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005023273A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200601852B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2729628C2 (ru) * 2014-11-27 2020-08-11 Джентиум С.Р.Л. Клеточный способ определения эффективности дефибротида

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2598613A1 (en) * 2005-03-03 2006-09-14 Gentium S.P.A. Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors
EP1872787A1 (en) * 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
CN103260627A (zh) 2010-11-12 2013-08-21 真蒂奥姆有限公司 去纤维蛋白多核苷酸用于预防和/或治疗移植物抗宿主病(gvhd)
AU2012383169B2 (en) 2012-06-22 2017-12-21 Gentium S.R.L. Euglobulin-based method for determining the biological activity of defibrotide
US10380734B2 (en) * 2017-02-27 2019-08-13 Aniket Bharat Parikh System, method and computer program product for security analysis of jewelry items
SG11202000952PA (en) * 2017-08-03 2020-02-27 Jazz Pharmaceuticals Ireland Ltd Formulations comprising a nucleic acid in a high concentration
KR20210008478A (ko) 2018-04-12 2021-01-22 재즈 파마슈티칼즈, 인코포레이티드 면역고갈과 관련된 사이토카인 방출 증후군 및 신경독성의 예방 및 치료를 위한 데피브로타이드
US20220023533A1 (en) 2018-12-07 2022-01-27 Jazz Phrmaceticals Ireland Limited Subcutaneous delivery of high concentration formulations
EP4110287A1 (en) 2020-02-28 2023-01-04 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
TW202308659A (zh) 2021-05-06 2023-03-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693995A (en) * 1984-02-16 1987-09-15 Crinos Industria Farmacobiologica S.P.A. Pharmaceutical composition for the treatment of acute myocardial ischemia

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
US4694134A (en) * 1985-05-28 1987-09-15 Ajax Magnethermic Corporation Apparatus for overheating edges of skelp for the production of compression welded pipe
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
US5223609A (en) * 1986-04-17 1993-06-29 Crinos Industria Farmacobiologica S.P.A. Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
US6699985B2 (en) * 1991-08-21 2004-03-02 Arsinur Burcoglu Method of treating HIV infection and related secondary infections thereof
US5977083A (en) * 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
IT1252174B (it) * 1991-12-09 1995-06-05 Crinos Industria Farmaco Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
DE9202745U1 (de) 1992-03-02 1992-04-30 Howmedica Gmbh, 2314 Schoenkirchen Vorrichtung zum Verspannen von Wirbeln der menschlichen Wirbelsäule
US5578716A (en) * 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
HK1044896A1 (zh) * 1997-04-28 2002-11-08 Burcoglu Arsinur 治疗hiv感染和与之有关的继发感染的方法
WO1998054313A2 (en) 1997-05-30 1998-12-03 Mcgill University Dna methyltransferase genomic sequences and antisense oligonucleotides
US6177545B1 (en) 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
DE19740384A1 (de) 1997-09-08 1999-03-11 Max Delbrueck Centrum Antisense Oligodesoxynukleotide (ODN) gegen Proteinkinase C (PKC)-Isoformen, ihre Verwendung und pharmazeutische Zubereitungen dieser ODN
WO2000074634A2 (en) * 1999-06-03 2000-12-14 Au Jessie L S Methods and compositions for modulating cell proliferation and cell death
CA2433225A1 (en) * 2000-12-29 2002-07-11 Bio-Technology General, Inc. Isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US6770753B2 (en) 2001-07-05 2004-08-03 The Trustees Of Columbia University In The City Of New York Phosphorothioate antisense heparanase oligonucleotides
WO2003027313A2 (en) 2001-09-24 2003-04-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
US20050032882A1 (en) * 2002-03-06 2005-02-10 Sophie Chen Botanical extract compositions and methods of use
AU2003238189A1 (en) * 2002-05-31 2003-12-19 Klinikum Der Universitat Regensburg Method for the protection of endothelial and epithelial cells during chemotherapy
BR0312483A (pt) * 2002-07-01 2005-08-09 Savient Pharmaceuticals Inc Anticorpos e seus usos
AU2003252395A1 (en) 2002-08-06 2004-03-11 Toray Industries, Inc. Remedy or preventive for kidney disease and method of diagnosing kidney disease
DE10244453A1 (de) 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
CA2598613A1 (en) 2005-03-03 2006-09-14 Gentium S.P.A. Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors
EP1872787A1 (en) 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693995A (en) * 1984-02-16 1987-09-15 Crinos Industria Farmacobiologica S.P.A. Pharmaceutical composition for the treatment of acute myocardial ischemia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EISSNER G, Blood. 2002 Jul 1; 100(1):334-40, Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide, реферат, PMID: 12070045. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2729628C2 (ru) * 2014-11-27 2020-08-11 Джентиум С.Р.Л. Клеточный способ определения эффективности дефибротида

Also Published As

Publication number Publication date
RU2006109210A (ru) 2007-10-10
PT1660100E (pt) 2008-10-14
CN100490820C (zh) 2009-05-27
ITMI20031714A1 (it) 2005-03-06
ES2308223T3 (es) 2008-12-01
KR20060061367A (ko) 2006-06-07
NO20061402L (no) 2006-03-28
ATE399558T1 (de) 2008-07-15
AU2004269896A1 (en) 2005-03-17
DK1660100T3 (da) 2008-11-10
ZA200601852B (en) 2007-06-27
US20140005256A1 (en) 2014-01-02
MXPA06002489A (es) 2006-06-20
US8551967B2 (en) 2013-10-08
IS8334A (is) 2006-02-28
RS20060154A (sr) 2008-08-07
JP2007504194A (ja) 2007-03-01
IL173785A0 (en) 2006-07-05
JP4671962B2 (ja) 2011-04-20
AU2004269896B2 (en) 2009-11-19
WO2005023273A1 (en) 2005-03-17
CA2537226C (en) 2016-05-03
BRPI0414114A (pt) 2006-10-31
EP1660100B1 (en) 2008-07-02
US20060211646A1 (en) 2006-09-21
EP1660100A1 (en) 2006-05-31
UA83500C2 (uk) 2008-07-25
CN1845746A (zh) 2006-10-11
DE602004014787D1 (de) 2008-08-14
CA2537226A1 (en) 2005-03-17

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Effective date: 20090828