RU2344134C2 - 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов - Google Patents

1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов Download PDF

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Publication number
RU2344134C2
RU2344134C2 RU2007107408/04A RU2007107408A RU2344134C2 RU 2344134 C2 RU2344134 C2 RU 2344134C2 RU 2007107408/04 A RU2007107408/04 A RU 2007107408/04A RU 2007107408 A RU2007107408 A RU 2007107408A RU 2344134 C2 RU2344134 C2 RU 2344134C2
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RU
Russia
Prior art keywords
ethyl
dipyridin
mixture
mmol
alkyl
Prior art date
Application number
RU2007107408/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2007107408A (ru
Inventor
Марк Т. БИЛОДО (US)
Марк Т. БИЛОДО
Чжицай У. (US)
Чжицай У.
Джон ХАРТНЕТТ (US)
Джон Хартнетт
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of RU2007107408A publication Critical patent/RU2007107408A/ru
Application granted granted Critical
Publication of RU2344134C2 publication Critical patent/RU2344134C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2007107408/04A 2004-07-29 2005-07-25 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов RU2344134C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59218104P 2004-07-29 2004-07-29
US60/592,181 2004-07-29

Publications (2)

Publication Number Publication Date
RU2007107408A RU2007107408A (ru) 2008-09-10
RU2344134C2 true RU2344134C2 (ru) 2009-01-20

Family

ID=35613661

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007107408/04A RU2344134C2 (ru) 2004-07-29 2005-07-25 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов

Country Status (15)

Country Link
KR (1) KR20070043985A (fr)
AR (1) AR049847A1 (fr)
BR (1) BRPI0513793A (fr)
CR (1) CR8876A (fr)
EC (1) ECSP077208A (fr)
IL (1) IL180846A0 (fr)
MA (1) MA28980B1 (fr)
MX (1) MX2007001188A (fr)
NO (1) NO20071107L (fr)
PE (1) PE20060382A1 (fr)
RU (1) RU2344134C2 (fr)
TW (1) TW200607493A (fr)
UA (1) UA88018C2 (fr)
WO (1) WO2006028590A1 (fr)
ZA (1) ZA200700477B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539398C2 (ru) * 2009-03-18 2015-01-20 Медикю Интернэшинал Инк. Трансдермальный фармацевтический препарат и введение тирофибана

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014030629B1 (pt) 2012-06-11 2021-12-21 Bristol-Myers Squibb Company Prófármacos de ácido fosforamídico de 5-[5-fenil-4-(piridin-2-ilmetilamino) quinazolin -2-il] piridina-3-sulfonamida e composição farmacêutica que os compreende

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059873A1 (fr) * 2002-01-04 2003-07-24 Poseidon Pharmaceuticals A/S Modulateurs de canaux de potassium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STEEL P.J. et al. Coordination chemistry of di-2-pyridylmethane and related bridging ligands with silver …", Dalton transactions., no. 23, 2003, p.4505-4515. D′Alessandro, D.M. et all. Mono- and di-nuclear complexes of the ligands 3,4-di(2-pyridyl)-1,2,5-oxadiazole and 3,4-di(2-pyridyl)-1,2,5-thiadiazole; …). AUSTRALIAN JOURNAL OF CHEMISTRY. Vol.56, no. 7, 2003, pages 657-664. R. HABERL et al. 1,2-di-.alphy.-pyridyl-1,2-diphenylethane. MONATSHEFTE FUER CHEMIE. Vol.88, 1957, p.47-51. W.CZUBA. Effects of substituent groups on the rearrangement of 3-nitroaminopyridine derivatives. BULLETIN DE L′ACADEMIE POLONAISE DES SCIENCES. Vol.8, no. 6, 1960, p.281-284. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539398C2 (ru) * 2009-03-18 2015-01-20 Медикю Интернэшинал Инк. Трансдермальный фармацевтический препарат и введение тирофибана

Also Published As

Publication number Publication date
RU2007107408A (ru) 2008-09-10
BRPI0513793A (pt) 2008-05-13
UA88018C2 (ru) 2009-09-10
AR049847A1 (es) 2006-09-06
MX2007001188A (es) 2007-03-21
KR20070043985A (ko) 2007-04-26
PE20060382A1 (es) 2006-05-15
WO2006028590A1 (fr) 2006-03-16
CR8876A (es) 2007-08-28
ZA200700477B (en) 2009-08-26
IL180846A0 (en) 2007-06-03
MA28980B1 (fr) 2007-11-01
TW200607493A (en) 2006-03-01
ECSP077208A (es) 2007-02-28
NO20071107L (no) 2007-04-19

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20100726