RU2332211C2 - Стабильные композиции аторвастатина, получаемые влажным гранулированием - Google Patents

Стабильные композиции аторвастатина, получаемые влажным гранулированием Download PDF

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Publication number
RU2332211C2
RU2332211C2 RU2005136745/15A RU2005136745A RU2332211C2 RU 2332211 C2 RU2332211 C2 RU 2332211C2 RU 2005136745/15 A RU2005136745/15 A RU 2005136745/15A RU 2005136745 A RU2005136745 A RU 2005136745A RU 2332211 C2 RU2332211 C2 RU 2332211C2
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RU
Russia
Prior art keywords
atorvastatin
granules
composition
wet
grinding
Prior art date
Application number
RU2005136745/15A
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English (en)
Russian (ru)
Other versions
RU2005136745A (ru
Inventor
Кеннет Крейг УОТЕРМАН (US)
Кеннет Крейг УОТЕРМАН
Майкл Брюс ФЕРДЖИОНЕ (US)
Майкл Брюс ФЕРДЖИОНЕ
Барбара Элис ДЖОНСОН (US)
Барбара Элис ДЖОНСОН
Original Assignee
УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of RU2005136745A publication Critical patent/RU2005136745A/ru
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Publication of RU2332211C2 publication Critical patent/RU2332211C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
RU2005136745/15A 2003-06-12 2004-06-01 Стабильные композиции аторвастатина, получаемые влажным гранулированием RU2332211C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47811903P 2003-06-12 2003-06-12
US60/478,119 2003-06-12

Publications (2)

Publication Number Publication Date
RU2005136745A RU2005136745A (ru) 2006-07-27
RU2332211C2 true RU2332211C2 (ru) 2008-08-27

Family

ID=33551806

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005136745/15A RU2332211C2 (ru) 2003-06-12 2004-06-01 Стабильные композиции аторвастатина, получаемые влажным гранулированием

Country Status (15)

Country Link
EP (1) EP1635814A1 (fr)
JP (1) JP2006527260A (fr)
KR (1) KR100814218B1 (fr)
CN (1) CN100434069C (fr)
AR (1) AR044774A1 (fr)
AU (1) AU2004246868B2 (fr)
BR (1) BRPI0411344A (fr)
CA (1) CA2465565A1 (fr)
CO (1) CO5650230A2 (fr)
MX (1) MXPA05013281A (fr)
NO (1) NO20060022L (fr)
NZ (1) NZ543337A (fr)
RU (1) RU2332211C2 (fr)
TW (1) TW200503690A (fr)
WO (1) WO2004110431A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
CA2691956A1 (fr) * 2007-06-25 2008-12-31 Pharmathen S.A. Formulation pharmaceutique amelioree contenant un inhibiteur de la hmg-coa reductase et son procede de preparation
CA2716671A1 (fr) * 2008-02-27 2009-09-03 Thommen Medical Ag Implant et procede de fabrication
JP5714492B2 (ja) * 2008-09-17 2015-05-07 マイラン インコーポレイテッド 粒状体、それらの調製方法、およびそれらを含む医薬品
HUP1000299A2 (hu) 2010-06-08 2012-02-28 Nanoform Cardiovascular Therapeutics Ltd Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra
RU2014124118A (ru) 2011-11-15 2015-12-27 Др. Редди'С Лабораторис Лтд. Фармацевтические препараты, включающие аторвастатин и глимепирид
CN104069078B (zh) * 2014-05-22 2019-06-11 西藏九瑞健康股份有限公司 阿托伐他汀钙药物组合物及其制备方法
US10085993B2 (en) 2014-07-25 2018-10-02 Novartis Ag Tablet formulation of 2-fluoro-N-methyl-4-[ 7-( quinolin-6-ylmethyl) imidazo [1,2-B] [1,2,4] triazin-2-yl] benzamide
KR101658350B1 (ko) * 2015-02-06 2016-09-30 경성대학교 산학협력단 고지혈증 치료에 유용한 약학 조성물
WO2016145132A1 (fr) * 2015-03-12 2016-09-15 Fmc Corporation Dispersions solides
CN109152787A (zh) 2016-03-31 2019-01-04 英特塞普特医药品公司 具有优越的溶出性的口服制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016693A1 (fr) * 1993-01-19 1994-08-04 Warner-Lambert Company Formulation ci-981, orale, stable et son procede de preparation
JPH06242003A (ja) * 1993-02-12 1994-09-02 Nkk Corp 鉄鋼中のアルミナの粒度測定方法
JP3014040B2 (ja) * 1996-10-30 2000-02-28 信久 川野 食物繊維パン及びその製造法
ATE524163T1 (de) * 2000-04-10 2011-09-15 Teva Pharma Stabile pharmazeutische zusammensetzungen enthaltend 7-substituierte-3,5- dihydroxyheptansäuren oder 7-substituierte-3,5- dihydroxyheptensäuren
US6242003B1 (en) * 2000-04-13 2001-06-05 Novartis Ag Organic compounds
EP1226818A1 (fr) * 2001-01-26 2002-07-31 Pfizer Products Inc. Formulation pharmaceutique présentant des propriétés de cohesion et de compressibilité améliorées
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
КУДРИН А.Н. Проблемы взаимодействия лекарственных средств. Фармация №2, 1983, с.71-76. *

Also Published As

Publication number Publication date
KR20060020666A (ko) 2006-03-06
TW200503690A (en) 2005-02-01
AR044774A1 (es) 2005-10-05
NO20060022L (no) 2006-01-03
CN100434069C (zh) 2008-11-19
CO5650230A2 (es) 2006-06-30
KR100814218B1 (ko) 2008-03-17
AU2004246868A1 (en) 2004-12-23
WO2004110431A1 (fr) 2004-12-23
NZ543337A (en) 2008-03-28
CN1805741A (zh) 2006-07-19
CA2465565A1 (fr) 2004-12-12
BRPI0411344A (pt) 2006-07-11
MXPA05013281A (es) 2006-03-09
JP2006527260A (ja) 2006-11-30
RU2005136745A (ru) 2006-07-27
AU2004246868B2 (en) 2008-01-17
EP1635814A1 (fr) 2006-03-22

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20090602