RU2323732C1 - Methods of cattle actinomycosis treatment - Google Patents

Abstract

FIELD: agriculture; veterinary science.

SUBSTANCE: may be used when treating cow actinomycosis. The method consists in introduction of sodium hypochlorite intravenously 300 ml solution 600 mg/l and 100 ml in the concentration 300mg/l directly in the lesion focus at the 1^st stage within 5 days. At the 2^nd stage sodium hypochlorite 100 ml in the concentration 300 mg/l is introduced in the lesion focus within 5 days.

EFFECT: method allows accelerating treatment and preserving meat products quality.

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Description

The present invention relates to veterinary medicine and can be used in the treatment of cattle with actinomycosis.

The problem of treating actinomycosis remains quite relevant. This is due to the fact that the methods for the prevention and treatment of this disease over the past decades have not been improved. Known methods of treating this disease boil down to antibiotic therapy and surgical autopsy with actinomics. These methods are not perfect enough, as they are not always effective against pathogens of fungi of a number of Actinomyces. All this determines the relevance of developing more advanced methods of treating this pathology.

There is a method of treating actinomycosis by autohemotherapy in combination with antibiotics (penicillin, bicillin, tetracycline hydrochloride) (K.I.Shakalov and other Private veterinary surgery. - M., "Kolos", 1986).

The disadvantages of this method of treatment is that antibiotics have a low fungicidal effect on the animal organism, worsen the quality of meat and dairy products, this method is characterized by a long treatment.

There is also known a method of intravenous administration of a 10% solution of sodium iodide in a dose of 1 ml per 3 kg of animal weight every 24 hours for 3 days or the introduction of 40-80 ml of iodinol into the thickness of the actinomycom after 2-4 days, a total of 8- 12 injections (K.I.Shakalov and others. Private veterinary surgery. - M., Kolos, 1986), taken as the closest analogue.

The disadvantages of this method are the complexity, low therapeutic efficacy.

The technical solution to the problem is to increase the effectiveness of the treatment of actinomycosis by expanding the biological effect of drugs, reducing the complexity of the treatment process, eliminating the side effects of the drugs used on animals, improving the quality of dairy and meat products by eliminating side effects on animals, and reducing the cost of treatment.

The essence of the method lies in the fact that at the first stage, the animal is injected daily with sodium hypochlorite 300 ml of solution at a concentration of 600 mg / l intravenously for 5 days and directly into the lesion site at 100 ml at a concentration of 300 mg / l, and then at 2nd stage - only in the lesion focus, also within 5 days.

The technical result of the claimed proposal is due to the fact that sodium hypochlorite contains an active substance CLO (hypochlorite anion), which has a fungicidal and bactericidal effect, excludes the development of antibiotic-resistant strains of microorganisms, does not have a cumulative effect, during the use of the drug, products can be used without limitation on the implementation time. The indicated properties of sodium hypochlorite can improve the result of treatment, reduce the cost and duration of treatment, and eliminate side effects.

A method of treating actinomycosis in cattle is as follows.

Testing the therapeutic effectiveness of the proposed method using sodium hypochlorite was carried out on cattle of black-motley breed aged 5-6 years. For this, two groups of animals were formed with 10 animals each.

The animals of the first group were injected intravenously with sodium hypochlorite 300 ml each day for 5 days at a concentration of 600 mg / l and directly into the lesion 100 ml at a concentration of 300 mg / l, and then at the 2nd stage of treatment - only into the lesion (actinomic) also 100 ml at a concentration of 300 mg / l also for 5 days.

When testing the animals of the second group, the following treatment was prescribed: a 0.5% solution of novocaine with tetracycline hydrochloride was administered into and around the actinomycoma at a rate of 10 mg / kg body weight per injection 2 times a day for 12 days.

During the experiment, animals were clinically monitored, paying attention to the general condition of the animals, appetite, and the nature of healing by actinomics.

As a result of testing in animals of the first group, an improvement in general condition was noted already on the 3rd day from the start of treatment, the appetite was restored, the opened foci of inflammation decreased in volume, unopened actinomycomas were painless on palpation.

A significant improvement in the clinical condition in animals was noted on the 5-6th day from the start of treatment, complete recovery - on the 8-10th day.

In animals of the second group, an improvement in the clinical picture of the disease was noted on the 14-15th day from the start of treatment.

The drug is sodium hypochlorite. In order to clarify the mode of administration of Na hypochlorite and various time intervals of administration, testing was carried out on 3 groups of cows, 10 animals in each group.

The results of the various modes of administration of sodium hypochlorite are summarized in the table.

Table 1 Testing, gr. Duration of treatment (days) Treatment results one eighteen Recovery 2 14-15 Clinical improvement 3 12-13 Clinical improvement four 10 Recovery

Note: - Administration of sodium hypochlorite intravenously every other day 5 times, then also every other day 5 times directly into the focus of inflammation.

- Introduction of sodium hypochlorite intravenously every other day 5 times with the condition of administration to actinomycom on 2, 4, 6, 8 days.

- The introduction of sodium hypochlorite intravenously daily for 5 days, then daily for 5 days directly into the actinomy.

- Daily intravenous and mediocre introduction of sodium hypochlorite into the actinomic for five days, and then for 5 days only in the focus of inflammation.

The results of the treatment of the proposed method and basic (the use of antibiotics).

table 2 Indicators The proposed method Antibiotic tetracycline hydrochloride Duration of treatment (days) 8-10 days 14-15 days Side effects Are absent Dysbacteriosis, the formation of antibiotic-resistant strains of microorganisms Product quality Negatively does not affect product quality Use of products is possible 5-7 days after the end of the course of treatment Cost effectiveness 8-10 rubles per 1 rub. cost 3-5 rubles per 1 rub. cost Environmental Safety Environmentally friendly Environmentally hazardous

Example. Black-motley cow, 5 years old. 3 actinomycomas were found on the surface of the skin in the head region. The treatment was carried out in 2 stages. At the 1st stage, the animal was injected intravenously with sodium hypochlorite 300 ml at a concentration of 600 mg / L daily for 5 days and directly into actinomycoma at a concentration of 300 mg at 300 mg / L, and then at the 2nd stage only at the lesion site , also 100 ml at a concentration of 300 mg / l, also for 5 days. Clinical improvement was recorded already on the 3rd day from the start of treatment. The opened actinomycomas sprouted with granulation tissue 4-5 days after the start of treatment. On the 10th day from the start of treatment, the animal had a good clinical status, the appetite was preserved, and the actinomic healed completely.

Claims (1)

A method of treating actinomycosis in cattle, including drug exposure, characterized in that at the first stage, the animal is injected intravenously with sodium hypochlorite 300 ml of a solution at a concentration of 600.0 mg / l daily for 5 days and directly into actinomycosis 100.0 ml at a concentration of 300.0 mg / l of the same solution, and then at the 2nd stage - only at the lesion site, also at 100.0 ml at a concentration of 300.0 mg / l for 5 days.