RU2322971C2 - Фармацевтическая композиция, содержащая ингибитор гистондеацетилазы - Google Patents

Фармацевтическая композиция, содержащая ингибитор гистондеацетилазы Download PDF

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Publication number
RU2322971C2
RU2322971C2 RU2005140570/15A RU2005140570A RU2322971C2 RU 2322971 C2 RU2322971 C2 RU 2322971C2 RU 2005140570/15 A RU2005140570/15 A RU 2005140570/15A RU 2005140570 A RU2005140570 A RU 2005140570A RU 2322971 C2 RU2322971 C2 RU 2322971C2
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RU
Russia
Prior art keywords
ingredient
cancer
pharmaceutical combination
substance
combination according
Prior art date
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RU2005140570/15A
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English (en)
Russian (ru)
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RU2005140570A (ru
Inventor
Осаму НАКАНИСИ (JP)
Осаму НАКАНИСИ
Тацуо СУГАВАРА (JP)
Тацуо СУГАВАРА
Хидеюки МИГИТА (US)
Хидеюки МИГИТА
Ясухиро МАЦУБА (JP)
Ясухиро МАЦУБА
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Шеринг Акциенгезелльшафт
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Publication of RU2005140570A publication Critical patent/RU2005140570A/ru
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Publication of RU2322971C2 publication Critical patent/RU2322971C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
RU2005140570/15A 2003-05-26 2004-05-26 Фармацевтическая композиция, содержащая ингибитор гистондеацетилазы RU2322971C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-148073 2003-05-26
JP2003148073 2003-05-26

Publications (2)

Publication Number Publication Date
RU2005140570A RU2005140570A (ru) 2006-06-10
RU2322971C2 true RU2322971C2 (ru) 2008-04-27

Family

ID=33475383

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005140570/15A RU2322971C2 (ru) 2003-05-26 2004-05-26 Фармацевтическая композиция, содержащая ингибитор гистондеацетилазы

Country Status (27)

Country Link
US (1) US20070098816A1 (enExample)
EP (1) EP1626719A1 (enExample)
JP (1) JP2006526031A (enExample)
KR (1) KR100938712B1 (enExample)
CN (2) CN1794991A (enExample)
AR (1) AR045318A1 (enExample)
AU (1) AU2004241873C1 (enExample)
BR (1) BRPI0410959A (enExample)
CA (4) CA2634709A1 (enExample)
CL (1) CL2004001278A1 (enExample)
CO (1) CO5660262A2 (enExample)
CR (1) CR8163A (enExample)
CU (1) CU23490B7 (enExample)
EC (1) ECSP056253A (enExample)
IL (1) IL171941A0 (enExample)
ME (1) MEP32308A (enExample)
MX (1) MXPA05012345A (enExample)
NO (1) NO20055417L (enExample)
NZ (1) NZ543591A (enExample)
PE (1) PE20050206A1 (enExample)
RS (1) RS20050884A (enExample)
RU (1) RU2322971C2 (enExample)
TW (1) TW200505424A (enExample)
UA (1) UA81499C2 (enExample)
UY (1) UY28330A1 (enExample)
WO (1) WO2004103369A1 (enExample)
ZA (1) ZA200509515B (enExample)

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US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
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WO2006066133A2 (en) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
MX2007011148A (es) * 2005-03-11 2008-02-22 Univ Colorado Inhibidores de histona desacetilasa que sensibilizan celulas cancerosas respecto a los inhibidores de factor de crecimiento.
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JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
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US8383855B2 (en) 2006-02-14 2013-02-26 President And Fellows Of Harvard College Histone deacetylase inhibitors
JP5441416B2 (ja) 2006-02-14 2014-03-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二官能性ヒストンデアセチラーゼインヒビター
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US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
WO2009079375A1 (en) * 2007-12-14 2009-06-25 Georgetown University Histone deacetylase inhibitors
KR101708946B1 (ko) 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. 탈아세틸화제 억제제 및 그것의 용도
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BRPI0918580B8 (pt) * 2008-08-29 2021-05-25 Bayer Ip Gmbh polimorfo cristalino b da n-(2-aminofenil)-4-[n-(piridina3-il)metóxi-carbonilaminometil]-benzamida, composição e combinação contendo o mesmo, uso e seu processo de produção
EP2376485B1 (en) 2008-12-19 2017-12-06 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
WO2010093561A1 (en) * 2009-02-11 2010-08-19 Liangping Yu Particulate composition and the method of making the same
CN102573826A (zh) * 2009-05-01 2012-07-11 奥克兹美制药公司 用于治疗癌症的喷他脒组合
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KR20120053052A (ko) * 2009-08-25 2012-05-24 아브락시스 바이오사이언스, 엘엘씨 헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법
KR20130066633A (ko) 2010-05-12 2013-06-20 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 억제제로서 유용한 화합물
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BR112014007690B1 (pt) * 2011-09-30 2022-10-04 Vertex Pharmaceuticals Incorporated Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas
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US8999632B2 (en) 2012-10-04 2015-04-07 Vertex Pharmaceuticals Incorporated Method for measuring ATR inhibition mediated increases in DNA damage
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Publication number Priority date Publication date Assignee Title
WO2025041160A1 (en) * 2023-08-19 2025-02-27 Birla Institute Of Technology And Science (Bits), Pilani Bifunctional conjugate molecules for cancer treatment and process of making the same

Also Published As

Publication number Publication date
MEP32308A (en) 2010-10-10
KR100938712B1 (ko) 2010-01-25
EP1626719A1 (en) 2006-02-22
ECSP056253A (es) 2006-10-25
AU2004241873B8 (en) 2008-05-29
RU2005140570A (ru) 2006-06-10
CN1794991A (zh) 2006-06-28
IL171941A0 (en) 2006-04-10
NO20055417L (no) 2005-12-19
ZA200509515B (en) 2006-07-26
JP2006526031A (ja) 2006-11-16
US20070098816A1 (en) 2007-05-03
AU2004241873C1 (en) 2009-01-22
CL2004001278A1 (es) 2005-05-06
UA81499C2 (en) 2008-01-10
RS20050884A (sr) 2008-04-04
AU2004241873B2 (en) 2008-05-08
NZ543591A (en) 2009-09-25
MXPA05012345A (es) 2006-02-08
BRPI0410959A (pt) 2006-07-04
CA2634765A1 (en) 2004-12-02
CU23490B7 (es) 2010-02-23
PE20050206A1 (es) 2005-03-26
AU2004241873A1 (en) 2004-12-02
CA2634709A1 (en) 2004-12-02
UY28330A1 (es) 2004-12-31
TW200505424A (en) 2005-02-16
NO20055417D0 (no) 2005-11-16
KR20060009371A (ko) 2006-01-31
CO5660262A2 (es) 2006-07-31
CN101322707A (zh) 2008-12-17
WO2004103369A1 (en) 2004-12-02
CA2527191A1 (en) 2004-12-02
CA2634766A1 (en) 2004-12-02
AR045318A1 (es) 2005-10-26
CR8163A (es) 2006-07-14

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