RU2315768C2 - ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ αLβ2-ИНТЕГРИНАМИ - Google Patents

ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ αLβ2-ИНТЕГРИНАМИ Download PDF

Info

Publication number
RU2315768C2
RU2315768C2 RU2004123219/04A RU2004123219A RU2315768C2 RU 2315768 C2 RU2315768 C2 RU 2315768C2 RU 2004123219/04 A RU2004123219/04 A RU 2004123219/04A RU 2004123219 A RU2004123219 A RU 2004123219A RU 2315768 C2 RU2315768 C2 RU 2315768C2
Authority
RU
Russia
Prior art keywords
compound
salt
formula
compounds
pharmaceutically acceptable
Prior art date
Application number
RU2004123219/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2004123219A (ru
Inventor
Ила СИРКАР
Маршалл МОРНИНГСТАР
Масатоши КАКУШИМА
Хидефуми КАДЗИ
Такаюки КАВАГУТИ
Тошиюки КУМЕ
Original Assignee
Танабе Сейяку Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Танабе Сейяку Ко., Лтд. filed Critical Танабе Сейяку Ко., Лтд.
Publication of RU2004123219A publication Critical patent/RU2004123219A/ru
Application granted granted Critical
Publication of RU2315768C2 publication Critical patent/RU2315768C2/ru

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
RU2004123219/04A 2002-02-07 2003-02-06 ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ αLβ2-ИНТЕГРИНАМИ RU2315768C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35430902P 2002-02-07 2002-02-07
US60/354,309 2002-02-07

Publications (2)

Publication Number Publication Date
RU2004123219A RU2004123219A (ru) 2006-02-10
RU2315768C2 true RU2315768C2 (ru) 2008-01-27

Family

ID=27734354

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004123219/04A RU2315768C2 (ru) 2002-02-07 2003-02-06 ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ αLβ2-ИНТЕГРИНАМИ

Country Status (23)

Country Link
US (1) US7375128B2 (enExample)
EP (1) EP1472257B1 (enExample)
JP (1) JP2005517016A (enExample)
KR (1) KR100625379B1 (enExample)
CN (1) CN1301255C (enExample)
AR (1) AR040068A1 (enExample)
AT (1) ATE411995T1 (enExample)
AU (1) AU2003210862B2 (enExample)
BR (1) BR0307521A (enExample)
CA (1) CA2474748A1 (enExample)
CO (1) CO5601028A2 (enExample)
DE (1) DE60324250D1 (enExample)
EC (1) ECSP045222A (enExample)
MX (1) MXPA04007643A (enExample)
MY (1) MY137878A (enExample)
NO (1) NO20043563L (enExample)
NZ (1) NZ534208A (enExample)
PE (1) PE20030899A1 (enExample)
PL (1) PL372328A1 (enExample)
RU (1) RU2315768C2 (enExample)
TW (1) TW200303200A (enExample)
WO (1) WO2003066636A1 (enExample)
ZA (1) ZA200405647B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7632858B2 (en) 2002-11-15 2009-12-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
JP2009510150A (ja) * 2005-10-06 2009-03-12 ノバルティス アクチエンゲゼルシャフト Lfa−1メディエーターとしてのテトラヒドロ−ピロリジノン化合物
CN101638429B (zh) * 2009-08-28 2012-01-25 南方医科大学 一种特异性识别细胞表面整合素α3β1的小分子肽
US8497288B2 (en) * 2011-05-09 2013-07-30 Hoffmann-La Roche Inc. Hexahydropyrroloimidazolone compounds
EP3969066B1 (en) * 2019-05-16 2025-08-20 Dispensing Dynamics International, Inc. Fragrance dispenser

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214834B1 (en) * 1997-03-28 2001-04-10 Dupont Pharmaceuticals Company Integrin inhibitor prodrugs
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION
RU2174119C2 (ru) * 1996-06-05 2001-09-27 Хехст Акциенгезельшафт Соли этилового эфира 3-(2-(4-(4-(аминоиминометил)фенил)-4-метил-2,5-диоксоимидазолидин-1-ил)ацетиламино)-3-фенилпропионовой кислоты, способ их получения и фармацевтическая композиция на их основе
WO2001089552A1 (en) * 2000-05-23 2001-11-29 Histatek, Llc Modulaton of alpha-6 integrin-mediated responses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643748A1 (de) 1986-12-20 1988-06-30 Hoechst Ag Bicylische imide, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
DK0966447T3 (da) 1997-03-03 2003-06-23 Boehringer Ingelheim Pharma Anvendelige små molekyler til behandling af betændelsessygdomme
DE69837264T2 (de) 1997-06-25 2008-01-31 Pfizer Inc. Dipeptidverbindungen, die Wachstumshormon-Sekretagoga sind

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174119C2 (ru) * 1996-06-05 2001-09-27 Хехст Акциенгезельшафт Соли этилового эфира 3-(2-(4-(4-(аминоиминометил)фенил)-4-метил-2,5-диоксоимидазолидин-1-ил)ацетиламино)-3-фенилпропионовой кислоты, способ их получения и фармацевтическая композиция на их основе
US6214834B1 (en) * 1997-03-28 2001-04-10 Dupont Pharmaceuticals Company Integrin inhibitor prodrugs
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION
WO2001089552A1 (en) * 2000-05-23 2001-11-29 Histatek, Llc Modulaton of alpha-6 integrin-mediated responses

Also Published As

Publication number Publication date
NZ534208A (en) 2005-12-23
MY137878A (en) 2009-03-31
EP1472257A1 (en) 2004-11-03
TW200303200A (en) 2003-09-01
AU2003210862B2 (en) 2006-10-26
ECSP045222A (es) 2006-04-19
DE60324250D1 (de) 2008-12-04
US7375128B2 (en) 2008-05-20
AU2003210862A1 (en) 2003-09-02
BR0307521A (pt) 2004-12-28
JP2005517016A (ja) 2005-06-09
CN1628116A (zh) 2005-06-15
ATE411995T1 (de) 2008-11-15
EP1472257B1 (en) 2008-10-22
ZA200405647B (en) 2005-07-15
AR040068A1 (es) 2005-03-16
CN1301255C (zh) 2007-02-21
NO20043563L (no) 2004-11-01
KR20040091625A (ko) 2004-10-28
CO5601028A2 (es) 2006-01-31
WO2003066636A1 (en) 2003-08-14
PL372328A1 (en) 2005-07-11
RU2004123219A (ru) 2006-02-10
MXPA04007643A (es) 2005-06-08
KR100625379B1 (ko) 2006-09-20
CA2474748A1 (en) 2003-08-14
PE20030899A1 (es) 2003-10-25
US20050171174A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
KR102398941B1 (ko) Pad4의 공유결합성 억제제
JP2010521513A (ja) アザ−ピリドピリミジノン誘導体
RU2315768C2 (ru) ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ αLβ2-ИНТЕГРИНАМИ
AU2001253538B2 (en) Inhibitors of alpha l beta 2 mediated cell adhesion
EP2284172A1 (en) Immunomodulating heterocyclic compounds
US8481750B2 (en) Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides
CA2365419A1 (en) Novel thiazolobenzoimidazole derivatives
CA2380852C (en) Tricyclic compounds having spiro union
EP2917204B1 (fr) Derives de 1h-indole-3-carboxamide et leurs utilisation comme antagonistes du p2y12
JP2023521200A (ja) 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体
EP4452985A1 (en) Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists
JP2005068145A (ja) 医薬組成物
AU2004220310B2 (en) Immunomodulating heterocyclic compounds
JPH07173161A (ja) ピリドピリミジン誘導体、その製造方法および用途
HK1090921B (en) Immunomodulating heterocyclic compounds

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20090207