PE20030899A1 - INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2 - Google Patents

INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2

Info

Publication number
PE20030899A1
PE20030899A1 PE2003000137A PE2003000137A PE20030899A1 PE 20030899 A1 PE20030899 A1 PE 20030899A1 PE 2003000137 A PE2003000137 A PE 2003000137A PE 2003000137 A PE2003000137 A PE 2003000137A PE 20030899 A1 PE20030899 A1 PE 20030899A1
Authority
PE
Peru
Prior art keywords
octane
integrin
diona
cyanobenzyl
dichlorophenyl
Prior art date
Application number
PE2003000137A
Other languages
English (en)
Inventor
Hidefumi Kaji
Masatoshi Kakushima
Toshiyuki Kume
Ila Sircar
Marshall Morningstar
Takayuki Kawaguchi
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of PE20030899A1 publication Critical patent/PE20030899A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)

Abstract

SE REFIERE A COMPUESTO AZABICICLO OCTANOS DE FORMULA I DONDE R ES H, HIDROXILO, CARBAMOILO; n ES 1-2. SON COMPUESTOS PREFERIDOS (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-ACETILAMINO-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA; (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-[(2-HIDROXI-ACETIL)AMINO]-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA; (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-[(3-CARMAMOIL-PROPIONIL)AMINO]-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES POTENTES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA OLß2 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDAD AUTOINMUNE, ALERGICA COMO ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, CONDICIONES ALERGICAS, PSORIASIS, ESCLEROSIS MULTIPLE, RECHAZO DESPUES DEL TRASPLANTE DE ORGANOS
PE2003000137A 2002-02-07 2003-02-06 INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2 PE20030899A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35430902P 2002-02-07 2002-02-07

Publications (1)

Publication Number Publication Date
PE20030899A1 true PE20030899A1 (es) 2003-10-25

Family

ID=27734354

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000137A PE20030899A1 (es) 2002-02-07 2003-02-06 INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2

Country Status (23)

Country Link
US (1) US7375128B2 (es)
EP (1) EP1472257B1 (es)
JP (1) JP2005517016A (es)
KR (1) KR100625379B1 (es)
CN (1) CN1301255C (es)
AR (1) AR040068A1 (es)
AT (1) ATE411995T1 (es)
AU (1) AU2003210862B2 (es)
BR (1) BR0307521A (es)
CA (1) CA2474748A1 (es)
CO (1) CO5601028A2 (es)
DE (1) DE60324250D1 (es)
EC (1) ECSP045222A (es)
MX (1) MXPA04007643A (es)
MY (1) MY137878A (es)
NO (1) NO20043563L (es)
NZ (1) NZ534208A (es)
PE (1) PE20030899A1 (es)
PL (1) PL372328A1 (es)
RU (1) RU2315768C2 (es)
TW (1) TW200303200A (es)
WO (1) WO2003066636A1 (es)
ZA (1) ZA200405647B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
KR20080050605A (ko) * 2005-10-06 2008-06-09 노파르티스 아게 Ｌｆａ-ｉ 조정 인자로서의 테트라히드로-피롤리지논화합물
CN101638429B (zh) * 2009-08-28 2012-01-25 南方医科大学 一种特异性识别细胞表面整合素α3β1的小分子肽
US8497288B2 (en) * 2011-05-09 2013-07-30 Hoffmann-La Roche Inc. Hexahydropyrroloimidazolone compounds
EP3969066A4 (en) * 2019-05-16 2023-10-04 Dispensing Dynamics International, Inc. PERFUME DISPENSERS AND METHODS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643748A1 (de) 1986-12-20 1988-06-30 Hoechst Ag Bicylische imide, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
CN1249748A (zh) 1997-03-03 2000-04-05 贝林格尔·英格海姆药物公司 用于治疗炎症疾病的小分子
AU7445498A (en) 1997-06-25 1999-01-04 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
PT1307455E (pt) * 1999-10-20 2005-06-30 Tanabe Seiyaku Co Inibidores de adesao celular mediada por (alfa)l (beta)2

Also Published As

Publication number Publication date
KR20040091625A (ko) 2004-10-28
ZA200405647B (en) 2005-07-15
DE60324250D1 (de) 2008-12-04
RU2004123219A (ru) 2006-02-10
AU2003210862A1 (en) 2003-09-02
KR100625379B1 (ko) 2006-09-20
ECSP045222A (es) 2006-04-19
MY137878A (en) 2009-03-31
PL372328A1 (en) 2005-07-11
RU2315768C2 (ru) 2008-01-27
EP1472257B1 (en) 2008-10-22
TW200303200A (en) 2003-09-01
US20050171174A1 (en) 2005-08-04
CN1301255C (zh) 2007-02-21
AR040068A1 (es) 2005-03-16
EP1472257A1 (en) 2004-11-03
NZ534208A (en) 2005-12-23
MXPA04007643A (es) 2005-06-08
AU2003210862B2 (en) 2006-10-26
NO20043563L (no) 2004-11-01
JP2005517016A (ja) 2005-06-09
ATE411995T1 (de) 2008-11-15
CO5601028A2 (es) 2006-01-31
CA2474748A1 (en) 2003-08-14
WO2003066636A1 (en) 2003-08-14
US7375128B2 (en) 2008-05-20
CN1628116A (zh) 2005-06-15
BR0307521A (pt) 2004-12-28

Similar Documents

Publication Publication Date Title
CA2520898C (en) Non-cross-linking pyrrolo(2,1-c)(1,4)benzodiazepines as potential antitumour agents and process thereof
PE20030899A1 (es) INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2
JP3593035B2 (ja) 二環式窒素複素環化合物
CA2227991C (en) 1,2,4-triazolo[1,5-c]pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2a receptor
JP2002501922A (ja) アゾロトリアジン類およびアゾロピリミジン類
MA29437B1 (fr) Compose d'imidazopyridazine
WO2005058901A8 (de) Neue 2-(piperazin-1-yl)- und 2-([1,4]diazepan-1-yl)- imidazo[4,5-d]pyridazin-4-one, deren herstellung und deren verwendung als arzneimittel zur bekämpfung von diabetes mellitus
DE502005006204D1 (de) 8- ä3-amino-piperidin-1-ylü-xanthine, deren herstellung und deren verwendung als arzneimittel
EA200100922A1 (ru) Бициклические гетероциклы, фармацевтические композиции, содержащие эти соединения, и способы их получения
NO310359B1 (no) Pyrrolopyrimidiner og fremgangsmåter for fremstilling av samme, farmasöytisk sammensetning omfattende samme, samtanvendelse av samme for fremstilling av legemiddel
ATE384050T1 (de) Benzazepinderivate als histamin-h3-antagonisten
WO2006052962A3 (en) Bicyclic triazole a4 integrin inhibitors
PE20151249A1 (es) Derivados de pirazolopirimidina como inhibidores de jak quinasas
AU2004272437A1 (en) CRF antagonists and heterobicyclic compounds
RO121272B1 (ro) Azolotriazine şi pirimidine
MX9405132A (es) Tetrahidro pirazolopiridinas biciclicas.
RU2008129620A (ru) Пиразиноилгуанидиновые соединения, применяемые в лечении воспалительных или аллергических заболеваний
NZ554082A (en) Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists
EP2010185A1 (de) Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
BRPI0517412A (pt) derivados de benzodiazepina substituìdos
MA29623B1 (fr) Derives de pyrazolo [3, 4-d] azepine comme antagonistes d'histamine h3
UY29451A1 (es) Derivados novedosos de (1,3)tiazolo(4,5-d)pirimidin-2-(3h)-ona 5,7-disustituida
YU30902A (sh) Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju
AR032986A1 (es) 4-( 2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3il)pirazol- (1,5-a)-1,3,5-triazina, sus enantiomeros y sales aceptables para uso farmaceutico como ligandos del receptor del factor liberador de corticotropina
US20040176376A1 (en) Pyrazolotriazines as CRF antagonists

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed