PE20030899A1 - INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2 - Google Patents
INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2Info
- Publication number
- PE20030899A1 PE20030899A1 PE2003000137A PE2003000137A PE20030899A1 PE 20030899 A1 PE20030899 A1 PE 20030899A1 PE 2003000137 A PE2003000137 A PE 2003000137A PE 2003000137 A PE2003000137 A PE 2003000137A PE 20030899 A1 PE20030899 A1 PE 20030899A1
- Authority
- PE
- Peru
- Prior art keywords
- octane
- integrin
- diona
- cyanobenzyl
- dichlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
Abstract
SE REFIERE A COMPUESTO AZABICICLO OCTANOS DE FORMULA I DONDE R ES H, HIDROXILO, CARBAMOILO; n ES 1-2. SON COMPUESTOS PREFERIDOS (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-ACETILAMINO-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA; (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-[(2-HIDROXI-ACETIL)AMINO]-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA; (5S,7S)-5-(4-CIANOBENCIL)-3-(3,5-DICLOROFENIL)-7-[(3-CARMAMOIL-PROPIONIL)AMINO]-1,3-DIAZABICICLO[3.3.0]OCTANO-2,4-DIONA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES POTENTES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA OLß2 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDAD AUTOINMUNE, ALERGICA COMO ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, CONDICIONES ALERGICAS, PSORIASIS, ESCLEROSIS MULTIPLE, RECHAZO DESPUES DEL TRASPLANTE DE ORGANOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35430902P | 2002-02-07 | 2002-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030899A1 true PE20030899A1 (es) | 2003-10-25 |
Family
ID=27734354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000137A PE20030899A1 (es) | 2002-02-07 | 2003-02-06 | INHIBIDORES DE LA ADHESION CELULAR MEDIADA POR INTEGRINA aLß2 |
Country Status (23)
Country | Link |
---|---|
US (1) | US7375128B2 (es) |
EP (1) | EP1472257B1 (es) |
JP (1) | JP2005517016A (es) |
KR (1) | KR100625379B1 (es) |
CN (1) | CN1301255C (es) |
AR (1) | AR040068A1 (es) |
AT (1) | ATE411995T1 (es) |
AU (1) | AU2003210862B2 (es) |
BR (1) | BR0307521A (es) |
CA (1) | CA2474748A1 (es) |
CO (1) | CO5601028A2 (es) |
DE (1) | DE60324250D1 (es) |
EC (1) | ECSP045222A (es) |
MX (1) | MXPA04007643A (es) |
MY (1) | MY137878A (es) |
NO (1) | NO20043563L (es) |
NZ (1) | NZ534208A (es) |
PE (1) | PE20030899A1 (es) |
PL (1) | PL372328A1 (es) |
RU (1) | RU2315768C2 (es) |
TW (1) | TW200303200A (es) |
WO (1) | WO2003066636A1 (es) |
ZA (1) | ZA200405647B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
TW200407324A (en) * | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
US7199125B2 (en) | 2003-10-02 | 2007-04-03 | Bristol-Myers Squibb Company | Spiro-cyclic compounds useful as anti-inflammatory agents |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
KR20080050605A (ko) * | 2005-10-06 | 2008-06-09 | 노파르티스 아게 | Lfa-i 조정 인자로서의 테트라히드로-피롤리지논화합물 |
CN101638429B (zh) * | 2009-08-28 | 2012-01-25 | 南方医科大学 | 一种特异性识别细胞表面整合素α3β1的小分子肽 |
US8497288B2 (en) * | 2011-05-09 | 2013-07-30 | Hoffmann-La Roche Inc. | Hexahydropyrroloimidazolone compounds |
EP3969066A4 (en) * | 2019-05-16 | 2023-10-04 | Dispensing Dynamics International, Inc. | PERFUME DISPENSERS AND METHODS |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3643748A1 (de) | 1986-12-20 | 1988-06-30 | Hoechst Ag | Bicylische imide, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz |
CN1249748A (zh) | 1997-03-03 | 2000-04-05 | 贝林格尔·英格海姆药物公司 | 用于治疗炎症疾病的小分子 |
AU7445498A (en) | 1997-06-25 | 1999-01-04 | Pfizer Inc. | Dipeptide derivatives as growth hormone secretagogues |
PT1307455E (pt) * | 1999-10-20 | 2005-06-30 | Tanabe Seiyaku Co | Inibidores de adesao celular mediada por (alfa)l (beta)2 |
-
2003
- 2003-01-21 TW TW092101214A patent/TW200303200A/zh unknown
- 2003-01-27 MY MYPI20030269A patent/MY137878A/en unknown
- 2003-02-06 EP EP03737649A patent/EP1472257B1/en not_active Expired - Lifetime
- 2003-02-06 AT AT03737649T patent/ATE411995T1/de not_active IP Right Cessation
- 2003-02-06 JP JP2003566009A patent/JP2005517016A/ja not_active Ceased
- 2003-02-06 BR BR0307521-4A patent/BR0307521A/pt not_active IP Right Cessation
- 2003-02-06 CN CNB038034727A patent/CN1301255C/zh not_active Expired - Fee Related
- 2003-02-06 CA CA002474748A patent/CA2474748A1/en not_active Abandoned
- 2003-02-06 AU AU2003210862A patent/AU2003210862B2/en not_active Ceased
- 2003-02-06 MX MXPA04007643A patent/MXPA04007643A/es active IP Right Grant
- 2003-02-06 AR ARP030100379A patent/AR040068A1/es unknown
- 2003-02-06 PE PE2003000137A patent/PE20030899A1/es not_active Application Discontinuation
- 2003-02-06 PL PL03372328A patent/PL372328A1/xx not_active Application Discontinuation
- 2003-02-06 NZ NZ534208A patent/NZ534208A/en unknown
- 2003-02-06 US US10/503,602 patent/US7375128B2/en not_active Expired - Fee Related
- 2003-02-06 DE DE60324250T patent/DE60324250D1/de not_active Expired - Fee Related
- 2003-02-06 RU RU2004123219/04A patent/RU2315768C2/ru not_active IP Right Cessation
- 2003-02-06 KR KR1020047010969A patent/KR100625379B1/ko not_active IP Right Cessation
- 2003-02-06 WO PCT/US2003/003449 patent/WO2003066636A1/en active IP Right Grant
-
2004
- 2004-07-15 ZA ZA200405647A patent/ZA200405647B/en unknown
- 2004-08-05 CO CO04076121A patent/CO5601028A2/es unknown
- 2004-08-06 EC EC2004005222A patent/ECSP045222A/es unknown
- 2004-08-26 NO NO20043563A patent/NO20043563L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20040091625A (ko) | 2004-10-28 |
ZA200405647B (en) | 2005-07-15 |
DE60324250D1 (de) | 2008-12-04 |
RU2004123219A (ru) | 2006-02-10 |
AU2003210862A1 (en) | 2003-09-02 |
KR100625379B1 (ko) | 2006-09-20 |
ECSP045222A (es) | 2006-04-19 |
MY137878A (en) | 2009-03-31 |
PL372328A1 (en) | 2005-07-11 |
RU2315768C2 (ru) | 2008-01-27 |
EP1472257B1 (en) | 2008-10-22 |
TW200303200A (en) | 2003-09-01 |
US20050171174A1 (en) | 2005-08-04 |
CN1301255C (zh) | 2007-02-21 |
AR040068A1 (es) | 2005-03-16 |
EP1472257A1 (en) | 2004-11-03 |
NZ534208A (en) | 2005-12-23 |
MXPA04007643A (es) | 2005-06-08 |
AU2003210862B2 (en) | 2006-10-26 |
NO20043563L (no) | 2004-11-01 |
JP2005517016A (ja) | 2005-06-09 |
ATE411995T1 (de) | 2008-11-15 |
CO5601028A2 (es) | 2006-01-31 |
CA2474748A1 (en) | 2003-08-14 |
WO2003066636A1 (en) | 2003-08-14 |
US7375128B2 (en) | 2008-05-20 |
CN1628116A (zh) | 2005-06-15 |
BR0307521A (pt) | 2004-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |