RU2303259C2 - Терапевтическое применение селективных ингибиторов pde10 - Google Patents

Терапевтическое применение селективных ингибиторов pde10 Download PDF

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RU2303259C2
RU2303259C2 RU2004132198/15A RU2004132198A RU2303259C2 RU 2303259 C2 RU2303259 C2 RU 2303259C2 RU 2004132198/15 A RU2004132198/15 A RU 2004132198/15A RU 2004132198 A RU2004132198 A RU 2004132198A RU 2303259 C2 RU2303259 C2 RU 2303259C2
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pde10
neurons
selective
inhibitor
pde
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RU2004132198/15A
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Russian (ru)
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RU2004132198A (ru
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Лоррейн Энн ЛЕБЕЛ (US)
Лоррейн Энн ЛЕБЕЛ
Франк Сэмьюэль МЕННИТИ (US)
Франк Сэмьюэль МЕННИТИ
Кристофер Джозеф ШМИДТ (US)
Кристофер Джозеф ШМИДТ
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Пфайзер Продактс Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/301—Anxiety or phobic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

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  • General Engineering & Computer Science (AREA)
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RU2004132198/15A 2002-05-03 2003-04-22 Терапевтическое применение селективных ингибиторов pde10 RU2303259C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/139,183 US20030018047A1 (en) 2001-04-20 2002-05-03 Therapeutic use of selective PDE10 inhibitors
US10/139,183 2002-05-03
US10/177,018 2002-06-20
US10/177,018 US20030032579A1 (en) 2001-04-20 2002-06-20 Therapeutic use of selective PDE10 inhibitors

Publications (2)

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RU2004132198A RU2004132198A (ru) 2005-04-20
RU2303259C2 true RU2303259C2 (ru) 2007-07-20

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US (2) US20030032579A1 (OSRAM)
EP (1) EP1504118A2 (OSRAM)
JP (1) JP2005524402A (OSRAM)
KR (1) KR20040106455A (OSRAM)
CN (1) CN1668761A (OSRAM)
AU (1) AU2003222395A1 (OSRAM)
BR (1) BR0309746A (OSRAM)
CA (1) CA2484600A1 (OSRAM)
HR (1) HRP20041029A2 (OSRAM)
IL (1) IL164778A0 (OSRAM)
MX (1) MXPA04010777A (OSRAM)
NO (1) NO20044470L (OSRAM)
PL (1) PL373943A1 (OSRAM)
RU (1) RU2303259C2 (OSRAM)
TW (1) TWI269812B (OSRAM)
WO (1) WO2003093499A2 (OSRAM)

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KR20060030483A (ko) * 2003-06-30 2006-04-10 알타나 파마 아게 Ｐｄｅ10 억제제로서 피롤로디히드로이소퀴놀린
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US7576080B2 (en) * 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
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CN110346004B (zh) * 2019-08-16 2020-08-21 杭州山科智能科技股份有限公司 一种双声道超声时差法的流量测量数据融合方法
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Soderling S.H. et al. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A, Proc Natl Acad Sci USA. 08.06.1999, Vol.96, №12, p.7071-7076, abstract. Loughney К. et al. Isolation and characterization of PDE10A, a novel human 3′,5′-cyclic nucleotide phosphodiesterase, Gene. 24.06.1999, 234(1), p.109-117, abstract. *

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WO2003093499A2 (en) 2003-11-13
KR20040106455A (ko) 2004-12-17
IL164778A0 (en) 2005-12-18
CN1668761A (zh) 2005-09-14
US20040162294A1 (en) 2004-08-19
HRP20041029A2 (en) 2004-12-31
WO2003093499A3 (en) 2004-04-22
BR0309746A (pt) 2007-03-27
EP1504118A2 (en) 2005-02-09
PL373943A1 (en) 2005-09-19
MXPA04010777A (es) 2005-03-07
NO20044470L (no) 2004-11-04
AU2003222395A1 (en) 2003-11-17
CA2484600A1 (en) 2003-11-13
TW200307751A (en) 2003-12-16
US20030032579A1 (en) 2003-02-13
TWI269812B (en) 2007-01-01
JP2005524402A (ja) 2005-08-18
RU2004132198A (ru) 2005-04-20

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