BR0309746A - uso terapêutico de inibidores seletivos de pde10 - Google Patents

uso terapêutico de inibidores seletivos de pde10

Info

Publication number
BR0309746A
BR0309746A BRPI0309746-3A BR0309746A BR0309746A BR 0309746 A BR0309746 A BR 0309746A BR 0309746 A BR0309746 A BR 0309746A BR 0309746 A BR0309746 A BR 0309746A
Authority
BR
Brazil
Prior art keywords
present
selective
relates
disorders
selective pde10
Prior art date
Application number
BRPI0309746-3A
Other languages
English (en)
Inventor
Lorraine Ann Lebel
Frank Samuel Menniti
Christopher Joseph Schmidt
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/139,183 external-priority patent/US20030018047A1/en
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0309746A publication Critical patent/BR0309746A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/301—Anxiety or phobic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

"USO TERAPêUTICO DE INIBIDORES SELETIVOS DE PDE10". A presente invenção refere-se a um método para tratamento de certos distúrbios neurológicos e psiquiátricos em mamíferos, incluindo seres humanos, compreendendo a administração de um inibidor seletivo de PDE10. Em particular, a presente invenção refere-se ao tratamento de distúrbios de humor, movimento e ansiedade; psicose; dependência de drogas, por exemplo álcool; distúrbios que têm como sintoma deficiente cognição; e distúrbios e condições neurodegenerativos. A presente invenção refere-se além disso ã utilização de papaverina como inibidor seletivo de PDE10. A presente invenção refere-se também a ensaios para identificação de compostos químicos que têm atividade como inibidores seletivos de PDE10.
BRPI0309746-3A 2002-05-03 2003-04-22 uso terapêutico de inibidores seletivos de pde10 BR0309746A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/139,183 US20030018047A1 (en) 2001-04-20 2002-05-03 Therapeutic use of selective PDE10 inhibitors
US10/177,018 US20030032579A1 (en) 2001-04-20 2002-06-20 Therapeutic use of selective PDE10 inhibitors
PCT/IB2003/001684 WO2003093499A2 (en) 2002-05-03 2003-04-22 Therapeutic use of selective pde10 inhibitors

Publications (1)

Publication Number Publication Date
BR0309746A true BR0309746A (pt) 2007-03-27

Family

ID=29406263

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0309746-3A BR0309746A (pt) 2002-05-03 2003-04-22 uso terapêutico de inibidores seletivos de pde10

Country Status (16)

Country Link
US (2) US20030032579A1 (pt)
EP (1) EP1504118A2 (pt)
JP (1) JP2005524402A (pt)
KR (1) KR20040106455A (pt)
CN (1) CN1668761A (pt)
AU (1) AU2003222395A1 (pt)
BR (1) BR0309746A (pt)
CA (1) CA2484600A1 (pt)
HR (1) HRP20041029A2 (pt)
IL (1) IL164778A0 (pt)
MX (1) MXPA04010777A (pt)
NO (1) NO20044470L (pt)
PL (1) PL373943A1 (pt)
RU (1) RU2303259C2 (pt)
TW (1) TWI269812B (pt)
WO (1) WO2003093499A2 (pt)

Families Citing this family (68)

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JP2008501776A (ja) * 2004-06-07 2008-01-24 ファイザー・プロダクツ・インク 肥満に関連し、かつメタボリックシンドロームに関連する状態の治療としてのホスホジエステラーゼ１０の阻害
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Also Published As

Publication number Publication date
TW200307751A (en) 2003-12-16
NO20044470L (no) 2004-11-04
JP2005524402A (ja) 2005-08-18
RU2004132198A (ru) 2005-04-20
IL164778A0 (en) 2005-12-18
KR20040106455A (ko) 2004-12-17
AU2003222395A1 (en) 2003-11-17
TWI269812B (en) 2007-01-01
CA2484600A1 (en) 2003-11-13
WO2003093499A2 (en) 2003-11-13
HRP20041029A2 (en) 2004-12-31
RU2303259C2 (ru) 2007-07-20
US20040162294A1 (en) 2004-08-19
US20030032579A1 (en) 2003-02-13
EP1504118A2 (en) 2005-02-09
PL373943A1 (en) 2005-09-19
MXPA04010777A (es) 2005-03-07
WO2003093499A3 (en) 2004-04-22
CN1668761A (zh) 2005-09-14

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