RU2227916C2 - Количественный анализ для выявления присутствия неоплодотворяемых яйцеклеток - Google Patents
Количественный анализ для выявления присутствия неоплодотворяемых яйцеклеток Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract 13
- 238000004445 quantitative analysis Methods 0.000 title claims 2
- 210000000287 oocyte Anatomy 0.000 title abstract 2
- 230000027758 ovulation cycle Effects 0.000 claims abstract 5
- 239000005556 hormone Substances 0.000 claims abstract 4
- 229940088597 hormone Drugs 0.000 claims abstract 4
- 239000000813 peptide hormone Substances 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 4
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract 3
- 229960005309 estradiol Drugs 0.000 claims abstract 3
- 229930182833 estradiol Natural products 0.000 claims abstract 3
- 238000000338 in vitro Methods 0.000 claims abstract 3
- 102000004190 Enzymes Human genes 0.000 claims abstract 2
- 108090000790 Enzymes Proteins 0.000 claims abstract 2
- 230000003834 intracellular effect Effects 0.000 claims abstract 2
- 150000002632 lipids Chemical class 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 102000039446 nucleic acids Human genes 0.000 claims abstract 2
- 230000031877 prophase Effects 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 235000013601 eggs Nutrition 0.000 claims 3
- 108010067471 inhibin A Proteins 0.000 claims 3
- 230000004720 fertilization Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 1
- 108010038988 Peptide Hormones Proteins 0.000 abstract 1
- 102000015731 Peptide Hormones Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000005470 impregnation Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0609—Oocytes, oogonia
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- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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Abstract
Изобретение относится к медицине, а именно к определению времени аспирации, когда у млекопитающего имеются неоплодотворяемые яйцеклетки, способные к созреванию in vitro и последующему оплодотворению. Сущность способа: в образце секрета организма, полученного у самки млекопитающего в различное время в течение менструального цикла, определяют присутствие или количество по меньшей мере одного вещества - прогностического маркера, которое характеризует, когда у млекопитающего присутствуют неоплодотворяемые яйцеклетки, находящиеся в профазе, способные к созреванию in vitro и последующему оплодотворению. В качестве таких маркеров могут быть использованы гормоны, мелкие пептидные гормоны, пептидные гормоны, липиды, нуклеиновая кислота, внутри- или межклеточный посредник или фермент. Прогностическими маркерами являются такие гормоны, как эстрадиол и ингибин А. Способ позволяет повысить эффективность экстракорпорального оплодотворения. 10 з.п.ф-лы, 20 табл.
Description
Текст описания в факсимильном виде (см. графическую часть).
Claims (11)
1. Способ определения времени аспирации, когда у млекопитающего имеются неоплодотворяемые яйцеклетки, способные к созреванию in vitro и последующему оплодотворению, содержащий а) получение образца у самки млекопитающего в различное время в течение менструального цикла, в) количественный анализ на присутствие или количество по меньшей мере одного вещества, выбранного из группы, состоящей из гормона, мелкого пептидного гормона, пептидного гормона, липида, нуклеиновой кислоты, внутри- или межклеточного посредника или фермента, c) корреляцию присутствия или количества указанного по меньшей мере одного вещества с соответствующей величиной для определения, присутствуют ли неоплодотворяемые яйцеклетки, находящиеся в профазе, способные к созреванию in vitro и последующему оплодотворению, и d) последующее извлечение яйцеклеток у указанного млекопитающего.
2. Способ по п.1, в котором образец выбирают из группы, состоящей из секрета организма, мокроты, крови, мочи или маточного секрета у млекопитающего.
3. Способ по п.1 или 2, в котором образец является образцом крови.
4. Способ по любому из предшествующих пунктов, в котором млекопитающее является приматом.
5. Способ по любому из предшествующих пунктов, в котором млекопитающее является человеком.
6. Способ по любому из предшествующих пунктов, в котором присутствие или количество определяют с помощью иммуноанализа и/или полимеразной цепной реакции.
7. Способ по любому из предшествующих пунктов, в котором определяют присутствие или количество ингибина А.
8. Способ по любому из предшествующих пунктов, в котором время определяют на 3-й день менструального цикла по количеству ингибина А в образце крови, которое составляет менее 10 пкг/мл.
9. Способ по любому из предшествующих пунктов, в котором время определяют по увеличению количества ингибина А в образце крови более чем на 80% с 3-го дня менструального цикла до дня аспирации.
10. Способ по любому из предшествующих пунктов, в котором определяют присутствие или количество эстрадиола.
11. Способ по любому из предшествующих пунктов, в котором время определяют по увеличению количества эстрадиола в образце крови более, чем на 87% с 3-го дня менструального цикла до дня аспирации.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9011598P | 1998-06-22 | 1998-06-22 | |
| DK199900885A DK199900885A (da) | 1998-06-22 | Fremgangsmåde for tildeling af et vilkårligt beløb på en given taletidskortkonto | |
| US60/090,115 | 1998-06-22 | ||
| DKPA199800885 | 1998-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001101921A RU2001101921A (ru) | 2002-11-10 |
| RU2227916C2 true RU2227916C2 (ru) | 2004-04-27 |
Family
ID=26064838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001101921/15A RU2227916C2 (ru) | 1998-06-22 | 1999-06-22 | Количественный анализ для выявления присутствия неоплодотворяемых яйцеклеток |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20010028878A1 (ru) |
| EP (2) | EP1088056A1 (ru) |
| JP (1) | JP2002519640A (ru) |
| CN (2) | CN1161615C (ru) |
| AT (1) | ATE407363T1 (ru) |
| AU (2) | AU760165B2 (ru) |
| BR (1) | BR9911470A (ru) |
| CA (2) | CA2335793A1 (ru) |
| DE (1) | DE69939468D1 (ru) |
| EE (1) | EE200000763A (ru) |
| ES (1) | ES2313785T3 (ru) |
| HR (1) | HRP20000888A2 (ru) |
| HU (1) | HUP0103392A2 (ru) |
| ID (1) | ID27197A (ru) |
| IL (2) | IL140394A0 (ru) |
| IS (1) | IS5768A (ru) |
| NO (2) | NO20006519L (ru) |
| NZ (1) | NZ509451A (ru) |
| PL (1) | PL345318A1 (ru) |
| RU (1) | RU2227916C2 (ru) |
| SK (1) | SK19152000A3 (ru) |
| TR (1) | TR200003830T2 (ru) |
| WO (2) | WO1999067644A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005518823A (ja) * | 2002-03-08 | 2005-06-30 | マクギル・ユニバーシテイ | 未成熟ヒト卵母細胞の体外成熟 |
| JP2005529609A (ja) * | 2002-06-17 | 2005-10-06 | ケベンハウンス・アムツ・シゲフス・ハーレウ | 体外受精 |
| WO2005054449A1 (en) * | 2003-11-26 | 2005-06-16 | Applied Research Systems Ars Holding N.V. | Use of il-6-type cytokines for maturation of oocytes |
| WO2007008521A1 (en) * | 2005-07-07 | 2007-01-18 | Lonnie Shea | Stage specific follicle maturation systems |
| CN103275930B (zh) * | 2013-06-20 | 2014-07-09 | 江苏皓康生物医药科技有限公司 | 一种卵母细胞体外成熟培养液及其制备方法 |
| AU2015273531B2 (en) | 2014-06-10 | 2021-07-29 | Polybiocept Gmbh | Culture medium for cellular immunotherapy |
| WO2017143412A1 (en) * | 2016-02-24 | 2017-08-31 | Universidade Estadual Paulista "Júlioo De Mesquita Filho" - Unesp | Follicular system for in vitro oocyte maturation and kit |
| CN110628705A (zh) * | 2019-10-22 | 2019-12-31 | 山东畜牧兽医职业学院 | 一种驴胚胎冲洗液及其应用方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614715A (en) * | 1982-05-14 | 1986-09-30 | The Board Of Trustees Of The University Of Illinois | Predictive test for impending ovulation in mammals |
| WO1994004924A1 (en) * | 1992-08-21 | 1994-03-03 | Unipath Limited | Monitoring method |
| RU2013989C1 (ru) * | 1991-08-13 | 1994-06-15 | Борис Васильевич Леонов | Способ определения овуляции |
| WO1995016920A1 (en) * | 1993-12-16 | 1995-06-22 | Abbott Laboratories | Methods and means for determining the female fertile period |
| WO1997030175A1 (en) * | 1996-02-16 | 1997-08-21 | Royal Free Hospital School Of Medicine | Predictive assay for the outcome of ivf |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9410345D0 (en) * | 1994-05-24 | 1994-07-13 | Univ Oxford Brookes | Method of genetic testing |
| EP0833160B1 (en) * | 1996-09-27 | 2002-02-13 | Unilever Plc | Monitoring methods |
| GB9625175D0 (en) * | 1996-12-04 | 1997-01-22 | Medi Cult As | Serum-free cell culture media |
-
1999
- 1999-06-22 AU AU43604/99A patent/AU760165B2/en not_active Ceased
- 1999-06-22 EP EP99926294A patent/EP1088056A1/en not_active Withdrawn
- 1999-06-22 ES ES99926293T patent/ES2313785T3/es not_active Expired - Lifetime
- 1999-06-22 IL IL14039499A patent/IL140394A0/xx unknown
- 1999-06-22 WO PCT/DK1999/000344 patent/WO1999067644A1/en active IP Right Grant
- 1999-06-22 CN CNB998099309A patent/CN1161615C/zh not_active Expired - Fee Related
- 1999-06-22 CN CNA2004100489940A patent/CN1607391A/zh active Pending
- 1999-06-22 AU AU43605/99A patent/AU4360599A/en not_active Abandoned
- 1999-06-22 TR TR2000/03830T patent/TR200003830T2/xx unknown
- 1999-06-22 JP JP2000556250A patent/JP2002519640A/ja active Pending
- 1999-06-22 IL IL14028399A patent/IL140283A0/xx unknown
- 1999-06-22 AT AT99926293T patent/ATE407363T1/de not_active IP Right Cessation
- 1999-06-22 WO PCT/DK1999/000345 patent/WO1999067365A1/en not_active Application Discontinuation
- 1999-06-22 DE DE69939468T patent/DE69939468D1/de not_active Expired - Lifetime
- 1999-06-22 CA CA002335793A patent/CA2335793A1/en not_active Abandoned
- 1999-06-22 EP EP99926293A patent/EP1090300B1/en not_active Expired - Lifetime
- 1999-06-22 CA CA002335632A patent/CA2335632A1/en not_active Abandoned
- 1999-06-22 HU HU0103392A patent/HUP0103392A2/hu unknown
- 1999-06-22 ID IDW20010153A patent/ID27197A/id unknown
- 1999-06-22 PL PL99345318A patent/PL345318A1/xx not_active Application Discontinuation
- 1999-06-22 BR BR9911470-4A patent/BR9911470A/pt not_active IP Right Cessation
- 1999-06-22 RU RU2001101921/15A patent/RU2227916C2/ru not_active IP Right Cessation
- 1999-06-22 NZ NZ509451A patent/NZ509451A/xx not_active IP Right Cessation
- 1999-06-22 EE EEP200000763A patent/EE200000763A/xx unknown
- 1999-06-22 SK SK1915-2000A patent/SK19152000A3/sk unknown
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- 2000-12-12 IS IS5768A patent/IS5768A/is unknown
- 2000-12-20 NO NO20006519A patent/NO20006519L/no not_active Application Discontinuation
- 2000-12-20 HR HR20000888A patent/HRP20000888A2/hr not_active Application Discontinuation
- 2000-12-21 NO NO20006545A patent/NO20006545L/no not_active Application Discontinuation
- 2000-12-22 US US09/746,656 patent/US20010028878A1/en not_active Abandoned
- 2000-12-22 US US09/746,633 patent/US20020115211A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614715A (en) * | 1982-05-14 | 1986-09-30 | The Board Of Trustees Of The University Of Illinois | Predictive test for impending ovulation in mammals |
| RU2013989C1 (ru) * | 1991-08-13 | 1994-06-15 | Борис Васильевич Леонов | Способ определения овуляции |
| WO1994004924A1 (en) * | 1992-08-21 | 1994-03-03 | Unipath Limited | Monitoring method |
| WO1995016920A1 (en) * | 1993-12-16 | 1995-06-22 | Abbott Laboratories | Methods and means for determining the female fertile period |
| WO1997030175A1 (en) * | 1996-02-16 | 1997-08-21 | Royal Free Hospital School Of Medicine | Predictive assay for the outcome of ivf |
Non-Patent Citations (1)
| Title |
|---|
| FRANCHIMONT P et al. Correlation between follicular fluid content and the results of in vitro fertilization and embryo transfer. Inhibin and aromatase inhibition activity. J. Clin. Endocrinol. Metab. - 1990, Sep.71 (3), p.748-754, abstr. SUDIK R. et al. Human follicular fluid levels of endothelins in relation to oocyte maturity status. Exp. Clin. Endocrinol. Diabetes. - 1996, 104 (1), p.78-84, abstr. LOCKWOOD G.M. et al. Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in vitro fertilization-embryo transfer. Clin. Endocrinol (Oxf). - 1996, Dec. 45 (6), p.741-748, abstr. * |
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