AR063820A2 - Anticuerpo purificado y kit para detectar la prenez en un animal bovino - Google Patents

Anticuerpo purificado y kit para detectar la prenez en un animal bovino

Info

Publication number
AR063820A2
AR063820A2 ARP070105068A ARP070105068A AR063820A2 AR 063820 A2 AR063820 A2 AR 063820A2 AR P070105068 A ARP070105068 A AR P070105068A AR P070105068 A ARP070105068 A AR P070105068A AR 063820 A2 AR063820 A2 AR 063820A2
Authority
AR
Argentina
Prior art keywords
pag
animal
detection
kit
prenez
Prior art date
Application number
ARP070105068A
Other languages
English (en)
Inventor
Robert Michael Roberts
Jonathan Andrew Green
Sancai Xie
Original Assignee
Univ Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri filed Critical Univ Missouri
Publication of AR063820A2 publication Critical patent/AR063820A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/471—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Se provee un método para detectar la prenez en un animal euterio que comprende la obtención de una muestra del animal; y la detección de por lo menos uno de los antígenos asociados con la prenez (PAG), caracterizado porque el PAG está presente al comienzo de la prenez y ausente a los dos meses de post-parición aproximadamente, con lo cual la presencia de la PAG indica que el animal está prenado. La PAG se puede seleccionar del grupo formado por PAG2, PAG4, PAG5, PAG6, PAG7 y PAG9. En realizaciones más preferidas, la PAG puede ser, independientemente, BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG7v, boPAG9v, boPAG15, boPAG16; boPAG17; boPAG18; boPAG19; boPAG20 o boPAG21 y la muestra puede ser de saliva, suero, sangre, leche u orina. La detección comprende una detección inmunológica. También se contempla un método para elaborar un anticuerpo monoclonal contra BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG7v; boPAG9v; boPAG15; boPAG16; boPAG17, boPAG18, boPAG19; boPAG20 o boPAG21. Se provee también un método para identificar una glicoproteína asociada con la prenez (PAG) que es un indicador temprano de prenez en un animal euterio. Se describen asimismo los polipéptidos PAG y los ácidos nucleicos que los codifican. También se contemplan oligonucleótidos que comprenden por lo menos 15 pares de bases consecutivas de cualquier secuencia que codifica PAG, o un complemento de la misma. Se provee además un kit [juego] para llevar a cabo dicho método.
ARP070105068A 1998-03-20 2007-11-14 Anticuerpo purificado y kit para detectar la prenez en un animal bovino AR063820A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7878398P 1998-03-20 1998-03-20
US10618898P 1998-10-28 1998-10-28

Publications (1)

Publication Number Publication Date
AR063820A2 true AR063820A2 (es) 2009-02-18

Family

ID=26760935

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP990101227A AR015549A1 (es) 1998-03-20 1999-03-19 Método para inferir la prenez en un animal bovino.
ARP070105068A AR063820A2 (es) 1998-03-20 2007-11-14 Anticuerpo purificado y kit para detectar la prenez en un animal bovino
ARP100100469A AR075511A2 (es) 1998-03-20 2010-02-17 Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990101227A AR015549A1 (es) 1998-03-20 1999-03-19 Método para inferir la prenez en un animal bovino.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP100100469A AR075511A2 (es) 1998-03-20 2010-02-17 Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican

Country Status (7)

Country Link
US (4) US6869770B1 (es)
EP (2) EP2295978A3 (es)
AR (3) AR015549A1 (es)
AU (1) AU768018C (es)
CA (1) CA2323812C (es)
NZ (1) NZ507033A (es)
WO (1) WO1999047934A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113960025A (zh) * 2021-10-12 2022-01-21 北京农学院 一种奶牛早期妊娠的检测方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ507033A (en) 1998-03-20 2004-06-25 Univ Missouri Compositions and methods for early pregnancy diagnosis
PT1410012E (pt) * 2001-06-19 2013-02-28 Idaho Res Foundation Determinação do estado de gestação
WO2003028582A2 (en) 2001-09-28 2003-04-10 Aspenbio, Inc. Bovine pregnancy test
EP1468288A4 (en) * 2001-11-20 2006-03-15 Univ Missouri COMPOSITIONS AND METHODS FOR PRECISE PRECISE DIAGNOSIS OF PREGNANCY
US7842513B2 (en) 2002-05-02 2010-11-30 Aspenbio Pharma, Inc. Pregnancy detection
EP1756584B1 (en) * 2004-04-29 2012-08-01 Monsanto Technology LLC Enriched pag-55-60 fraction and methods for early detection of pregnancy in ungulate animals
US20080026384A1 (en) * 2005-09-30 2008-01-31 Hansen Thomas R Methods and compositions for the detection of bovine pregnancy
AU2008334976B2 (en) * 2007-12-13 2013-05-23 Monsanto Technology Llc Compositions and methods for early pregnancy diagnosis
WO2009126889A1 (en) * 2008-04-10 2009-10-15 The Curators Of The University Of Missouri Assays for detecting pregnancy- associated glycoproteins
US8541187B2 (en) 2011-03-01 2013-09-24 Bio Tracking, LLC Systems and methods for detecting animal pregnancy
US20190002978A1 (en) * 2016-01-11 2019-01-03 University Of Tennessee Research Foundation Pregnancy associated glycoprotein (pag) genes as markers of bull fertility
KR102189893B1 (ko) * 2017-11-15 2020-12-11 (주)에스엘에스바이오 bPAG1에 특이적으로 결합하는 항체 및 이의 용도
CN111596073B (zh) * 2020-06-04 2023-05-02 昆明天沃生物科技有限公司 一种检测羊早期妊娠的方法
KR20230065047A (ko) * 2021-11-04 2023-05-11 주식회사 나노바이오라이프 소 임신 진단 항체와 이를 이용한 조기 임신 진단키트 개발
CN114134123B (zh) * 2021-12-02 2023-05-05 深圳市爱医生物科技有限公司 妊娠相关糖蛋白的单克隆抗体及其在牛早期怀孕检测中的应用
CN114047336A (zh) * 2021-12-13 2022-02-15 大连医科大学 一种用于辅助诊断复发性流产的生物标志物及其应用
CN117820434A (zh) * 2023-12-31 2024-04-05 武汉优恩生物科技有限公司 牛羊妊娠相关糖蛋白的多肽抗原及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113960025A (zh) * 2021-10-12 2022-01-21 北京农学院 一种奶牛早期妊娠的检测方法

Also Published As

Publication number Publication date
CA2323812C (en) 2011-05-10
AR075511A2 (es) 2011-04-06
EP2295978A3 (en) 2012-06-06
AR015549A1 (es) 2001-05-02
US20100331206A1 (en) 2010-12-30
US6869770B1 (en) 2005-03-22
US20050100975A1 (en) 2005-05-12
AU768018B2 (en) 2003-11-27
AU3102899A (en) 1999-10-11
NZ507033A (en) 2004-06-25
US20070166773A1 (en) 2007-07-19
CA2323812A1 (en) 1999-09-23
WO1999047934A2 (en) 1999-09-23
US7763432B2 (en) 2010-07-27
EP2295978A2 (en) 2011-03-16
US8182999B2 (en) 2012-05-22
WO1999047934A3 (en) 2001-07-19
AU768018C (en) 2004-09-30
EP1141727A2 (en) 2001-10-10

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