AR063820A2 - Anticuerpo purificado y kit para detectar la prenez en un animal bovino - Google Patents
Anticuerpo purificado y kit para detectar la prenez en un animal bovinoInfo
- Publication number
- AR063820A2 AR063820A2 ARP070105068A ARP070105068A AR063820A2 AR 063820 A2 AR063820 A2 AR 063820A2 AR P070105068 A ARP070105068 A AR P070105068A AR P070105068 A ARP070105068 A AR P070105068A AR 063820 A2 AR063820 A2 AR 063820A2
- Authority
- AR
- Argentina
- Prior art keywords
- pag
- animal
- detection
- kit
- prenez
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 3
- 230000035935 pregnancy Effects 0.000 abstract 3
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 101100380306 Homo sapiens ASAP1 gene Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 101150003633 PAG2 gene Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/471—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Se provee un método para detectar la prenez en un animal euterio que comprende la obtención de una muestra del animal; y la detección de por lo menos uno de los antígenos asociados con la prenez (PAG), caracterizado porque el PAG está presente al comienzo de la prenez y ausente a los dos meses de post-parición aproximadamente, con lo cual la presencia de la PAG indica que el animal está prenado. La PAG se puede seleccionar del grupo formado por PAG2, PAG4, PAG5, PAG6, PAG7 y PAG9. En realizaciones más preferidas, la PAG puede ser, independientemente, BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG7v, boPAG9v, boPAG15, boPAG16; boPAG17; boPAG18; boPAG19; boPAG20 o boPAG21 y la muestra puede ser de saliva, suero, sangre, leche u orina. La detección comprende una detección inmunológica. También se contempla un método para elaborar un anticuerpo monoclonal contra BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG7v; boPAG9v; boPAG15; boPAG16; boPAG17, boPAG18, boPAG19; boPAG20 o boPAG21. Se provee también un método para identificar una glicoproteína asociada con la prenez (PAG) que es un indicador temprano de prenez en un animal euterio. Se describen asimismo los polipéptidos PAG y los ácidos nucleicos que los codifican. También se contemplan oligonucleótidos que comprenden por lo menos 15 pares de bases consecutivas de cualquier secuencia que codifica PAG, o un complemento de la misma. Se provee además un kit [juego] para llevar a cabo dicho método.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7878398P | 1998-03-20 | 1998-03-20 | |
US10618898P | 1998-10-28 | 1998-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063820A2 true AR063820A2 (es) | 2009-02-18 |
Family
ID=26760935
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990101227A AR015549A1 (es) | 1998-03-20 | 1999-03-19 | Método para inferir la prenez en un animal bovino. |
ARP070105068A AR063820A2 (es) | 1998-03-20 | 2007-11-14 | Anticuerpo purificado y kit para detectar la prenez en un animal bovino |
ARP100100469A AR075511A2 (es) | 1998-03-20 | 2010-02-17 | Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990101227A AR015549A1 (es) | 1998-03-20 | 1999-03-19 | Método para inferir la prenez en un animal bovino. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100469A AR075511A2 (es) | 1998-03-20 | 2010-02-17 | Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican |
Country Status (7)
Country | Link |
---|---|
US (4) | US6869770B1 (es) |
EP (2) | EP2295978A3 (es) |
AR (3) | AR015549A1 (es) |
AU (1) | AU768018C (es) |
CA (1) | CA2323812C (es) |
NZ (1) | NZ507033A (es) |
WO (1) | WO1999047934A2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113960025A (zh) * | 2021-10-12 | 2022-01-21 | 北京农学院 | 一种奶牛早期妊娠的检测方法 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ507033A (en) | 1998-03-20 | 2004-06-25 | Univ Missouri | Compositions and methods for early pregnancy diagnosis |
PT1410012E (pt) * | 2001-06-19 | 2013-02-28 | Idaho Res Foundation | Determinação do estado de gestação |
WO2003028582A2 (en) | 2001-09-28 | 2003-04-10 | Aspenbio, Inc. | Bovine pregnancy test |
EP1468288A4 (en) * | 2001-11-20 | 2006-03-15 | Univ Missouri | COMPOSITIONS AND METHODS FOR PRECISE PRECISE DIAGNOSIS OF PREGNANCY |
US7842513B2 (en) | 2002-05-02 | 2010-11-30 | Aspenbio Pharma, Inc. | Pregnancy detection |
EP1756584B1 (en) * | 2004-04-29 | 2012-08-01 | Monsanto Technology LLC | Enriched pag-55-60 fraction and methods for early detection of pregnancy in ungulate animals |
US20080026384A1 (en) * | 2005-09-30 | 2008-01-31 | Hansen Thomas R | Methods and compositions for the detection of bovine pregnancy |
AU2008334976B2 (en) * | 2007-12-13 | 2013-05-23 | Monsanto Technology Llc | Compositions and methods for early pregnancy diagnosis |
WO2009126889A1 (en) * | 2008-04-10 | 2009-10-15 | The Curators Of The University Of Missouri | Assays for detecting pregnancy- associated glycoproteins |
US8541187B2 (en) | 2011-03-01 | 2013-09-24 | Bio Tracking, LLC | Systems and methods for detecting animal pregnancy |
US20190002978A1 (en) * | 2016-01-11 | 2019-01-03 | University Of Tennessee Research Foundation | Pregnancy associated glycoprotein (pag) genes as markers of bull fertility |
KR102189893B1 (ko) * | 2017-11-15 | 2020-12-11 | (주)에스엘에스바이오 | bPAG1에 특이적으로 결합하는 항체 및 이의 용도 |
CN111596073B (zh) * | 2020-06-04 | 2023-05-02 | 昆明天沃生物科技有限公司 | 一种检测羊早期妊娠的方法 |
KR20230065047A (ko) * | 2021-11-04 | 2023-05-11 | 주식회사 나노바이오라이프 | 소 임신 진단 항체와 이를 이용한 조기 임신 진단키트 개발 |
CN114134123B (zh) * | 2021-12-02 | 2023-05-05 | 深圳市爱医生物科技有限公司 | 妊娠相关糖蛋白的单克隆抗体及其在牛早期怀孕检测中的应用 |
CN114047336A (zh) * | 2021-12-13 | 2022-02-15 | 大连医科大学 | 一种用于辅助诊断复发性流产的生物标志物及其应用 |
CN117820434A (zh) * | 2023-12-31 | 2024-04-05 | 武汉优恩生物科技有限公司 | 牛羊妊娠相关糖蛋白的多肽抗原及应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
US4271140A (en) * | 1978-01-23 | 1981-06-02 | Baxter Travenol Laboratories, Inc. | Method and composition for double receptor, specific binding assays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4367110A (en) | 1979-07-02 | 1983-01-04 | Toppan Printing Co. | Decorative laminate and a manufacturing method therefor |
US4452901A (en) | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4755460A (en) * | 1984-07-06 | 1988-07-05 | The Regents Of The Univ. Of Minnesota | Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle |
US4895804A (en) * | 1984-07-06 | 1990-01-23 | University Of Minnesota | Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4668621A (en) | 1985-04-22 | 1987-05-26 | Wake Forest University | Detecting blood clotting factors with immobilized fibrinogen and labeled fibrinogen |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US4932207A (en) | 1988-12-28 | 1990-06-12 | Sundstrand Corporation | Segmented seal plate for a turbine engine |
DE19733505A1 (de) | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
NZ534553A (en) * | 1998-02-02 | 2006-04-28 | Concepto Diagnostics Inc | Antibodies specific for early conception factor and methods for detecting conception in animals |
NZ507033A (en) | 1998-03-20 | 2004-06-25 | Univ Missouri | Compositions and methods for early pregnancy diagnosis |
WO2003028582A2 (en) | 2001-09-28 | 2003-04-10 | Aspenbio, Inc. | Bovine pregnancy test |
EP1468288A4 (en) | 2001-11-20 | 2006-03-15 | Univ Missouri | COMPOSITIONS AND METHODS FOR PRECISE PRECISE DIAGNOSIS OF PREGNANCY |
WO2009126889A1 (en) | 2008-04-10 | 2009-10-15 | The Curators Of The University Of Missouri | Assays for detecting pregnancy- associated glycoproteins |
-
1999
- 1999-03-19 NZ NZ507033A patent/NZ507033A/en not_active IP Right Cessation
- 1999-03-19 CA CA2323812A patent/CA2323812C/en not_active Expired - Lifetime
- 1999-03-19 AU AU31028/99A patent/AU768018C/en not_active Expired
- 1999-03-19 EP EP10183539A patent/EP2295978A3/en not_active Withdrawn
- 1999-03-19 AR ARP990101227A patent/AR015549A1/es active IP Right Grant
- 1999-03-19 US US09/273,164 patent/US6869770B1/en not_active Expired - Lifetime
- 1999-03-19 EP EP99912715A patent/EP1141727A2/en not_active Withdrawn
- 1999-03-19 WO PCT/US1999/006038 patent/WO1999047934A2/en active IP Right Grant
-
2003
- 2003-09-04 US US10/655,547 patent/US20050100975A1/en not_active Abandoned
-
2006
- 2006-10-24 US US11/552,454 patent/US7763432B2/en not_active Expired - Fee Related
-
2007
- 2007-11-14 AR ARP070105068A patent/AR063820A2/es not_active Application Discontinuation
-
2010
- 2010-02-17 AR ARP100100469A patent/AR075511A2/es active IP Right Grant
- 2010-06-28 US US12/825,223 patent/US8182999B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113960025A (zh) * | 2021-10-12 | 2022-01-21 | 北京农学院 | 一种奶牛早期妊娠的检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2323812C (en) | 2011-05-10 |
AR075511A2 (es) | 2011-04-06 |
EP2295978A3 (en) | 2012-06-06 |
AR015549A1 (es) | 2001-05-02 |
US20100331206A1 (en) | 2010-12-30 |
US6869770B1 (en) | 2005-03-22 |
US20050100975A1 (en) | 2005-05-12 |
AU768018B2 (en) | 2003-11-27 |
AU3102899A (en) | 1999-10-11 |
NZ507033A (en) | 2004-06-25 |
US20070166773A1 (en) | 2007-07-19 |
CA2323812A1 (en) | 1999-09-23 |
WO1999047934A2 (en) | 1999-09-23 |
US7763432B2 (en) | 2010-07-27 |
EP2295978A2 (en) | 2011-03-16 |
US8182999B2 (en) | 2012-05-22 |
WO1999047934A3 (en) | 2001-07-19 |
AU768018C (en) | 2004-09-30 |
EP1141727A2 (en) | 2001-10-10 |
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