RU2188011C2 - Активирующая остеогенез фармацевтическая композиция - Google Patents

Активирующая остеогенез фармацевтическая композиция Download PDF

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Publication number
RU2188011C2
RU2188011C2 RU98100111/14A RU98100111A RU2188011C2 RU 2188011 C2 RU2188011 C2 RU 2188011C2 RU 98100111/14 A RU98100111/14 A RU 98100111/14A RU 98100111 A RU98100111 A RU 98100111A RU 2188011 C2 RU2188011 C2 RU 2188011C2
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RU
Russia
Prior art keywords
pharmaceutical composition
acid
composition according
copolymer
compound
Prior art date
Application number
RU98100111/14A
Other languages
English (en)
Russian (ru)
Other versions
RU98100111A (ru
Inventor
Тецуо ХОСИНО (JP)
Тецуо Хосино
Хиро МУРАНИСИ (JP)
Хироя МУРАНИСИ
Сигехиза ТАКЕТОМИ (JP)
Сигехиза ТАКЕТОМИ
Сузуми ИВАСА (JP)
Сузуми ИВАСА
Original Assignee
Такеда Кемикал Индастриз, Лтд.
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Publication date
Application filed by Такеда Кемикал Индастриз, Лтд. filed Critical Такеда Кемикал Индастриз, Лтд.
Publication of RU98100111A publication Critical patent/RU98100111A/ru
Application granted granted Critical
Publication of RU2188011C2 publication Critical patent/RU2188011C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
RU98100111/14A 1995-06-05 1996-06-04 Активирующая остеогенез фармацевтическая композиция RU2188011C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7/138036 1995-06-05
JP13803695 1995-06-05
JP8/011686 1996-01-26
JP1168696 1996-01-26

Publications (2)

Publication Number Publication Date
RU98100111A RU98100111A (ru) 2000-01-27
RU2188011C2 true RU2188011C2 (ru) 2002-08-27

Family

ID=26347166

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98100111/14A RU2188011C2 (ru) 1995-06-05 1996-06-04 Активирующая остеогенез фармацевтическая композиция

Country Status (11)

Country Link
EP (1) EP0831808A1 (zh)
KR (1) KR19990022514A (zh)
AR (1) AR003001A1 (zh)
AU (1) AU717260B2 (zh)
CA (1) CA2221784A1 (zh)
HU (1) HUP9802573A3 (zh)
NO (1) NO975636L (zh)
NZ (1) NZ308658A (zh)
RU (1) RU2188011C2 (zh)
TW (1) TW420608B (zh)
WO (1) WO1996039134A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0949927B1 (en) 1996-08-26 2002-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
WO1999065474A2 (en) * 1998-06-15 1999-12-23 Takeda Chemical Industries, Ltd. Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds
US6355672B1 (en) 1998-08-07 2002-03-12 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
WO2000009100A2 (en) * 1998-08-12 2000-02-24 Takeda Chemical Industries, Ltd. Benzothiepine compounds as enhancer of cell differentiation induction factor
WO2001089521A1 (fr) * 2000-05-23 2001-11-29 Takeda Chemical Industries, Ltd. Compositions medicinales contenant des derives du tiophene
US6926903B2 (en) 2001-12-04 2005-08-09 Inion Ltd. Resorbable polymer composition, implant and method of making implant
JP4723864B2 (ja) * 2002-12-19 2011-07-13 日本曹達株式会社 Ｏｉｌ／Ｗａｔｅｒ液中乾燥法による農薬マイクロカプセル製剤及びその製造方法
US9814657B2 (en) 2009-04-27 2017-11-14 Premier Dental Products Company Buffered microencapsulated compositions and methods
US8889161B2 (en) 2009-04-27 2014-11-18 Premier Dental Products Company Microencapsulated compositions and methods for tissue mineralization
TWI458503B (zh) * 2013-04-22 2014-11-01 Medical & Pharm Ind Tech & Dev 維生素ｋ微球、其製造方法、用途、及藥劑

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157887T3 (es) * 1990-05-30 2001-09-01 Takeda Chemical Industries Ltd Compuestos heterociclicos que contienen azufre.
CN1151744A (zh) * 1994-07-04 1997-06-11 武田药品工业株式会社 膦酸化合物及其制备和应用
TW403757B (en) * 1994-12-28 2000-09-01 Takeda Chemical Industries Ltd Optically active benzothiepin derivative, its preparation and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NELSAI at ab "Evaluation and Comparisone of biodegrecdable substance as osteogenic Agents". B: "Oral surgery, oral medicin, oral pathology", 1977, v. 43, №6, p.836-843. Polylactic acid-polyethylene glycol block polymer B: "Clin orth. and Rel. Research", 1993, v. 294, p.333. *

Also Published As

Publication number Publication date
EP0831808A1 (en) 1998-04-01
HUP9802573A3 (en) 2000-04-28
NO975636L (no) 1998-01-28
HUP9802573A2 (hu) 1999-09-28
TW420608B (en) 2001-02-01
KR19990022514A (ko) 1999-03-25
CA2221784A1 (en) 1996-12-12
AU717260B2 (en) 2000-03-23
NO975636D0 (no) 1997-12-04
AU5845796A (en) 1996-12-24
NZ308658A (en) 1999-10-28
WO1996039134A1 (en) 1996-12-12
AR003001A1 (es) 1998-05-27

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20030605