RU2177950C2 - Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) - Google Patents

Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) Download PDF

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RU2177950C2
RU2177950C2 RU99110377/04A RU99110377A RU2177950C2 RU 2177950 C2 RU2177950 C2 RU 2177950C2 RU 99110377/04 A RU99110377/04 A RU 99110377/04A RU 99110377 A RU99110377 A RU 99110377A RU 2177950 C2 RU2177950 C2 RU 2177950C2
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vegf
complex
ligand
nucleic acid
lipid
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RU99110377/04A
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English (en)
Russian (ru)
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RU99110377A (ru
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Небоджса ДЖЕНДЖИК
Лэрри Голд
Пол Дж. ШМИДТ
Чэндра ВАРДЖИЗ
Майкл УИЛЛИС
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Нексстар Фармасьютикалз, Инк.
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Priority claimed from US08/739,109 external-priority patent/US5859228A/en
Priority claimed from US08/870,930 external-priority patent/US6168778B1/en
Priority claimed from US08/897,351 external-priority patent/US6051698A/en
Application filed by Нексстар Фармасьютикалз, Инк. filed Critical Нексстар Фармасьютикалз, Инк.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Proteomics, Peptides & Aminoacids (AREA)
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RU99110377/04A 1996-10-25 1997-10-17 Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) RU2177950C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/739,109 1996-10-25
US08/739,109 US5859228A (en) 1995-05-04 1996-10-25 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/870,930 US6168778B1 (en) 1990-06-11 1997-06-06 Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US08/870,930 1997-06-06
US08/897,351 US6051698A (en) 1997-06-06 1997-07-21 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/897,351 1997-07-21

Publications (2)

Publication Number Publication Date
RU99110377A RU99110377A (ru) 2001-02-27
RU2177950C2 true RU2177950C2 (ru) 2002-01-10

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RU99110377/04A RU2177950C2 (ru) 1996-10-25 1997-10-17 Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf)

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EP (2) EP1685842A3 (https=)
JP (2) JP3626503B2 (https=)
KR (1) KR100514929B1 (https=)
AT (1) ATE318143T1 (https=)
AU (1) AU733674B2 (https=)
CA (1) CA2269072C (https=)
DE (3) DE122006000029I1 (https=)
DK (1) DK0957929T3 (https=)
ES (1) ES2259188T3 (https=)
FR (1) FR06C0021I2 (https=)
GE (1) GEP20094799B (https=)
IL (2) IL129497A0 (https=)
LU (1) LU91252I2 (https=)
NL (1) NL300234I2 (https=)
NZ (1) NZ334859A (https=)
PT (1) PT957929E (https=)
RU (1) RU2177950C2 (https=)
WO (1) WO1998018480A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2234097C1 (ru) * 2003-03-05 2004-08-10 Московский областной научно-исследовательский клинический институт Способ диагностики саркомы капоши
RU2318004C2 (ru) * 2002-07-24 2008-02-27 Ф.Хоффманн-Ля Рош Аг Добавки в виде полиалкиленгликолевой кислоты
RU2318019C2 (ru) * 2002-03-02 2008-02-27 Дзе Скриппс Рисерч Инститьют Днк-вакцина против пролиферирующих эндотелиальных клеток и способы ее применения
RU2376373C2 (ru) * 2003-06-30 2009-12-20 Ридженерон Фармасьютикалз, Инк. Изолированная молекула нуклеиновой кислоты, кодирующая слитый полипептид, способный связывать фактор роста эндотелиальных клеток сосудов (vegf), слитый полипептид, реплицируемый экспрессионный вектор, способ получения слитого полипептида, ловушка vegf, фармацевтическая композиция, способ лечения и набор для лечения vegf-опосредованного заболевания или состояния
EA013878B1 (ru) * 2005-12-06 2010-08-30 Домантис Лимитед Лиганды, имеющие специфичность связывания в отношении рецептора эпидермального фактора роста (egfr) и/или сосудистого эндотелиального фактора роста (vegf), и способы их применения
RU2569182C2 (ru) * 2008-12-04 2015-11-20 КьюРНА,Инк.,US Лечение заболеваний, связанных с фактором роста эндотелия сосудов (vegf), посредством ингибирования природного антисмыслового транскрипта к vegf

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US6346611B1 (en) * 1990-06-11 2002-02-12 Gilead Sciences, Inc. High affinity TGfβ nucleic acid ligands and inhibitors
US6762290B1 (en) * 1999-07-29 2004-07-13 Gilead Sciences, Inc. High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors
AU782620B2 (en) * 1991-06-10 2005-08-11 Gilead Sciences, Inc. High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors
DK1198490T3 (da) * 1999-07-14 2006-06-19 Alza Corp Neutral lipopolymer og liposomsammensætninger indeholdende samme
US7312325B2 (en) * 2000-09-26 2007-12-25 Duke University RNA aptamers and methods for identifying the same
ATE469164T1 (de) * 2001-10-26 2010-06-15 Noxxon Pharma Ag Modifizierte l-nukleinsäure
JP2005511576A (ja) * 2001-11-09 2005-04-28 アイテック・ファーマシューティカルズ 眼球血管新生病を治療する方法
US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
ATE516366T1 (de) 2002-07-25 2011-07-15 Archemix Corp Regulierte aptamer-therapeutika
US9303262B2 (en) 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8039443B2 (en) 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
AU2003297682A1 (en) * 2002-12-03 2004-06-23 Archemix Corporation Method for in vitro selection of 2'-substituted nucleic acids
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
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US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
HUE038239T2 (hu) 2004-02-12 2018-10-29 Archemix Llc Komplementrendszerrel összefüggõ rendellenességek kezelésében alkalmazható aptamer terapeutikumok
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EP2436391A3 (en) 2004-11-02 2012-07-04 Archemix LLC Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
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KR100877824B1 (ko) 2005-11-11 2009-01-12 한국생명공학연구원 Ｅ2ｅｐｆ ｕｃｐ-ｖｈｌ 상호작용 및 그 용도
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