RU2177950C2 - Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) - Google Patents

Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) Download PDF

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RU2177950C2
RU2177950C2 RU99110377/04A RU99110377A RU2177950C2 RU 2177950 C2 RU2177950 C2 RU 2177950C2 RU 99110377/04 A RU99110377/04 A RU 99110377/04A RU 99110377 A RU99110377 A RU 99110377A RU 2177950 C2 RU2177950 C2 RU 2177950C2
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vegf
complex
ligand
nucleic acid
lipid
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RU99110377/04A
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English (en)
Russian (ru)
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RU99110377A (ru
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Небоджса ДЖЕНДЖИК
Лэрри Голд
Пол Дж. ШМИДТ
Чэндра ВАРДЖИЗ
Майкл УИЛЛИС
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Нексстар Фармасьютикалз, Инк.
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Priority claimed from US08/739,109 external-priority patent/US5859228A/en
Priority claimed from US08/870,930 external-priority patent/US6168778B1/en
Priority claimed from US08/897,351 external-priority patent/US6051698A/en
Application filed by Нексстар Фармасьютикалз, Инк. filed Critical Нексстар Фармасьютикалз, Инк.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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RU99110377/04A 1996-10-25 1997-10-17 Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) RU2177950C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/739,109 1996-10-25
US08/739,109 US5859228A (en) 1995-05-04 1996-10-25 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/870,930 US6168778B1 (en) 1990-06-11 1997-06-06 Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US08/870,930 1997-06-06
US08/897,351 1997-07-21
US08/897,351 US6051698A (en) 1997-06-06 1997-07-21 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes

Publications (2)

Publication Number Publication Date
RU99110377A RU99110377A (ru) 2001-02-27
RU2177950C2 true RU2177950C2 (ru) 2002-01-10

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RU99110377/04A RU2177950C2 (ru) 1996-10-25 1997-10-17 Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf)

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EP (2) EP1685842A3 (https=)
JP (2) JP3626503B2 (https=)
KR (1) KR100514929B1 (https=)
AT (1) ATE318143T1 (https=)
AU (1) AU733674B2 (https=)
CA (1) CA2269072C (https=)
DE (3) DE69735292T2 (https=)
DK (1) DK0957929T3 (https=)
ES (1) ES2259188T3 (https=)
FR (1) FR06C0021I2 (https=)
GE (1) GEP20094799B (https=)
IL (2) IL129497A0 (https=)
LU (1) LU91252I2 (https=)
NL (1) NL300234I2 (https=)
NZ (1) NZ334859A (https=)
PT (1) PT957929E (https=)
RU (1) RU2177950C2 (https=)
WO (1) WO1998018480A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2234097C1 (ru) * 2003-03-05 2004-08-10 Московский областной научно-исследовательский клинический институт Способ диагностики саркомы капоши
RU2318019C2 (ru) * 2002-03-02 2008-02-27 Дзе Скриппс Рисерч Инститьют Днк-вакцина против пролиферирующих эндотелиальных клеток и способы ее применения
RU2318004C2 (ru) * 2002-07-24 2008-02-27 Ф.Хоффманн-Ля Рош Аг Добавки в виде полиалкиленгликолевой кислоты
RU2376373C2 (ru) * 2003-06-30 2009-12-20 Ридженерон Фармасьютикалз, Инк. Изолированная молекула нуклеиновой кислоты, кодирующая слитый полипептид, способный связывать фактор роста эндотелиальных клеток сосудов (vegf), слитый полипептид, реплицируемый экспрессионный вектор, способ получения слитого полипептида, ловушка vegf, фармацевтическая композиция, способ лечения и набор для лечения vegf-опосредованного заболевания или состояния
EA013878B1 (ru) * 2005-12-06 2010-08-30 Домантис Лимитед Лиганды, имеющие специфичность связывания в отношении рецептора эпидермального фактора роста (egfr) и/или сосудистого эндотелиального фактора роста (vegf), и способы их применения
RU2569182C2 (ru) * 2008-12-04 2015-11-20 КьюРНА,Инк.,US Лечение заболеваний, связанных с фактором роста эндотелия сосудов (vegf), посредством ингибирования природного антисмыслового транскрипта к vegf

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US6762290B1 (en) 1999-07-29 2004-07-13 Gilead Sciences, Inc. High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors
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US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
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