KR100514929B1 - 혈관내피 성장인자 핵산 리간드 복합체 - Google Patents
혈관내피 성장인자 핵산 리간드 복합체 Download PDFInfo
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- KR100514929B1 KR100514929B1 KR10-1999-7003488A KR19997003488A KR100514929B1 KR 100514929 B1 KR100514929 B1 KR 100514929B1 KR 19997003488 A KR19997003488 A KR 19997003488A KR 100514929 B1 KR100514929 B1 KR 100514929B1
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/739,109 | 1996-10-25 | ||
| US08/739,109 US5859228A (en) | 1995-05-04 | 1996-10-25 | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| US8/739,109 | 1996-10-25 | ||
| US08/870,930 US6168778B1 (en) | 1990-06-11 | 1997-06-06 | Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes |
| US08/870,930 | 1997-06-06 | ||
| US8/870,930 | 1997-06-06 | ||
| US08/897,351 | 1997-07-21 | ||
| US08/897,351 US6051698A (en) | 1997-06-06 | 1997-07-21 | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| US8/897,351 | 1997-07-21 |
Publications (2)
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| KR20000052697A KR20000052697A (ko) | 2000-08-25 |
| KR100514929B1 true KR100514929B1 (ko) | 2005-09-15 |
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Families Citing this family (67)
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| US6346611B1 (en) | 1990-06-11 | 2002-02-12 | Gilead Sciences, Inc. | High affinity TGfβ nucleic acid ligands and inhibitors |
| US6232071B1 (en) * | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| US6395888B1 (en) | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
| AU782620B2 (en) * | 1991-06-10 | 2005-08-11 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
| US6762290B1 (en) | 1999-07-29 | 2004-07-13 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| KR100758158B1 (ko) | 1999-07-14 | 2007-09-12 | 알자 코포레이션 | 중성 지질중합체 및 그를 함유하는 리포솜 조성물 |
| US7312325B2 (en) * | 2000-09-26 | 2007-12-25 | Duke University | RNA aptamers and methods for identifying the same |
| US7629456B2 (en) * | 2001-10-26 | 2009-12-08 | Noxxon Pharma Ag | Modified L-nucleic acid |
| WO2003039404A2 (en) * | 2001-11-09 | 2003-05-15 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
| US7094410B2 (en) * | 2002-03-02 | 2006-08-22 | The Scripps Research Institute | DNA vaccine against proliferating endothelial cells and methods of use thereof |
| US7767803B2 (en) | 2002-06-18 | 2010-08-03 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
| WO2004012773A1 (en) * | 2002-07-24 | 2004-02-12 | F. Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
| JP2005533862A (ja) | 2002-07-25 | 2005-11-10 | アーケミックス コーポレイション | 調節されたアプタマー治療剤 |
| US9303262B2 (en) | 2002-09-17 | 2016-04-05 | Archemix Llc | Methods for identifying aptamer regulators |
| US8039443B2 (en) | 2002-11-21 | 2011-10-18 | Archemix Corporation | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US10100316B2 (en) | 2002-11-21 | 2018-10-16 | Archemix Llc | Aptamers comprising CPG motifs |
| US20040197804A1 (en) | 2002-12-03 | 2004-10-07 | Keefe Anthony D. | Method for in vitro selection of 2'-substituted nucleic acids |
| RU2234097C1 (ru) * | 2003-03-05 | 2004-08-10 | Московский областной научно-исследовательский клинический институт | Способ диагностики саркомы капоши |
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| EP2924119A1 (en) | 2003-04-21 | 2015-09-30 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| CL2004001996A1 (es) * | 2003-08-08 | 2005-05-06 | Eyetech Pharmaceuticals Inc | Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion. |
| PL3385384T3 (pl) | 2004-02-12 | 2021-03-08 | Archemix Llc | Aptamerowe środki terapeutyczne użyteczne w leczeniu zaburzeń powiązanych z dopełniaczem |
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| WO2005110489A2 (en) * | 2004-04-13 | 2005-11-24 | (Osi) Eyetech, Inc. | Nucleic acid aptamers conjugated to high molecular weight steric groups |
| US7579450B2 (en) | 2004-04-26 | 2009-08-25 | Archemix Corp. | Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| JP2008512097A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | アプタマー医薬品化学 |
| EP3034089A1 (en) | 2004-11-02 | 2016-06-22 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| KR20080025181A (ko) | 2005-06-30 | 2008-03-19 | 아케믹스 코포레이션 | 완전 2'-변형된 핵산 전사체를 생성하기 위한 물질 및 방법 |
| US8101385B2 (en) | 2005-06-30 | 2012-01-24 | Archemix Corp. | Materials and methods for the generation of transcripts comprising modified nucleotides |
| EP1912676A2 (en) * | 2005-07-28 | 2008-04-23 | (Osi) Eyetech, Inc. | Cyclitol linker polymer conjugate |
| ES2577514T3 (es) | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| KR100877824B1 (ko) | 2005-11-11 | 2009-01-12 | 한국생명공학연구원 | Ｅ2ｅｐｆ ｕｃｐ-ｖｈｌ 상호작용 및 그 용도 |
| JP2009518024A (ja) * | 2005-12-06 | 2009-05-07 | ドマンティス リミテッド | Ｅｇｆｒおよび／またはｖｅｇｆに対して結合特異性を有するリガンドおよびその使用法 |
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| WO2007080902A1 (ja) * | 2006-01-11 | 2007-07-19 | Kyowa Hakko Kogyo Co., Ltd. | 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤 |
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| EP0462145B1 (en) * | 1989-03-07 | 1994-04-27 | Genentech, Inc. | Covalent conjugates of lipid and oligonucleotide |
| US5459015A (en) * | 1990-06-11 | 1995-10-17 | Nexstar Pharmaceuticals, Inc. | High-affinity RNA ligands of basic fibroblast growth factor |
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| WO1996027604A1 (en) * | 1995-03-06 | 1996-09-12 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to secretory phospholipase a2(spla2) |
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| FR06C0021I2 (fr) | 2007-08-03 |
| JP4160038B2 (ja) | 2008-10-01 |
| EP0957929A4 (en) | 2003-06-25 |
| AU4990497A (en) | 1998-05-22 |
| NZ334859A (en) | 2001-02-23 |
| RU2177950C2 (ru) | 2002-01-10 |
| PT957929E (pt) | 2006-06-30 |
| JP2001505191A (ja) | 2001-04-17 |
| JP3626503B2 (ja) | 2005-03-09 |
| ES2259188T3 (es) | 2006-09-16 |
| EP1685842A3 (en) | 2006-11-29 |
| DE69735292T2 (de) | 2006-10-19 |
| EP0957929B1 (en) | 2006-02-22 |
| AU733674B2 (en) | 2001-05-24 |
| CA2269072C (en) | 2006-02-14 |
| LU91252I2 (fr) | 2006-08-14 |
| DE122006000029I1 (de) | 2006-10-19 |
| CA2269072A1 (en) | 1998-05-07 |
| NL300234I2 (nl) | 2006-10-02 |
| IL129497A0 (en) | 2000-02-29 |
| JP2005046160A (ja) | 2005-02-24 |
| DE122006000029I2 (de) | 2007-11-08 |
| IL129497A (en) | 2009-06-15 |
| EP0957929A1 (en) | 1999-11-24 |
| WO1998018480A1 (en) | 1998-05-07 |
| NL300234I1 (nl) | 2006-09-01 |
| GEP20094799B (en) | 2009-10-26 |
| KR20000052697A (ko) | 2000-08-25 |
| DE69735292D1 (de) | 2006-04-27 |
| DK0957929T3 (da) | 2006-07-03 |
| ATE318143T1 (de) | 2006-03-15 |
| EP1685842A2 (en) | 2006-08-02 |
| FR06C0021I1 (https=) | 2006-10-13 |
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