RU2120447C1 - ПРОИЗВОДНЫЕ β АМИНО α ГИДРОКСИКАРБОНОВЫХ КИСЛОТ ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ИЛИ ЭФИРОВ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ - Google Patents
ПРОИЗВОДНЫЕ β АМИНО α ГИДРОКСИКАРБОНОВЫХ КИСЛОТ ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ИЛИ ЭФИРОВ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ Download PDFInfo
- Publication number
- RU2120447C1 RU2120447C1 SU5011192A SU5011192A RU2120447C1 RU 2120447 C1 RU2120447 C1 RU 2120447C1 SU 5011192 A SU5011192 A SU 5011192A SU 5011192 A SU5011192 A SU 5011192A RU 2120447 C1 RU2120447 C1 RU 2120447C1
- Authority
- RU
- Russia
- Prior art keywords
- group
- amino
- hydroxy
- tert
- phenylbutyryl
- Prior art date
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- 0 CCC(C(C(*)CCC(C(*)N(*)*)=O)O)=O Chemical compound CCC(C(C(*)CCC(C(*)N(*)*)=O)O)=O 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1734191 | 1991-02-08 | ||
JP3-17341 | 1991-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2120447C1 true RU2120447C1 (ru) | 1998-10-20 |
Family
ID=11941358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU5011192A RU2120447C1 (ru) | 1991-02-08 | 1992-02-07 | ПРОИЗВОДНЫЕ β АМИНО α ГИДРОКСИКАРБОНОВЫХ КИСЛОТ ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ИЛИ ЭФИРОВ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0498680A1 (fr) |
KR (1) | KR920016417A (fr) |
CN (1) | CN1039321C (fr) |
AU (1) | AU647239B2 (fr) |
CA (1) | CA2060844A1 (fr) |
CS (1) | CS35692A3 (fr) |
HU (2) | HUT60282A (fr) |
IE (1) | IE920414A1 (fr) |
IL (1) | IL100899A (fr) |
RU (1) | RU2120447C1 (fr) |
TW (1) | TW304197B (fr) |
ZA (1) | ZA92913B (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6313094B1 (en) | 1990-12-11 | 2001-11-06 | Japan Energy Corporation | β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors |
ZA929869B (en) * | 1991-12-20 | 1994-06-20 | Syntex Inc | Hiv protease inhibitors |
RU2126794C1 (ru) * | 1992-03-11 | 1999-02-27 | Нархекс Лимитед | Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы |
US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
DE69322127T2 (de) * | 1992-05-13 | 1999-06-24 | Japan Energy Corp | Verfahren zur Herstellung von Peptidderivaten und ihrer Salze |
US5644028A (en) * | 1992-05-13 | 1997-07-01 | Japan Energy Corporation | Process for producing peptide derivatives and salts therefor |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
ZA935697B (en) * | 1992-08-07 | 1994-03-10 | Sankyo Co | Peptides capable of inhibiting the activity of hiv protease their preparation and their therapeutic use |
US5733906A (en) * | 1993-10-12 | 1998-03-31 | Eli Lilly And Company | Inhibitors of HIV Protease useful for the treatment of Aids |
US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
HUT74685A (en) * | 1994-02-02 | 1997-01-28 | Lilly Co Eli | Hiv protease inhibitors and intermediates piperidine derivatives condensed with heterocycles as intermediates for hiv protease inhibitors |
US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
EP0706794B1 (fr) * | 1994-10-14 | 2001-12-12 | Japan Energy Corporation | Composition pharmaceutique anti-SIDA et procédé de préparation |
CA2179935C (fr) * | 1995-06-30 | 2010-09-07 | Ryohei Kato | Compose dipeptidique ou sel de ce dernier acceptable en pharmacie; utilisation en medecine |
US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
CA2249747A1 (fr) * | 1996-12-27 | 1998-07-09 | Tsutomu Mimoto | Nouveaux composes de tripeptides et medicaments anti-sida |
JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び/又は治療剤 |
US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
WO1998041230A1 (fr) | 1997-03-14 | 1998-09-24 | Snow Brand Milk Products Co., Ltd. | Agent preventif et/ou curatif de la cachexie |
US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
EP1389111A1 (fr) | 2001-04-09 | 2004-02-18 | Republic of Korea | Composition permettant d'inhiber l'activite de vih contenant un extrait de paecilomyces sp. (tochu-kaso) j300 |
US7169932B2 (en) | 2001-06-11 | 2007-01-30 | Pfizer Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis |
US7094909B2 (en) | 2001-06-11 | 2006-08-22 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
EP1702916A1 (fr) * | 2005-03-18 | 2006-09-20 | Santhera Pharmaceuticals (Schweiz) GmbH | Inhibiteurs de DPP-IV |
GB0914574D0 (en) * | 2009-08-20 | 2009-09-30 | Givaudan Sa | Organic compounds |
KR102475443B1 (ko) | 2020-11-06 | 2022-12-08 | 함상덕 | 자동 필터 먼지제거장치 |
IL305835A (en) | 2021-03-15 | 2023-11-01 | Maze Therapeutics Inc | Glycogen synthase 1 (GYS1) inhibitors and methods of using them |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1182110A (fr) * | 1980-07-10 | 1985-02-05 | Hamao Umezawa | Tetrapeptides a action physiologique |
CA1340588C (fr) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Derive d'aminoacides |
-
1992
- 1992-02-07 IL IL100899A patent/IL100899A/xx not_active IP Right Cessation
- 1992-02-07 IE IE041492A patent/IE920414A1/en unknown
- 1992-02-07 ZA ZA92913A patent/ZA92913B/xx unknown
- 1992-02-07 CS CS92356A patent/CS35692A3/cs unknown
- 1992-02-07 HU HU9200392A patent/HUT60282A/hu unknown
- 1992-02-07 RU SU5011192A patent/RU2120447C1/ru active
- 1992-02-07 AU AU10812/92A patent/AU647239B2/en not_active Ceased
- 1992-02-07 CA CA002060844A patent/CA2060844A1/fr not_active Abandoned
- 1992-02-08 CN CN92101909A patent/CN1039321C/zh not_active Expired - Fee Related
- 1992-02-08 KR KR1019920001829A patent/KR920016417A/ko not_active Application Discontinuation
- 1992-02-08 TW TW081100868A patent/TW304197B/zh active
- 1992-02-10 EP EP92301100A patent/EP0498680A1/fr not_active Withdrawn
-
1995
- 1995-06-29 HU HU95P/P00606P patent/HU211834A9/hu unknown
Non-Patent Citations (1)
Title |
---|
1. ЕП заявка 0346847, кл. C 07 D 207/16, 1989. 2. ЕП заявка 0356223, кл. C 07 K 5/02, 1989. 3. ЕП заявка 337714, кл. C 07 K 5/02, 1989. 4. ЕП заявка 374098, кл. C 07 K 5/02, 1990. 5. ЕП заявка 386611, кл. C 07 K 5/02, 1990. * |
Also Published As
Publication number | Publication date |
---|---|
CN1039321C (zh) | 1998-07-29 |
HUT60282A (en) | 1992-08-28 |
CA2060844A1 (fr) | 1992-08-09 |
AU1081292A (en) | 1992-08-13 |
IL100899A (en) | 1997-06-10 |
EP0498680A1 (fr) | 1992-08-12 |
TW304197B (fr) | 1997-05-01 |
IL100899A0 (en) | 1992-11-15 |
ZA92913B (en) | 1993-05-06 |
CN1064683A (zh) | 1992-09-23 |
CS35692A3 (en) | 1992-09-16 |
IE920414A1 (en) | 1992-08-12 |
AU647239B2 (en) | 1994-03-17 |
HU9200392D0 (en) | 1992-04-28 |
KR920016417A (ko) | 1992-09-24 |
HU211834A9 (en) | 1995-12-28 |
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