RU2079506C1 - Пиразолопиримидинил- и пиримидинилалкилиденбисфосфоновые кислоты, их эфиры или фармацевтически приемлемые соли - Google Patents

Пиразолопиримидинил- и пиримидинилалкилиденбисфосфоновые кислоты, их эфиры или фармацевтически приемлемые соли Download PDF

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RU2079506C1
RU2079506C1 RU9293058618A RU93058618A RU2079506C1 RU 2079506 C1 RU2079506 C1 RU 2079506C1 RU 9293058618 A RU9293058618 A RU 9293058618A RU 93058618 A RU93058618 A RU 93058618A RU 2079506 C1 RU2079506 C1 RU 2079506C1
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Prior art keywords
propylidene
phenyl
bisphosphonic acid
methyl
pyrimidinyl
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RU9293058618A
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English (en)
Russian (ru)
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RU93058618A (ru
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Аллен Ньюджент Ричард
Томас Шлэхтер Стефен
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Дзе Апджон Компани
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU9293058618A 1991-07-03 1992-07-01 Пиразолопиримидинил- и пиримидинилалкилиденбисфосфоновые кислоты, их эфиры или фармацевтически приемлемые соли RU2079506C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72504791A 1991-07-03 1991-07-03
US72504691A 1991-07-03 1991-07-03
US07/725.046 1991-07-03
US07/725.047 1991-07-03
PCT/US1992/005398 WO1993001198A1 (en) 1991-07-03 1992-07-01 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories

Publications (2)

Publication Number Publication Date
RU93058618A RU93058618A (ru) 1996-12-27
RU2079506C1 true RU2079506C1 (ru) 1997-05-20

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RU9293058618A RU2079506C1 (ru) 1991-07-03 1992-07-01 Пиразолопиримидинил- и пиримидинилалкилиденбисфосфоновые кислоты, их эфиры или фармацевтически приемлемые соли

Country Status (19)

Country Link
US (1) US5397774A (https=)
EP (2) EP0521622B1 (https=)
JP (1) JPH06509100A (https=)
CN (1) CN1031826C (https=)
AT (1) ATE152728T1 (https=)
AU (1) AU653428B2 (https=)
CA (1) CA2110167A1 (https=)
CZ (1) CZ19595A3 (https=)
DE (1) DE69219602D1 (https=)
FI (1) FI935944A0 (https=)
HU (2) HUT70758A (https=)
IE (1) IE922162A1 (https=)
IL (1) IL102171A (https=)
MX (1) MX9203945A (https=)
NO (1) NO940009L (https=)
RU (1) RU2079506C1 (https=)
SK (1) SK277986B6 (https=)
TW (1) TW222638B (https=)
WO (1) WO1993001198A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид
RU2238932C2 (ru) * 1998-07-28 2004-10-27 Никокс С.А. Нитратные соли и фармацевтическая композиция на их основе

Families Citing this family (19)

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WO1994003463A1 (en) * 1992-08-07 1994-02-17 The Upjohn Company Phosphonoacetic esters and acids as anti-inflammatories
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories
WO1995011235A1 (en) * 1993-10-20 1995-04-27 The Upjohn Company Pyrimidinones as antiarthritic and anti-inflammatories
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6579860B1 (en) * 1998-12-25 2003-06-17 Toray Industries, Inc. Interleukin-6 production inhibitors
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
EP1926734A1 (en) 2005-08-22 2008-06-04 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
ES2650464T3 (es) * 2011-10-14 2018-01-18 Aktsionernoe Obshcestvo "Proizvodstvenno-Kommercheskaya Assotsiatsiya AZT" Sales de ésteres del ácido carbamoil-fosfónico que actúan como inhibidores selectivos de la producción del virus de la inmunodeficiencia humana VIH-1
WO2016031987A1 (ja) * 2014-08-29 2016-03-03 国立大学法人東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity

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US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ATE64397T1 (de) * 1986-11-21 1991-06-15 Ciba Geigy Ag Aromatisch substituierte azacycloalkylalkandiphosphons|uren.
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
AU4387893A (en) * 1992-07-16 1994-02-14 Upjohn Company, The Phosphono derivatives as antiinflammatory and antiarthritic agents
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories

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Заявка ФРГ N 2703712, кл. C 07 F 9/65, 1978. Европейский патент N 0274158, кл. C 07 F 9/65, 1988. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2238932C2 (ru) * 1998-07-28 2004-10-27 Никокс С.А. Нитратные соли и фармацевтическая композиция на их основе
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид

Also Published As

Publication number Publication date
FI935944L (fi) 1993-12-30
JPH06509100A (ja) 1994-10-13
SK277986B6 (en) 1995-09-13
AU2240892A (en) 1993-02-11
NO940009D0 (no) 1994-01-03
US5397774A (en) 1995-03-14
TW222638B (https=) 1994-04-21
EP0593575A1 (en) 1994-04-27
SK150493A3 (en) 1994-11-09
IL102171A0 (en) 1993-01-14
HUT70758A (en) 1995-10-30
CA2110167A1 (en) 1993-01-21
FI935944A7 (fi) 1993-12-30
NO940009L (no) 1994-01-09
EP0593575B1 (en) 1997-05-07
CZ19595A3 (en) 1995-10-18
ATE152728T1 (de) 1997-05-15
EP0521622A1 (en) 1993-01-07
HU211488A9 (en) 1995-11-28
MX9203945A (es) 1993-04-01
HU9400003D0 (en) 1994-05-30
DE69219602D1 (de) 1997-06-12
FI935944A0 (fi) 1993-12-30
EP0521622B1 (en) 1997-08-13
WO1993001198A1 (en) 1993-01-21
AU653428B2 (en) 1994-09-29
IL102171A (en) 1996-11-14
CN1068332A (zh) 1993-01-27
CN1031826C (zh) 1996-05-22
IE922162A1 (en) 1993-01-13

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