TW222638B - - Google Patents

Info

Publication number
TW222638B
TW222638B TW081104523A TW81104523A TW222638B TW 222638 B TW222638 B TW 222638B TW 081104523 A TW081104523 A TW 081104523A TW 81104523 A TW81104523 A TW 81104523A TW 222638 B TW222638 B TW 222638B
Authority
TW
Taiwan
Prior art keywords
compounds
useful
inflammation
inflammatory
chem
Prior art date
Application number
TW081104523A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of TW222638B publication Critical patent/TW222638B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
TW081104523A 1991-07-03 1992-06-10 TW222638B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72504791A 1991-07-03 1991-07-03
US72504691A 1991-07-03 1991-07-03

Publications (1)

Publication Number Publication Date
TW222638B true TW222638B (zh) 1994-04-21

Family

ID=27111084

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081104523A TW222638B (zh) 1991-07-03 1992-06-10

Country Status (19)

Country Link
US (1) US5397774A (zh)
EP (2) EP0521622B1 (zh)
JP (1) JPH06509100A (zh)
CN (1) CN1031826C (zh)
AT (1) ATE152728T1 (zh)
AU (1) AU653428B2 (zh)
CA (1) CA2110167A1 (zh)
CZ (1) CZ19595A3 (zh)
DE (1) DE69219602D1 (zh)
FI (1) FI935944A (zh)
HU (2) HUT70758A (zh)
IE (1) IE922162A1 (zh)
IL (1) IL102171A (zh)
MX (1) MX9203945A (zh)
NO (1) NO940009L (zh)
RU (1) RU2079506C1 (zh)
SK (1) SK277986B6 (zh)
TW (1) TW222638B (zh)
WO (1) WO1993001198A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654035B1 (en) * 1992-08-07 1997-08-20 PHARMACIA & UPJOHN COMPANY Phosphonoacetic esters and acids as anti-inflammatories
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
JPH09504010A (ja) * 1993-10-20 1997-04-22 ジ・アップジョン・カンパニー 抗関節炎剤および抗炎症剤としてのピリミジノン
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
EP1057488A4 (en) * 1998-12-25 2003-10-22 Toray Industries INTERLEUKIN-6 PRODUCTION INHIBITORS
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
AU2006283592A1 (en) 2005-08-22 2007-03-01 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
EP1884516A1 (en) * 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
CN104114570B (zh) * 2011-10-14 2016-08-31 齐多夫定生产和商业协会封闭式股份公司 作为人免疫缺陷病毒hiv-1产生的选择性抑制剂的氨基甲酰基膦酸酯盐
JP6632532B2 (ja) * 2014-08-29 2020-01-22 国立大学法人 東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3770787D1 (en) * 1986-11-21 1991-07-18 Ciba Geigy Ag Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
AU4387893A (en) * 1992-07-16 1994-02-14 Upjohn Company, The Phosphono derivatives as antiinflammatory and antiarthritic agents
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories

Also Published As

Publication number Publication date
JPH06509100A (ja) 1994-10-13
CZ19595A3 (en) 1995-10-18
HU211488A9 (en) 1995-11-28
CN1031826C (zh) 1996-05-22
AU2240892A (en) 1993-02-11
NO940009D0 (no) 1994-01-03
SK277986B6 (en) 1995-09-13
AU653428B2 (en) 1994-09-29
NO940009L (no) 1994-01-09
ATE152728T1 (de) 1997-05-15
MX9203945A (es) 1993-04-01
CN1068332A (zh) 1993-01-27
HUT70758A (en) 1995-10-30
RU2079506C1 (ru) 1997-05-20
FI935944A0 (fi) 1993-12-30
SK150493A3 (en) 1994-11-09
IE922162A1 (en) 1993-01-13
EP0521622B1 (en) 1997-08-13
US5397774A (en) 1995-03-14
EP0593575B1 (en) 1997-05-07
EP0521622A1 (en) 1993-01-07
DE69219602D1 (de) 1997-06-12
EP0593575A1 (en) 1994-04-27
WO1993001198A1 (en) 1993-01-21
HU9400003D0 (en) 1994-05-30
IL102171A (en) 1996-11-14
IL102171A0 (en) 1993-01-14
CA2110167A1 (en) 1993-01-21
FI935944A (fi) 1993-12-30

Similar Documents

Publication Publication Date Title
TW222638B (zh)
GR3026222T3 (en) Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
HK1009598A1 (en) 7-(Substituted)-9-(substituted glycyl)-amido)-6-demethyl-6-deoxytetracyclines
TW269678B (zh)
AP9600804A0 (en) Therapeutic amides.
KR930703355A (ko) 항생물질 ge2270 인자의 아미드
EP0604641A4 (en) COMPOSITION CONTAINING AMINO DERIVATIVES OR RELATED TO BENZOIC ACID AMINES AND USES THEREOF, INCLUDING IN THE TREATMENT OF INFLAMMATORY DISEASES.
MY111201A (en) New imidazopyridines
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
SE9100920D0 (sv) New active compounds
NZ322777A (en) Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents
ATE86960T1 (de) Cyclopropanderivate.
TW267161B (zh)
IT1271567B (it) Procedimento per l'ulteriore trattamento di salcicce
HU9400908D0 (en) Pharmaceutical compositions for treatng skin disorders
ATE153340T1 (de) Cyathane derivate und diese enthaltende nervenwachstumsfaktor produktion stimulatoren und antimikrobielle mittel
ES2068407T3 (es) Tratamiento de apneas durante el sueño con derivados de azapirona.
HK1067948A1 (en) Antitumor indolopyprolocarbazole derivative
AU4706489A (en) Oxadiazol-azabicycl compounds and their pharmaceutical use
FR2688819B1 (fr) Perfectionnements apportes aux dispositifs d'aeration des caveaux mortuaires.
TW226021B (zh)
AU6029090A (en) Improvements in or relating to organic compounds
CA2117330A1 (en) The use of psoralen compounds to inhibit restenosis following angioplasty
ITVI920177A1 (it) Impianto per l'odorizzazione del gas
ITMI930966A0 (it) Composizioni farmaceutiche per il trattamento della psoriasi