RU2020113627A - Композиции клеток, содержащие антигенспецифические т-клетки, для адоптивной терапии - Google Patents
Композиции клеток, содержащие антигенспецифические т-клетки, для адоптивной терапии Download PDFInfo
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- RU2020113627A RU2020113627A RU2020113627A RU2020113627A RU2020113627A RU 2020113627 A RU2020113627 A RU 2020113627A RU 2020113627 A RU2020113627 A RU 2020113627A RU 2020113627 A RU2020113627 A RU 2020113627A RU 2020113627 A RU2020113627 A RU 2020113627A
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4238—Regulators of development
- A61K40/424—Apoptosis related proteins, e.g. survivin or livin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4242—Transcription factors, e.g. SOX or c-MYC
- A61K40/4243—Wilms tumor 1 [WT1]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K40/427—PRAME
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
- A61K40/4272—Melan-A/MART
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A—HUMAN NECESSITIES
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- A61K2039/876—Skin, melanoma
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/2306—Interleukin-6 (IL-6)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/24—Interferons [IFN]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1114—T cells
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- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762561044P | 2017-09-20 | 2017-09-20 | |
| US62/561,044 | 2017-09-20 | ||
| US201862656679P | 2018-04-12 | 2018-04-12 | |
| US62/656,679 | 2018-04-12 | ||
| PCT/US2018/051971 WO2019060558A1 (en) | 2017-09-20 | 2018-09-20 | CELLULAR COMPOSITIONS COMPRISING ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE THERAPY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2020113627A true RU2020113627A (ru) | 2021-10-20 |
| RU2020113627A3 RU2020113627A3 (enExample) | 2021-11-30 |
Family
ID=65810886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020113627A RU2020113627A (ru) | 2017-09-20 | 2018-09-20 | Композиции клеток, содержащие антигенспецифические т-клетки, для адоптивной терапии |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20190119639A1 (enExample) |
| EP (1) | EP3684402A4 (enExample) |
| JP (1) | JP7475684B2 (enExample) |
| KR (1) | KR102850471B1 (enExample) |
| CN (1) | CN111629748A (enExample) |
| AU (1) | AU2018337960B2 (enExample) |
| BR (1) | BR112020005552A2 (enExample) |
| CA (1) | CA3076490A1 (enExample) |
| IL (1) | IL273452B2 (enExample) |
| MX (1) | MX2020003129A (enExample) |
| RU (1) | RU2020113627A (enExample) |
| SG (1) | SG11202002523YA (enExample) |
| WO (1) | WO2019060558A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1814580T3 (en) | 2004-11-24 | 2016-12-12 | Hutchinson Fred Cancer Res | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| CN120519386A (zh) | 2017-11-08 | 2025-08-22 | 百欧恩泰美国公司 | T细胞制备组合物和方法 |
| US20220016166A1 (en) * | 2018-09-21 | 2022-01-20 | Cafa Therapeutics Limited | T-cell expressing chimeric receptor |
| US20200188435A1 (en) * | 2018-11-08 | 2020-06-18 | Nexlmmune, Inc. | T cell compositions with improved phenotypic properties |
| TWI867324B (zh) * | 2019-05-08 | 2024-12-21 | 美商百歐恩泰美國公司 | T細胞製備組合物及方法 |
| BR112022021551A2 (pt) | 2020-04-28 | 2023-01-03 | Lyell Immunopharma Inc | Métodos para cultivar células |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| WO2022234856A1 (ja) * | 2021-05-07 | 2022-11-10 | 康人 徳元 | メモリーt細胞の製造方法 |
| CN113945715B (zh) * | 2021-08-30 | 2023-04-21 | 四川大学华西医院 | 供者特异性IL-21和IFN-γ的检测方法及应用 |
| EP4463542A1 (en) * | 2022-02-15 | 2024-11-20 | Marker Therapeutics, Inc. | Compositions and methods for antigen-specific t cell expansion |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
| US20050169898A1 (en) * | 1997-04-15 | 2005-08-04 | Jianlin Gong | Cell fusions and methods of making and using the same |
| KR102073901B1 (ko) * | 2011-09-08 | 2020-02-05 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 항 제3자 중심 기억 t 세포, 이의 제조 방법, 및 이식 및 질환 치료에서의 이의 용도 |
| WO2014039044A1 (en) * | 2012-09-06 | 2014-03-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t memory stem cell populations |
| WO2014209868A1 (en) | 2013-06-24 | 2014-12-31 | Neximmune | Compositions and methods for immunotherapy |
| CA2961749C (en) * | 2014-09-17 | 2021-01-12 | The Johns Hopkins University | Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells |
| EP3034092A1 (en) * | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| MX391015B (es) | 2014-12-24 | 2025-03-21 | Neximmune Inc | Composiciones de nanoparticulas y usos de las mismas |
| MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
| TW201621210A (zh) * | 2016-02-26 | 2016-06-16 | Liquidleds Lighting Corp | 發光二極體光源及燈具 |
| AU2017233035B2 (en) * | 2016-03-16 | 2021-08-05 | Neximmune, Inc. | Production of antigen-specific T-cells |
-
2018
- 2018-09-20 CN CN201880074419.8A patent/CN111629748A/zh active Pending
- 2018-09-20 RU RU2020113627A patent/RU2020113627A/ru unknown
- 2018-09-20 EP EP18859009.5A patent/EP3684402A4/en active Pending
- 2018-09-20 CA CA3076490A patent/CA3076490A1/en active Pending
- 2018-09-20 KR KR1020207011215A patent/KR102850471B1/ko active Active
- 2018-09-20 JP JP2020516552A patent/JP7475684B2/ja active Active
- 2018-09-20 BR BR112020005552-2A patent/BR112020005552A2/pt unknown
- 2018-09-20 IL IL273452A patent/IL273452B2/en unknown
- 2018-09-20 US US16/136,931 patent/US20190119639A1/en not_active Abandoned
- 2018-09-20 MX MX2020003129A patent/MX2020003129A/es unknown
- 2018-09-20 WO PCT/US2018/051971 patent/WO2019060558A1/en not_active Ceased
- 2018-09-20 AU AU2018337960A patent/AU2018337960B2/en active Active
- 2018-09-20 SG SG11202002523YA patent/SG11202002523YA/en unknown
-
2022
- 2022-11-18 US US17/989,905 patent/US20230399613A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019060558A1 (en) | 2019-03-28 |
| IL273452A (en) | 2020-05-31 |
| BR112020005552A2 (pt) | 2020-10-27 |
| JP7475684B2 (ja) | 2024-04-30 |
| AU2018337960B2 (en) | 2025-08-14 |
| RU2020113627A3 (enExample) | 2021-11-30 |
| EP3684402A1 (en) | 2020-07-29 |
| CN111629748A (zh) | 2020-09-04 |
| AU2018337960A1 (en) | 2020-04-30 |
| IL273452B2 (en) | 2025-02-01 |
| US20230399613A1 (en) | 2023-12-14 |
| KR102850471B1 (ko) | 2025-08-27 |
| CA3076490A1 (en) | 2019-03-28 |
| KR20200104283A (ko) | 2020-09-03 |
| SG11202002523YA (en) | 2020-04-29 |
| EP3684402A4 (en) | 2021-05-26 |
| JP2020534313A (ja) | 2020-11-26 |
| IL273452B1 (en) | 2024-10-01 |
| US20190119639A1 (en) | 2019-04-25 |
| MX2020003129A (es) | 2020-10-12 |
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