KR102850471B1 - 입양 요법을 위한 항원-특이적 t 세포를 포함하는 세포 조성물 - Google Patents

입양 요법을 위한 항원-특이적 t 세포를 포함하는 세포 조성물

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KR102850471B1
KR102850471B1 KR1020207011215A KR20207011215A KR102850471B1 KR 102850471 B1 KR102850471 B1 KR 102850471B1 KR 1020207011215 A KR1020207011215 A KR 1020207011215A KR 20207011215 A KR20207011215 A KR 20207011215A KR 102850471 B1 KR102850471 B1 KR 102850471B1
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cells
delete delete
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antigen
cell
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KR20200104283A (ko
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마티아스 을케
크리스티 존스
소정 김
로렌 수아레즈
켄 카터
스콧 카메르
댄 베드나릭
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넥스이뮨, 인크.
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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KR1020207011215A 2017-09-20 2018-09-20 입양 요법을 위한 항원-특이적 t 세포를 포함하는 세포 조성물 Active KR102850471B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762561044P 2017-09-20 2017-09-20
US62/561,044 2017-09-20
US201862656679P 2018-04-12 2018-04-12
US62/656,679 2018-04-12
PCT/US2018/051971 WO2019060558A1 (en) 2017-09-20 2018-09-20 CELLULAR COMPOSITIONS COMPRISING ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE THERAPY

Publications (2)

Publication Number Publication Date
KR20200104283A KR20200104283A (ko) 2020-09-03
KR102850471B1 true KR102850471B1 (ko) 2025-08-27

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US (2) US20190119639A1 (enExample)
EP (1) EP3684402A4 (enExample)
JP (1) JP7475684B2 (enExample)
KR (1) KR102850471B1 (enExample)
CN (1) CN111629748A (enExample)
AU (1) AU2018337960B2 (enExample)
BR (1) BR112020005552A2 (enExample)
CA (1) CA3076490A1 (enExample)
IL (1) IL273452B2 (enExample)
MX (1) MX2020003129A (enExample)
RU (1) RU2020113627A (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1814580T3 (en) 2004-11-24 2016-12-12 Hutchinson Fred Cancer Res Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
CN120519386A (zh) 2017-11-08 2025-08-22 百欧恩泰美国公司 T细胞制备组合物和方法
US20220016166A1 (en) * 2018-09-21 2022-01-20 Cafa Therapeutics Limited T-cell expressing chimeric receptor
US20200188435A1 (en) * 2018-11-08 2020-06-18 Nexlmmune, Inc. T cell compositions with improved phenotypic properties
TWI867324B (zh) * 2019-05-08 2024-12-21 美商百歐恩泰美國公司 T細胞製備組合物及方法
BR112022021551A2 (pt) 2020-04-28 2023-01-03 Lyell Immunopharma Inc Métodos para cultivar células
BR112023022765A2 (pt) 2021-05-05 2024-01-02 Immatics Biotechnologies Gmbh Proteínas de ligação ao antígeno que ligam especificamente o prame
WO2022234856A1 (ja) * 2021-05-07 2022-11-10 康人 徳元 メモリーt細胞の製造方法
CN113945715B (zh) * 2021-08-30 2023-04-21 四川大学华西医院 供者特异性IL-21和IFN-γ的检测方法及应用
EP4463542A1 (en) * 2022-02-15 2024-11-20 Marker Therapeutics, Inc. Compositions and methods for antigen-specific t cell expansion

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170246277A1 (en) * 2014-09-17 2017-08-31 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US20050169898A1 (en) * 1997-04-15 2005-08-04 Jianlin Gong Cell fusions and methods of making and using the same
KR102073901B1 (ko) * 2011-09-08 2020-02-05 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 항 제3자 중심 기억 t 세포, 이의 제조 방법, 및 이식 및 질환 치료에서의 이의 용도
WO2014039044A1 (en) * 2012-09-06 2014-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t memory stem cell populations
WO2014209868A1 (en) 2013-06-24 2014-12-31 Neximmune Compositions and methods for immunotherapy
EP3034092A1 (en) * 2014-12-17 2016-06-22 Université de Lausanne Adoptive immunotherapy for treating cancer
MX391015B (es) 2014-12-24 2025-03-21 Neximmune Inc Composiciones de nanoparticulas y usos de las mismas
MA44314A (fr) 2015-11-05 2018-09-12 Juno Therapeutics Inc Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées
TW201621210A (zh) * 2016-02-26 2016-06-16 Liquidleds Lighting Corp 發光二極體光源及燈具
AU2017233035B2 (en) * 2016-03-16 2021-08-05 Neximmune, Inc. Production of antigen-specific T-cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170246277A1 (en) * 2014-09-17 2017-08-31 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

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AU2018337960B2 (en) 2025-08-14
RU2020113627A3 (enExample) 2021-11-30
EP3684402A1 (en) 2020-07-29
CN111629748A (zh) 2020-09-04
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AU2018337960A1 (en) 2020-04-30
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US20230399613A1 (en) 2023-12-14
CA3076490A1 (en) 2019-03-28
KR20200104283A (ko) 2020-09-03
SG11202002523YA (en) 2020-04-29
EP3684402A4 (en) 2021-05-26
JP2020534313A (ja) 2020-11-26
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US20190119639A1 (en) 2019-04-25
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