RU2019129727A - Применения пиримидопиримидинонов в качестве ингибиторов sik - Google Patents

Применения пиримидопиримидинонов в качестве ингибиторов sik Download PDF

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Publication number
RU2019129727A
RU2019129727A RU2019129727A RU2019129727A RU2019129727A RU 2019129727 A RU2019129727 A RU 2019129727A RU 2019129727 A RU2019129727 A RU 2019129727A RU 2019129727 A RU2019129727 A RU 2019129727A RU 2019129727 A RU2019129727 A RU 2019129727A
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substituted
unsubstituted
alkyl
protecting group
hydrogen
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RU2019129727A
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RU2019129727A3 (cg-RX-API-DMAC10.html
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Дэвид Е. ФИШЕР
Нисма МУДЖАХИД
Натаниэль С. ГРЭЙ
Янке ЛИАНГ
Рё МУРАКАМИ
Хван Геун ЧОЙ
Original Assignee
Зэ Дженерал Хоспитал Корпорэйшн
Дана-Фарбер Кэнсер Инститьют, Инк.
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Publication of RU2019129727A publication Critical patent/RU2019129727A/ru
Publication of RU2019129727A3 publication Critical patent/RU2019129727A3/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2019129727A 2017-02-28 2018-02-28 Применения пиримидопиримидинонов в качестве ингибиторов sik RU2019129727A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762464675P 2017-02-28 2017-02-28
US62/464,675 2017-02-28
US201762472468P 2017-03-16 2017-03-16
US62/472,468 2017-03-16
PCT/US2018/020335 WO2018160774A1 (en) 2017-02-28 2018-02-28 Uses of pyrimidopyrimidinones as sik inhibitors

Publications (2)

Publication Number Publication Date
RU2019129727A true RU2019129727A (ru) 2021-03-30
RU2019129727A3 RU2019129727A3 (cg-RX-API-DMAC10.html) 2021-07-02

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RU2019129727A RU2019129727A (ru) 2017-02-28 2018-02-28 Применения пиримидопиримидинонов в качестве ингибиторов sik

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Country Link
US (3) US11285158B2 (cg-RX-API-DMAC10.html)
EP (1) EP3589284A4 (cg-RX-API-DMAC10.html)
JP (2) JP7296318B2 (cg-RX-API-DMAC10.html)
KR (1) KR20190120331A (cg-RX-API-DMAC10.html)
CN (1) CN111163771B (cg-RX-API-DMAC10.html)
AU (1) AU2018226771B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019017741A2 (cg-RX-API-DMAC10.html)
CA (1) CA3054809A1 (cg-RX-API-DMAC10.html)
RU (1) RU2019129727A (cg-RX-API-DMAC10.html)
WO (1) WO2018160774A1 (cg-RX-API-DMAC10.html)

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Also Published As

Publication number Publication date
EP3589284A4 (en) 2020-12-16
US20200253981A1 (en) 2020-08-13
JP7296318B2 (ja) 2023-06-22
CN111163771B (zh) 2023-07-14
AU2018226771A1 (en) 2019-09-19
CN111163771A (zh) 2020-05-15
BR112019017741A2 (pt) 2020-04-07
US20240245695A1 (en) 2024-07-25
CA3054809A1 (en) 2018-09-07
US11285158B2 (en) 2022-03-29
JP2023088968A (ja) 2023-06-27
US11878019B2 (en) 2024-01-23
WO2018160774A1 (en) 2018-09-07
AU2018226771B2 (en) 2023-11-23
US20220133736A1 (en) 2022-05-05
EP3589284A1 (en) 2020-01-08
RU2019129727A3 (cg-RX-API-DMAC10.html) 2021-07-02
JP2020509022A (ja) 2020-03-26
KR20190120331A (ko) 2019-10-23

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