RU2019113140A - Материал для предотвращения появления спаек - Google Patents

Материал для предотвращения появления спаек Download PDF

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RU2019113140A
RU2019113140A RU2019113140A RU2019113140A RU2019113140A RU 2019113140 A RU2019113140 A RU 2019113140A RU 2019113140 A RU2019113140 A RU 2019113140A RU 2019113140 A RU2019113140 A RU 2019113140A RU 2019113140 A RU2019113140 A RU 2019113140A
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integer
preventing
acid
appearance
formula
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RU2019113140A
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Акихиро САИТО
Мегуми НАКАНИСИ
Кадзухиро ТАНАХАСИ
Тору АРАКАНЕ
Мотонори ХОТИ
Аи СУЗУКИ
Кодзи ОКАБАЯСИ
Синдзи ТАКЕОКА
Тосинори ФУДЗИЕ
Юя ИСИДУКА
Синия ОЦУБО
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Торэй Индастриз, Инк.
Нанотета Ко., Лтд.
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
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    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
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    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
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    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C08L71/10—Polyethers derived from hydroxy compounds or from their metallic derivatives from phenols
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A—HUMAN NECESSITIES
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Claims (21)

1. Материал для предотвращения появления спаек, состоящий из водорастворимого слоя основы толщиной 1-1000 мкм, содержащего водорастворимый полимер, и слоя предотвращения появления спаек толщиной 10-1000 нм, содержащего биодеградируемый полимер, где биодеградируемый полимер состоит из разветвленного полиалкиленгликоля, содержащего 3-8 концевых гидроксильных групп на молекулу, связанного с полигидроксиалкановой кислотой, и массовое отношение разветвленного полиалкиленгликоля по отношению к общей массе составляет 1% - 40%.
2. Материал для предотвращения появления спаек по п.1, где разветвленный полиалкиленгликоль состоит из линейного полиалкиленгликоля, связанного с многоатомным спиртом.
3. Материал для предотвращения появления спаек по п.1 или 2, где полигидроксиалкановая кислота представляет собой гомополимер из мономеров, выбранных из группы, состоящей из молочной кислоты, гликолевой кислоты и капроновой кислоты или сополимера двух или более мономеров.
4. Материал для предотвращения появления спаек по любому из пп.1-3, где биодеградируемый полимер имеет структуру, представленную Формулой (I):
Figure 00000001
,
где l, m, n и o, каждый, независимо представляют собой целое число от 24 до 88 и A, B, C и D, каждый, независимо представляют собой группу, представленную Формулой (II):
Figure 00000002
где x представляет собой целое число от 90 до 148 или группу, представленную Формулой (III):
Figure 00000003
где y представляет собой целое число от 72 до 132 и z представляет собой целое число от 19 до 39.
5. Материал для предотвращения появления спаек по любому из пп.1-4, где биодеградируемый полимер имеет структуру, представленную Формулой (IV):
Figure 00000004
где p, q, r, s и t каждый, независимо представляют собой в каждой повторяющейся единице целое число от 5 до 20, u представляет собой целое число от 0 до 4, и A, B, C, D и E каждый, независимо, в каждой повторяющейся единице, представляют собой группу, представленную Формулой (II):
Figure 00000002
где x представляет собой целое число от 40 до 80 или группу, представленную Формулой (III):
Figure 00000003
где y представляет собой целое число от 35 до 65 и z представляет собой целое число от 9 до 20.
6. Материал для предотвращения появления спаек по любому из пп.1-5, где полигидроксиалкановая кислота в биодеградируемом полимере, представленном Формулами (I) и (IV), представляет собой сополимер молочной кислоты и гликолевой кислоты, и отношение количества молей молочной кислоты относительно количества молей гликолевой кислоты в биодеградируемом полимере составляет 3,0-5,0.
7. Материал для предотвращения появления спаек по любому из пп.1-6, где водорастворимый полимер представляет собой полисахарид или модифицированный полисахарид.
8. Материал для предотвращения появления спаек по любому из пп.1-6, где водорастворимый полимер выбирается из группы, состоящей из пуллулана, гиалуроновой кислоты, ацилированного пуллулана, ацилированной гиалуроновой кислоты, ацетилированного пуллулана, ацетилированной гиалуроновой кислоты и смеси двух или более из них.
9. Материал для предотвращения появления спаек по любому из пп.1-8, где на подложке создается слой основы, слой основы приклеивается к подложке с такой прочностью, что его можно отслоить с подложки, и слой предотвращения появления спаек создается на слое основы.
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CA3038959A1 (en) 2018-04-05
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JPWO2018062464A1 (ja) 2019-07-11
CN109715222A (zh) 2019-05-03
KR102448320B1 (ko) 2022-09-30
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