RU2019101223A - Сополимер и разделительная мембрана, устройство медицинского назначения и устройство для очистки крови, в котором используют этот сополимер - Google Patents

Сополимер и разделительная мембрана, устройство медицинского назначения и устройство для очистки крови, в котором используют этот сополимер Download PDF

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RU2019101223A
RU2019101223A RU2019101223A RU2019101223A RU2019101223A RU 2019101223 A RU2019101223 A RU 2019101223A RU 2019101223 A RU2019101223 A RU 2019101223A RU 2019101223 A RU2019101223 A RU 2019101223A RU 2019101223 A RU2019101223 A RU 2019101223A
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monomer unit
energy
copolymer
hydration
specific
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RU2019101223A
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RU2019101223A3 (ru
RU2735601C2 (ru
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Такеси БАБА
Томонори КАВАКАМИ
Сугуру УСИРО
Йосиюки УЕНО
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Торэй Индастриз, Инк.
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Claims (32)

1. Сополимер, включающий два или более типов мономерных звеньев,
где
два или более типов мономерных звеньев включают гидрофобное мономерное звено и гидрофильное мономерное звено,
гидрофобное мономерное звено представляет собой повторяющееся звено в гомополимере или сополимере, полученном полимеризацией мономеров, выбранных из группы, состоящей из винилкарбоксилата, метакрилата, акрилата и производного стирола, и
гидрофильное мономерное звено представляет собой повторяющееся звено в гомополимере или сополимере, полученном полимеризацией мономеров, выбранных из группы, состоящей из N-виниламида, производного акриламида, производного метакриламида, N-виниллактама и N-акрилоилморфолина,
среднечисловая молекулярная масса сополимера составляет 2000 или более и 1000000 или менее
удельная энергия гидратации сополимера, рассчитанная на основе следующей формулы (1) составляет от 158,992 до 209,200 кДж⋅моль-1⋅нм-3,
мономерное звено с самой высокой удельной энергией гидратации мономерного звена i, рассчитанной на основе следующей формулы (2), представляет собой мономерное звено, не содержащее гидроксильную группу,
объемная доля мономерного звена с самой высокой удельной энергией гидратации мономерного звена i, рассчитанной на основе следующей формулы (3), составляет от 35 до 90%,
разница в удельной энергии гидратации, рассчитанная по следующей формуле (4), составляет от 71,128 до 418,400 кДж⋅моль-1⋅нм-3,
Удельная энергия гидратации (кал·моль-1·Å-3) сополимера =
Figure 00000001
{(мольная доля мономерного звена i) x (энергия гидратации мономерного звена i)}/
Figure 00000002
{(мольная доля мономерного звена i) x (объем мономерного звена i)} - формула (1),
где энергия гидратации мономерного звена i представляет собой абсолютное значение величины, полученной путем вычитания энергии мономерного звена i в вакууме из энергии мономерного звена i в воде, N представляет суммарное число видов мономеров, которые образуют сополимер, и i представляет целое число от 1 или более и до N или менее,
Удельная энергия гидратации (кал·моль-1·Å-3) мономерное звено i=(энергия гидратации мономерного звена i)/(объем мономерного звена i) - формула (2),
Объемная доля (%) мономерного звена с самой высокой удельной энергией гидратации мономерного звена i =
мольная доля мономерного звена с самой высокой удельной энергией гидратации мономерного звена i x
объем мономерного звена с самой высокой удельной энергией гидратации мономерного звена i/
Figure 00000003
{(мольная доля мономерного звена i) х (объем мономерного звена i)} - формула (3),
где N и i определенны выше, и
Разница в удельной энергии гидратации (кал·моль-1·Å-3) =
(удельная энергия гидратации мономерного звена с самой высокой удельной энергией гидратации мономерного звена) - (удельная энергия гидратации мономерного звена с самой низкой удельной энергией гидратации мономерного звена) - формула (4).
2. Сополимер по п. 1, где
удельная энергия гидратации сополимера составляет от 167,360 до 200,832 кДж⋅моль-1⋅нм-3,
объемная доля мономерного звена с самой высокой удельной энергией гидратации мономерного звена i составляет от 40 до 80%, и
разница в удельной энергии гидратации составляет от 71,128 до 313,800 кДж⋅моль-1⋅нм-3.
3. Сополимер по п. 1 или 2, где
гидрофобное мономерное звено представляет собой повторяющееся звено в гомополимере, полученном полимеризацией винилкарбоксилата, или в сополимере, полученном сополимеризацией винилкарбоксилата, и
гидрофильное мономерное звено представляет собой повторяющееся звено в гомополимере, полученном полимеризацией N-виниллактама, или в сополимере, полученном сополимеризацией N-виниллактама.
4. Разделительная мембрана, включающая сополимер по любому одному из пп. 1-3.
5. Устройство медицинского назначения, включающее сополимер по любому одному из пп. 1-3.
6. Устройство для очистки крови, включающее разделительную мембрану по п. 4.
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