RU2018145734A - Химические соединения в качестве ингибиторов atf4 пути - Google Patents

Химические соединения в качестве ингибиторов atf4 пути Download PDF

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RU2018145734A
RU2018145734A RU2018145734A RU2018145734A RU2018145734A RU 2018145734 A RU2018145734 A RU 2018145734A RU 2018145734 A RU2018145734 A RU 2018145734A RU 2018145734 A RU2018145734 A RU 2018145734A RU 2018145734 A RU2018145734 A RU 2018145734A
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chlorophenoxy
cancer
acetamide
piperidin
disease
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RU2018145734A
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Russian (ru)
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Джеффри ЭКСТЕН
Муи Чеунг
Майкл П. Демартино
Хилари Шенк Эйдам
Рагхава Редди КЕТХИРИ
Бисваджит КАЛИТА
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Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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Publication of RU2018145734A publication Critical patent/RU2018145734A/ru

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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