RU2018140275A - Однодозовый фармацевтический препарат тиреоидных гормонов t3 и/или t4 - Google Patents
Однодозовый фармацевтический препарат тиреоидных гормонов t3 и/или t4 Download PDFInfo
- Publication number
- RU2018140275A RU2018140275A RU2018140275A RU2018140275A RU2018140275A RU 2018140275 A RU2018140275 A RU 2018140275A RU 2018140275 A RU2018140275 A RU 2018140275A RU 2018140275 A RU2018140275 A RU 2018140275A RU 2018140275 A RU2018140275 A RU 2018140275A
- Authority
- RU
- Russia
- Prior art keywords
- polyethylene
- container
- hormone
- pharmaceutical preparation
- resins
- Prior art date
Links
- 239000005495 thyroid hormone Substances 0.000 title claims 5
- 229940036555 thyroid hormone Drugs 0.000 title claims 5
- 229940079593 drug Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- -1 polyethylene Polymers 0.000 claims 7
- 239000004698 Polyethylene Substances 0.000 claims 5
- 229920000573 polyethylene Polymers 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 229910052782 aluminium Inorganic materials 0.000 claims 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 3
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920003023 plastic Polymers 0.000 claims 3
- 239000004033 plastic Substances 0.000 claims 3
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- 229920006026 co-polymeric resin Polymers 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 235000019441 ethanol Nutrition 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229920000554 ionomer Polymers 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 1
- 239000004713 Cyclic olefin copolymer Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920001684 low density polyethylene Polymers 0.000 claims 1
- 239000004702 low-density polyethylene Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000005033 polyvinylidene chloride Substances 0.000 claims 1
- MXNUCYGENRZCBO-UHFFFAOYSA-M sodium;ethene;2-methylprop-2-enoate Chemical class [Na+].C=C.CC(=C)C([O-])=O MXNUCYGENRZCBO-UHFFFAOYSA-M 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (10)
1. Однодозовый фармацевтический препарат тиреоидных гормонов T3 и T4, подходящий для перорального введения, в готовой к применению упаковке, состоящей из ёмкости, предварительно заполненной водно-спиртовым раствором гормона T3 и/или T4, причём указанная ёмкость выбрана из:
(a) однокомпонентной пластмассовой ёмкости из полиэтилена низкого давления (ПЭНП), поддающейся сжатию рукой и имеющей модуль Юнга от 10 до 200 МПа, помещённой в запечатанный пакет-саше, состоящий из многослойной плёнки, изготовленной из материалов, выбранных из: полиэтилена, алюминия, полиэтилентерефталата, иономерных смол, сополимерных смол этилена и винилового спирта, полипропилена и фторированных-хлорированных смол;
(b) многокомпонентной ёмкости из многослойной пластмассы, имеющей толщину от 200 до 700 мкм, поддающейся сжатию рукой и имеющей модуль Юнга от 10 до 200 МПа, причём указанная ёмкость состоит из множества слоёв пластиковых материалов, выбранных из полиэтилена, сополимерных смол этилена и винилового спирта, поливинилхлорида, поливинилиденхлорида, поливинилацетата, фторированных-хлорированных смол, иономерных смол, циклических олефиновых сополимеров, полиамида, полистирола, поликарбоната и плакированных металлов.
2. Фармацевтический препарат по п. 1, отличающий тем, что указанный пакет-саше состоит из многослойной плёнки, изготовленной из различных материалов в следующих комбинациях: полиэтилен, алюминий и полиэфир; полиэтилен, алюминий и бумага; иономерные смолы, алюминий и бумага.
3. Фармацевтический препарат по пп. 1 и 2, отличающийся тем, что указанный пакет-саше проявляет проницаемость в отношении кислорода и водяного пара, находящуюся в диапазоне от 0,1 до 0,2 см3/м2/сутки.
4. Фармацевтический препарат по пп. 1-3, отличающийся тем, что водно-спиртовой раствор содержит от 1 до 20 мкг тиреоидного гормона T3 и/или от 12,5 до 200 мкг тиреоидного гормона T4.
5. Фармацевтический препарат по п. 4, отличающийся тем, что указанный водно-спиртовой раствор также содержит этиловый спирт, глицерин и воду.
6. Фармацевтический препарат по п. 5, отличающийся тем, что указанный водно-спиртовой раствор содержит от 5 до 30% масс./об. этилового спирта и от 70 до 95% масс./об. глицерина.
7. Фармацевтический препарат по пп. 1-6 для применения для лечения заболеваний, связанных с дефицитом гормона T3 и/или T4.
8. Применение водно-спиртового раствора тиреоидного гормона T3 и/или T4 в ёмкости по пп. 1-6 для получения лекарственного средства для перорального введения для применения в лечении заболеваний, связанных с дефицитом гормона T3 и/или T4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002066A ITMI20112066A1 (it) | 2011-11-14 | 2011-11-14 | Preparazione farmaceutica orale monodose di ormoni tiroidei t3 e t4 |
| ITMI2011A002066 | 2011-11-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014119151A Division RU2688430C2 (ru) | 2011-11-14 | 2012-11-13 | Однодозовый фармацевтический препарат тиреоидных гормонов т3 и/или т4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018140275A true RU2018140275A (ru) | 2019-01-18 |
| RU2018140275A3 RU2018140275A3 (ru) | 2022-03-23 |
Family
ID=45315902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018140275A RU2018140275A (ru) | 2011-11-14 | 2012-11-13 | Однодозовый фармацевтический препарат тиреоидных гормонов t3 и/или t4 |
| RU2014119151A RU2688430C2 (ru) | 2011-11-14 | 2012-11-13 | Однодозовый фармацевтический препарат тиреоидных гормонов т3 и/или т4 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014119151A RU2688430C2 (ru) | 2011-11-14 | 2012-11-13 | Однодозовый фармацевтический препарат тиреоидных гормонов т3 и/или т4 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140179785A1 (ru) |
| EP (2) | EP2790638B1 (ru) |
| CN (2) | CN103987358B (ru) |
| CA (1) | CA2853880C (ru) |
| DK (2) | DK2790638T3 (ru) |
| ES (2) | ES2621009T3 (ru) |
| FI (1) | FI3056187T4 (ru) |
| HK (1) | HK1200692A1 (ru) |
| HU (1) | HUE033305T2 (ru) |
| IT (1) | ITMI20112066A1 (ru) |
| PL (2) | PL2790638T3 (ru) |
| PT (2) | PT2790638T (ru) |
| RU (2) | RU2018140275A (ru) |
| WO (1) | WO2013072304A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013017917A1 (de) * | 2013-10-26 | 2015-04-30 | Michael Raschke | L-Thyrogal |
| EP3311844A1 (en) | 2016-10-18 | 2018-04-25 | Altergon S.A. | High-stability packaged solutions of t4 thyroid hormone |
| US11241382B2 (en) | 2019-03-01 | 2022-02-08 | Altergon Sa | Administration regimen of compositions of T4 thyroid hormone with high oral absorption |
| IT201900003013A1 (it) | 2019-03-01 | 2020-09-01 | Altergon Sa | Regime di somministrazione di composizioni di ormone tiroideo T4 con elevato assorbimento orale |
| WO2022221480A1 (en) * | 2021-04-15 | 2022-10-20 | Vertice Pharma Llc | Stable liquid oral dosage forms of liothyronine |
| IT202100020105A1 (it) | 2021-07-28 | 2023-01-28 | Altergon Sa | Utilizzo di ormone tiroideo T4 in un trattamento ad elevata versatilità in pazienti che assumono inibitori della pompa protonica |
| EP4295836A1 (en) * | 2022-06-22 | 2023-12-27 | Labomed Pharmaceutical Company S.A. | Sachet comprising a liquid suspension of a sevelamer salt |
| CN115645361B (zh) * | 2022-09-30 | 2023-11-21 | 天津市眼科医院 | 一种用于加强角膜生物力学性质的眼用制剂及t3的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3128920A (en) * | 1964-04-14 | figure | ||
| SE9602352D0 (sv) * | 1996-06-14 | 1996-06-14 | Astra Ab | Catheter package |
| UA80393C2 (ru) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтическая композиция, которая содержит ингибитор фдэ 4, диспергированный в матрице |
| ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
| GB0316206D0 (en) * | 2003-07-10 | 2003-08-13 | Glaxo Group Ltd | Pharmaceutical formulation |
| WO2006053297A1 (en) * | 2004-11-08 | 2006-05-18 | E.I. Dupont De Nemours And Company | Toughened polyamide for food packaging and health care applications |
| BRPI0519561A2 (pt) | 2004-12-27 | 2009-01-27 | King Pharmaceuticals Res & Dev | composiÇço farmacÊutica de hormânio da tireàide, embalagem farmacÊutica, e, mÉtodo de acondicionamento de uma composiÇço farmacÊutica de hormânio da tireàide |
| CN1820782B (zh) * | 2005-02-17 | 2012-08-29 | 阿尔特贡股份公司 | 甲状腺激素药物制剂及其制备方法 |
| AU2006230557A1 (en) * | 2005-03-31 | 2006-10-05 | King Pharmaceuticals Research & Development, Inc. | Controlled release pharmaceutical compositions of liothyronine and methods of making and using the same |
| BRPI0710416A2 (pt) * | 2006-05-01 | 2011-08-09 | Nanopack Inc | pelìcula revestida, composição, corpo moldado revestido, método para preparar uma composição de pelìcula revestida e método para estabilizar uma suspensão |
| WO2009082132A2 (en) * | 2007-12-24 | 2009-07-02 | Choongwae Corporation | Multilayer film for medical solution container and a container comprising the same |
| DE102008056123B4 (de) * | 2008-11-06 | 2017-11-16 | Klöckner Pentaplast Gmbh | Mehrschichtfolie und Blisterverpackung |
| IT1393524B1 (it) * | 2009-01-30 | 2012-04-27 | Altergon Sa | Contenitore per uso farmaceutico atto al rilascio quantitativo di una monodose per somministrazione orale di ormoni tiroidei t3 e t4 in soluzione |
-
2011
- 2011-11-14 IT IT002066A patent/ITMI20112066A1/it unknown
-
2012
- 2012-11-13 CA CA2853880A patent/CA2853880C/en active Active
- 2012-11-13 FI FIEP16154717.9T patent/FI3056187T4/fi active
- 2012-11-13 DK DK12798182.7T patent/DK2790638T3/en active
- 2012-11-13 ES ES12798182.7T patent/ES2621009T3/es active Active
- 2012-11-13 US US13/814,770 patent/US20140179785A1/en not_active Abandoned
- 2012-11-13 CN CN201280055960.7A patent/CN103987358B/zh active Active
- 2012-11-13 PL PL12798182T patent/PL2790638T3/pl unknown
- 2012-11-13 EP EP12798182.7A patent/EP2790638B1/en active Active
- 2012-11-13 RU RU2018140275A patent/RU2018140275A/ru unknown
- 2012-11-13 HU HUE12798182A patent/HUE033305T2/en unknown
- 2012-11-13 DK DK16154717.9T patent/DK3056187T4/da active
- 2012-11-13 CN CN201710217112.6A patent/CN107049929B/zh active Active
- 2012-11-13 PL PL16154717.9T patent/PL3056187T5/pl unknown
- 2012-11-13 RU RU2014119151A patent/RU2688430C2/ru active
- 2012-11-13 WO PCT/EP2012/072482 patent/WO2013072304A1/en active Application Filing
- 2012-11-13 PT PT127981827T patent/PT2790638T/pt unknown
- 2012-11-13 PT PT16154717T patent/PT3056187T/pt unknown
- 2012-11-13 ES ES16154717T patent/ES2698521T5/es active Active
- 2012-11-13 EP EP16154717.9A patent/EP3056187B2/en active Active
-
2015
- 2015-02-05 HK HK15101283.7A patent/HK1200692A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3056187T (pt) | 2018-11-28 |
| ES2698521T3 (es) | 2019-02-05 |
| PL3056187T5 (pl) | 2023-12-04 |
| EP3056187B2 (en) | 2023-08-30 |
| CN107049929B (zh) | 2020-08-04 |
| ES2621009T3 (es) | 2017-06-30 |
| RU2018140275A3 (ru) | 2022-03-23 |
| PL3056187T3 (pl) | 2019-02-28 |
| ITMI20112066A1 (it) | 2013-05-15 |
| FI3056187T4 (fi) | 2023-09-22 |
| DK3056187T3 (en) | 2018-12-10 |
| RU2014119151A (ru) | 2015-12-27 |
| DK2790638T3 (en) | 2017-04-03 |
| PT2790638T (pt) | 2017-04-19 |
| CA2853880A1 (en) | 2013-05-23 |
| EP2790638B1 (en) | 2017-01-04 |
| PL2790638T3 (pl) | 2017-07-31 |
| HK1200692A1 (en) | 2015-08-14 |
| WO2013072304A1 (en) | 2013-05-23 |
| CN107049929A (zh) | 2017-08-18 |
| EP3056187A9 (en) | 2016-11-23 |
| ES2698521T5 (es) | 2024-01-22 |
| CN103987358B (zh) | 2017-04-26 |
| EP3056187B1 (en) | 2018-08-22 |
| US20140179785A1 (en) | 2014-06-26 |
| CA2853880C (en) | 2019-12-10 |
| DK3056187T4 (da) | 2023-09-25 |
| HUE033305T2 (en) | 2017-11-28 |
| RU2688430C2 (ru) | 2019-05-21 |
| EP3056187A1 (en) | 2016-08-17 |
| EP2790638A1 (en) | 2014-10-22 |
| CN103987358A (zh) | 2014-08-13 |
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