RU2018121529A - МОДУЛИРОВАНИЕ ЭКСПРЕССИИ АПОЛИПОПРОТЕИНА C-III (AроCIII) У ЛЮДЕЙ С ДЕФИЦИТОМ ЛИПОПРОТЕИНЛИПАЗЫ (LPLD) - Google Patents

МОДУЛИРОВАНИЕ ЭКСПРЕССИИ АПОЛИПОПРОТЕИНА C-III (AроCIII) У ЛЮДЕЙ С ДЕФИЦИТОМ ЛИПОПРОТЕИНЛИПАЗЫ (LPLD) Download PDF

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RU2018121529A
RU2018121529A RU2018121529A RU2018121529A RU2018121529A RU 2018121529 A RU2018121529 A RU 2018121529A RU 2018121529 A RU2018121529 A RU 2018121529A RU 2018121529 A RU2018121529 A RU 2018121529A RU 2018121529 A RU2018121529 A RU 2018121529A
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apociii
compound
use according
stranded
interfering rna
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RU2018121529A
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Russian (ru)
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Вероника Дж. АЛЕКСАНДЕР
Николас Дж. ВИНЕЙ
Джозеф Л. УИТЗТУМ
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Ионис Фармасьютикалз, Инк.
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Application filed by Ионис Фармасьютикалз, Инк. filed Critical Ионис Фармасьютикалз, Инк.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2018121529A 2013-02-14 2014-02-14 МОДУЛИРОВАНИЕ ЭКСПРЕССИИ АПОЛИПОПРОТЕИНА C-III (AроCIII) У ЛЮДЕЙ С ДЕФИЦИТОМ ЛИПОПРОТЕИНЛИПАЗЫ (LPLD) RU2018121529A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361764969P 2013-02-14 2013-02-14
US61/764,969 2013-02-14
US201361880779P 2013-09-20 2013-09-20
US61/880,779 2013-09-20

Related Parent Applications (1)

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RU2015139055A Division RU2661781C2 (ru) 2013-02-14 2014-02-14 Модулирование экспрессии аполипопротеина с-iii (аросiii) у людей с дефицитом липопротеинлипазы (lpld)

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RU2018121529A true RU2018121529A (ru) 2019-03-06

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RU2018121529A RU2018121529A (ru) 2013-02-14 2014-02-14 МОДУЛИРОВАНИЕ ЭКСПРЕССИИ АПОЛИПОПРОТЕИНА C-III (AроCIII) У ЛЮДЕЙ С ДЕФИЦИТОМ ЛИПОПРОТЕИНЛИПАЗЫ (LPLD)
RU2015139055A RU2661781C2 (ru) 2013-02-14 2014-02-14 Модулирование экспрессии аполипопротеина с-iii (аросiii) у людей с дефицитом липопротеинлипазы (lpld)

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US (4) US9593333B2 (cg-RX-API-DMAC7.html)
EP (2) EP2956176B1 (cg-RX-API-DMAC7.html)
JP (3) JP6313789B2 (cg-RX-API-DMAC7.html)
KR (2) KR20200123263A (cg-RX-API-DMAC7.html)
CN (2) CN108743943A (cg-RX-API-DMAC7.html)
AU (3) AU2014216137B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015019515A8 (cg-RX-API-DMAC7.html)
CA (2) CA3170716A1 (cg-RX-API-DMAC7.html)
DK (1) DK2956176T3 (cg-RX-API-DMAC7.html)
ES (2) ES2680599T3 (cg-RX-API-DMAC7.html)
IL (2) IL240338B (cg-RX-API-DMAC7.html)
MX (2) MX368155B (cg-RX-API-DMAC7.html)
NZ (1) NZ631119A (cg-RX-API-DMAC7.html)
RU (2) RU2018121529A (cg-RX-API-DMAC7.html)
WO (1) WO2014127268A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201505628B (cg-RX-API-DMAC7.html)

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RU2018121529A (ru) * 2013-02-14 2019-03-06 Ионис Фармасьютикалз, Инк. МОДУЛИРОВАНИЕ ЭКСПРЕССИИ АПОЛИПОПРОТЕИНА C-III (AроCIII) У ЛЮДЕЙ С ДЕФИЦИТОМ ЛИПОПРОТЕИНЛИПАЗЫ (LPLD)
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JP2019525772A (ja) 2016-07-08 2019-09-12 スターテン・バイオテクノロジー・ベー・フェー 抗ａｐｏｃ３抗体およびその使用方法
JP2019535839A (ja) 2016-11-29 2019-12-12 ピュアテック ヘルス エルエルシー 治療剤の送達のためのエクソソーム
MA50958A (fr) 2017-04-21 2020-10-14 Staten Biotechnology B V Anticorps anti-apoc3 et leurs méthodes d'utilisation
CN120884604A (zh) 2017-06-02 2025-11-04 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
TWI844541B (zh) 2018-05-11 2024-06-11 新加坡商波濤生命科學有限公司 寡核苷酸組成物及其使用方法
WO2022072244A1 (en) * 2020-10-02 2022-04-07 Ionis Pharmaceuticals, Inc. Methods for reducing apociii expression
CN116814621B (zh) * 2022-08-05 2025-09-09 厦门甘宝利生物医药有限公司 一种抑制apoc3基因表达的rna抑制剂及其应用
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