RU2017138468A - Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения - Google Patents
Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения Download PDFInfo
- Publication number
- RU2017138468A RU2017138468A RU2017138468A RU2017138468A RU2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A
- Authority
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- Russia
- Prior art keywords
- antibody
- cancer
- seq
- sequence
- immunoconjugate
- Prior art date
Links
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 title claims 4
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 title claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 108050003475 Neuregulin Proteins 0.000 claims 6
- 102000014413 Neuregulin Human genes 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 108010017305 cimaglermin Proteins 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 2
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 2
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004907 gland Anatomy 0.000 claims 2
- 150000004676 glycans Chemical group 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000010667 Carcinoma of liver and intrahepatic biliary tract Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010073069 Hepatic cancer Diseases 0.000 claims 1
- 101001010819 Homo sapiens Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 230000003281 allosteric effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000003914 endometrial carcinoma Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 102000057750 human ERBB3 Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000002250 liver carcinoma Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 230000036963 noncompetitive effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000003804 salivary gland carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15305695.7A EP3091033A1 (en) | 2015-05-06 | 2015-05-06 | Anti-human-her3 antibodies and uses thereof |
| EP15305695.7 | 2015-05-06 | ||
| PCT/EP2016/059739 WO2016177664A1 (en) | 2015-05-06 | 2016-05-02 | Anti-human-her3 antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017138468A true RU2017138468A (ru) | 2019-06-06 |
| RU2017138468A3 RU2017138468A3 (enExample) | 2019-09-03 |
Family
ID=53059029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017138468A RU2017138468A (ru) | 2015-05-06 | 2016-05-02 | Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11001634B2 (enExample) |
| EP (2) | EP3091033A1 (enExample) |
| JP (1) | JP6987742B2 (enExample) |
| CN (1) | CN107771183A (enExample) |
| BR (1) | BR112017023874A2 (enExample) |
| CA (1) | CA2985143C (enExample) |
| ES (1) | ES2905531T3 (enExample) |
| PL (1) | PL3292154T3 (enExample) |
| PT (1) | PT3292154T (enExample) |
| RS (1) | RS62912B1 (enExample) |
| RU (1) | RU2017138468A (enExample) |
| WO (1) | WO2016177664A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| CN110724194B (zh) * | 2018-07-17 | 2021-03-19 | 上海生物制品研究所有限责任公司 | 抗her3人源化单克隆抗体及其制剂 |
| US12336995B2 (en) | 2018-09-10 | 2025-06-24 | Mirati Therapeutics, Inc. | Combination therapies |
| GB201913079D0 (en) * | 2019-09-11 | 2019-10-23 | Hummingbird Bioscience Holdings Pte Ltd | Treatment and prevention of cancer using her3 antigen-binding molecules |
| CN113135995B (zh) * | 2020-01-17 | 2022-08-12 | 上海生物制品研究所有限责任公司 | 抗her3单克隆抗体及其应用 |
| US12178880B2 (en) | 2020-12-04 | 2024-12-31 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof |
| EP4355787A4 (en) * | 2021-06-15 | 2025-04-30 | Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. | Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof |
| KR20240137076A (ko) * | 2022-01-25 | 2024-09-19 | 메디링크 테라퓨틱스 (쑤저우) 컴퍼니, 리미티드 | Her3에 대한 항체, 접합체 및 이의 용도 |
| CN115724979B (zh) * | 2022-10-13 | 2025-09-30 | 深圳市百士通科技开发有限公司 | 一种多功能重组抗体及其制备方法和应用 |
| CN116444672B (zh) * | 2023-06-13 | 2023-11-03 | 上海偌妥生物科技有限公司 | 人表皮生长因子3的抗体、其制备方法及其应用 |
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| FI102355B1 (fi) | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
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| AR094403A1 (es) * | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| BR112015031572A2 (pt) * | 2013-06-21 | 2017-07-25 | Dsm Ip Assets Bv | novo processo para a manutenção de uma razão de isômeros de compostos carotenoides |
| BR112016010336A2 (pt) * | 2013-11-07 | 2017-10-03 | Inst Nat Sante Rech Med | Anticorpo anti-humano-her3 alostérico não competitivo com neuregulina, fragmento de anticorpo, sequência de ácido nucleico, vetor, célula hospedeira, composição farmacêutica e método para tratamento de câncer |
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2015
- 2015-05-06 EP EP15305695.7A patent/EP3091033A1/en not_active Withdrawn
-
2016
- 2016-05-02 WO PCT/EP2016/059739 patent/WO2016177664A1/en not_active Ceased
- 2016-05-02 RU RU2017138468A patent/RU2017138468A/ru not_active Application Discontinuation
- 2016-05-02 BR BR112017023874A patent/BR112017023874A2/pt not_active Application Discontinuation
- 2016-05-02 US US15/571,720 patent/US11001634B2/en active Active
- 2016-05-02 CN CN201680035940.1A patent/CN107771183A/zh active Pending
- 2016-05-02 EP EP16722107.6A patent/EP3292154B1/en active Active
- 2016-05-02 PL PL16722107T patent/PL3292154T3/pl unknown
- 2016-05-02 JP JP2018509977A patent/JP6987742B2/ja not_active Expired - Fee Related
- 2016-05-02 RS RS20220065A patent/RS62912B1/sr unknown
- 2016-05-02 PT PT167221076T patent/PT3292154T/pt unknown
- 2016-05-02 ES ES16722107T patent/ES2905531T3/es active Active
- 2016-05-02 CA CA2985143A patent/CA2985143C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107771183A (zh) | 2018-03-06 |
| ES2905531T3 (es) | 2022-04-11 |
| EP3091033A1 (en) | 2016-11-09 |
| CA2985143A1 (en) | 2016-11-10 |
| EP3292154B1 (en) | 2021-11-03 |
| JP6987742B2 (ja) | 2022-01-05 |
| US11001634B2 (en) | 2021-05-11 |
| RS62912B1 (sr) | 2022-03-31 |
| JP2018515137A (ja) | 2018-06-14 |
| PL3292154T3 (pl) | 2022-04-19 |
| EP3292154A1 (en) | 2018-03-14 |
| PT3292154T (pt) | 2022-01-26 |
| BR112017023874A2 (pt) | 2018-07-24 |
| US20180155433A1 (en) | 2018-06-07 |
| CA2985143C (en) | 2023-10-17 |
| WO2016177664A1 (en) | 2016-11-10 |
| RU2017138468A3 (enExample) | 2019-09-03 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20210220 |